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6-Chloropyridine-3-sulfonamide

CAS No.
40741-46-6
Chemical Name:
6-Chloropyridine-3-sulfonamide
Synonyms
6-Chloro-3-pyridinesulfonaMide;6-CHLOROPYRIDINE-3-SULFONAMIDE;3-Pyridinesulfonamide, 6-chloro-;6-Chloro-pyridine-3-sulfonic acid aMide;3-Pyridinesulfonamide,6-chloro-(7CI,9CI);6-Chloropyridine-3-sulfonamide ISO 9001:2015 REACH
CBNumber:
CB5313985
Molecular Formula:
C5H5ClN2O2S
Molecular Weight:
192.62
MDL Number:
MFCD00661410
MOL File:
40741-46-6.mol
Last updated:2025-08-08 17:45:00

6-Chloropyridine-3-sulfonamide Properties

Melting point 158-159 °C(Solv: water (7732-18-5))
Boiling point 383.2±52.0 °C(Predicted)
Density 1.558±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 9.24±0.60(Predicted)

SAFETY

Risk and Safety Statements

Signal word  Warning
Hazard statements  H313-H303
Precautionary statements  P312-P312

6-Chloropyridine-3-sulfonamide price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 162127 6-Chloro-3-pyridinesulfonamide 40741-46-6 100mg $531 2026-06-03 Buy
Matrix Scientific 144279 6-Chloropyridine-3-sulfonamide 40741-46-6 1.00g $478 2026-05-18 Buy
Matrix Scientific 144279 6-Chloropyridine-3-sulfonamide 40741-46-6 5.00g $1432 2026-05-18 Buy
Synthonix C40905 6-Chloropyridine-3-sulfonamide 95+% 40741-46-6 100mg $42 2026-05-06 Buy
Synthonix C40905 6-Chloropyridine-3-sulfonamide 95+% 40741-46-6 250mg $48 2026-05-06 Buy
Product number Packaging Price Buy
162127 100mg $531 Buy
144279 1.00g $478 Buy
144279 5.00g $1432 Buy
C40905 100mg $42 Buy
C40905 250mg $48 Buy

6-Chloropyridine-3-sulfonamide Chemical Properties, Uses, Production

Uses

6-Chloro-3-pyridinesulfonamide, is a heterocylic building block used for chemical synthesis. It can also be used for the synthesis of diuretics and carbonic anhydrase inhibitors.

Synthesis

2-Chloropyridine-5-sulfonyl chloride

6684-39-5

6-Chloropyridine-3-sulfonamide

40741-46-6

The general procedure for the synthesis of 6-chloro-3-sulfapyridine from 2-chloropyridine-5-sulfonyl chloride was as follows: 6-chloropyridine-3-sulfonyl chloride (5.0 g, 0.024 mol) was dissolved in a 0.5 M ammonia dioxane solution (125 mL) at -50 °C. The reaction mixture was slowly warmed to room temperature and stirred continuously for 1 hour. After completion of the reaction, the mixture was filtered through diatomaceous earth and the filter cake was washed twice with dioxane. The filtrate was concentrated in vacuum to afford 6-chloropyridine-3-sulfonic acid amide as an off-white solid in a yield of 4.55 g (98% yield). The product was analyzed by liquid chromatography (LC) under the detection condition of UV215 nm; retention time (Rt) 1.05 min and 100% purity. Mass spectrometry (m/z) analytical result (ES+): 193/195. NMR hydrogen spectroscopy (400 MHz; d6-DMSO) data: δ 8.79 (1H, d), 8.21 (1H, dd), 7.75 (1H, d), 7.70 (2H, br s).

References

[1] Patent: WO2008/49605, 2008, A1. Location in patent: Page/Page column 15-16
[2] Patent: WO2008/138594, 2008, A1. Location in patent: Page/Page column 16
[3] Patent: WO2008/21389, 2008, A2. Location in patent: Page/Page column 253
[4] Patent: WO2007/44729, 2007, A2. Location in patent: Page/Page column 186
[5] Patent: WO2008/127594, 2008, A2. Location in patent: Page/Page column 376

6-Chloropyridine-3-sulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

Global Suppliers ( 96)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shanghai Sphchem Co., Ltd. 021-56491756 13512199871 2819742715@qq.com China 3994 55
Shanghai yirong biology science and technology co., ltd 18049974220 3060526242@qq.com China 999 60
Acorn PharmaTech Co., Ltd. 025-58395930 sales@acornpharma.com China 982 60
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9510 58

View Latest Price from 6-Chloropyridine-3-sulfonamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-Chloropyridine-3-sulfonamide  pictures 2026-08-20 6-Chloropyridine-3-sulfonamide
40741-46-6
$1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
6-Chloropyridine-3-sulfonamide pictures 2019-07-12 6-Chloropyridine-3-sulfonamide
40741-46-6
$1.00 1KG 99% 1ton Career Henan Chemical Co

6-Chloropyridine-3-sulfonamide Spectrum

6-CHLOROPYRIDINE-3-SULFONAMIDE 3-Pyridinesulfonamide,6-chloro-(7CI,9CI) 6-Chloro-pyridine-3-sulfonic acid aMide 6-Chloro-3-pyridinesulfonaMide 3-Pyridinesulfonamide, 6-chloro- 6-Chloropyridine-3-sulfonamide ISO 9001:2015 REACH 40741-46-6 Pyridines SULFONAMIDE