Propargyl-PEG4-Tos
- CAS No.
- 875770-32-4
- Chemical Name:
- Propargyl-PEG4-Tos
- Synonyms
- Propargyl-PEG5-Tos;Propargyl-PEG4-Tos;Propargyl-PEG5-Tos - [P8651];3,6,9,12-tetraoxapentadec-14-yn-1-yl 4-methylbenzene-1-sulfonate;3,6,9,12-Tetraoxapentadec-14-yn-1-ol, 1-(4-methylbenzenesulfonate);2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
- CBNumber:
- CB53062628
- Molecular Formula:
- C18H26O7S
- Molecular Weight:
- 386.46
- MDL Number:
- MFCD28950765
- MOL File:
- 875770-32-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
Propargyl-PEG4-Tos price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | AKB77032 | Propargyl-PEG5-Tos | 875770-32-4 | 0.5g | $900 | 2026-06-04 | Buy |
| Biosynth | AKB77032 | Propargyl-PEG5-Tos | 875770-32-4 | 5g | $900 | 2026-06-04 | Buy |
| Biosynth | AKB77032 | Propargyl-PEG5-Tos | 875770-32-4 | 2g | $900 | 2026-06-04 | Buy |
| Biosynth | AKB77032 | Propargyl-PEG5-Tos | 875770-32-4 | 1g | $900 | 2026-06-04 | Buy |
| Biosynth | AKB77032 | Propargyl-PEG5-Tos | 875770-32-4 | 10g | $1031.3 | 2026-06-04 | Buy |
Propargyl-PEG4-Tos Chemical Properties, Uses, Production
Description
Propargyl-PEG5-Tos is a PEG linker containing a tosyl group and a propargyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.
Biological Activity
Propargyl-PEG4-Tos is a PROTAC linker belonging to the PEG class and can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| PEGs
| Cleavable
|
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Borenpharm Co., Ltd | 027-65563561 | sales@borenpharm.com | China | 1245 | 55 |
| Jinan elephant international trading co., LTD | 13006575422@163.com | China | 6347 | 58 | |
| Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 | 1924344760@qq.com | China | 4229 | 58 |
| Shanghai Moss Medicine Technology Co., Ltd. | +86-188369842 +86-15618151133 | 188369842@qq.com | China | 1965 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3147 | 58 |
| Wuhan Borenpharm Co., Ltd | 027-65563561 18717150066 | 3207347307@qq.com | CHINA | 1238 | 58 |
| Shaanxi Xinyan Bomei Biotechnology Co., Ltd. | 13892832556 | 2440688701@qq.com | China | 1981 | 58 |
| Shanghai Jiange Chemical Co., Ltd. | 15921040873 | 1434142450@qq.com | CHINA | 7643 | 58 |
View Latest Price from Propargyl-PEG4-Tos manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-13 | Propargyl-PEG4-Tos
875770-32-4
|
10g | TargetMol Chemicals Inc. | ||||
 |
2025-06-07 | Propargyl-PEG5-Tos
875770-32-4
|
5g | >95.00% | 5g | Xian confluore Biological Technology Co., Ltd. |
-
- Propargyl-PEG4-Tos
875770-32-4
- $0.00
- TargetMol Chemicals Inc.
-
- Propargyl-PEG5-Tos
875770-32-4
- $0.00
- >95.00%
- Xian confluore Biological Technology Co., Ltd.
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