5-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propoxy)benzo[d]thiazole
![5-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propoxy)benzo[d]thiazole Structure](CAS/20180703/GIF/1354030-52-6.gif)
- CAS No.
- 1354030-52-6
- Chemical Name:
- 5-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propoxy)benzo[d]thiazole
- Synonyms
- UNC9995;UNC-9995;UNC 9995;5-(3-(4-(2,3-Dichlorophenyl)piperazin-1-yl)propoxy)benzo[d]t...;Benzothiazole, 5-[3-[4-(2,3-dichlorophenyl)-1-piperazinyl]propoxy]-;5-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propoxy)benzo[d]thiazole
- CBNumber:
- CB52995866
- Molecular Formula:
- C20H21Cl2N3OS
- Molecular Weight:
- 422.37
- MDL Number:
- MOL File:
- 1354030-52-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
5-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propoxy)benzo[d]thiazole price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0079640 | UNC9995 99.93% | 1354030-52-6 | 5mg | $379 | 2026-06-04 | Buy |
| ChemScene | CS-0079640 | UNC9995 99.93% | 1354030-52-6 | 10mg | $650 | 2026-06-04 | Buy |
| aablocks | AA024BY8 | UNC9995 >98% | 1354030-52-6 | 5mg | $424 | 2026-06-01 | Buy |
| aablocks | AA024BY8 | UNC9995 >98% | 1354030-52-6 | 10mg | $702 | 2026-06-01 | Buy |
5-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propoxy)benzo[d]thiazole Chemical Properties, Uses, Production
Description
UNC9995 is a β-Arrestin-Biased Dopamine D2 Receptor agonist (β-Arrestin, EC50 = 120 nM; Emax = 88%).
Uses
UNC9995 is a β-arrestin2-biased agonist of dopamine receptor Drd2. UNC9995 inhibits NLRP3 inflammasome activation by enhancing β-arrestin2-NLRP3 interaction, thus prevents neuronal degeneration. Futhermore, UNC9995 activates the Drd2/β-arrestin2 signaling to prevent inflammation-related genes transcription-induced by JAK/STAT3. UNC9995 improves depressive behavior in mouse model, and improves astrocytes dysfunctions[1].
in vivo
UNC9995 (2 mg/kg/day, i.p, 2 weeks) ameliorates depressive-like behavioral phenotype and improves the loss of astrocytes in the hippocampus in both Chronic social defeated stress (CSDS) model and Chronic unpredictable mild stress (CUMS) model in mouse[1].
| Animal Model: | Chronic unpredictable mild stress (CUMS) mouse model[1] |
| Dosage: | 2 mg/kg/d |
| Administration: | IP; 2 weeks |
| Result: | Improved depressive-like symptoms of CUMS mouse model in WT mice but not Arrb2/ mice. |
IC 50
D2 Receptor
References
[1] Liu Y, et al. β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression. J Neuroinflammation. 2022 Oct 1;19(1):240. DOI:10.1186/s12974-022-02597-6
5-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propoxy)benzo[d]thiazole Preparation Products And Raw materials
Raw materials
Preparation Products
5-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propoxy)benzo[d]thiazole Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +86-18949823763 | sales@tnjchem.com | China | 25333 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| Supplier | Advantage |
|---|---|
| Hefei TNJ Chemical Industry Co.,Ltd. | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
