2-Chloropyridine-5-sulfonyl chloride
- CAS No.
- 6684-39-5
- Chemical Name:
- 2-Chloropyridine-5-sulfonyl chloride
- Synonyms
- AURORA 16313;AKOS BBS-00006680;OTAVA-BB BB7110951371;2-Chloropyridine-5-sulfonyl;2-chloro-5-pyridinesulfonylchloride;6-Chloro-3-pyridinesulfonyl Chloride;2-Chloropyridine-5-sulphonylchloride;2-CHLOROPYRIDINE-5-SULFONYL CHLORIDE;2-chloro-5-pyridinesulphonyl chloride;3-Pyridinesulfonylchloride, 6-chloro-
- CBNumber:
- CB1416705
- Molecular Formula:
- C5H3Cl2NO2S
- Molecular Weight:
- 212.05
- MDL Number:
- MFCD03541049
- MOL File:
- 6684-39-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 51 °C |
|---|---|
| Boiling point | 132 °C(Press: 8 Torr) |
| Density | 1.615±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | solid |
| pka | -5.29±0.10(Predicted) |
| Appearance | White to light yellow Solid |
| InChI | InChI=1S/C5H3Cl2NO2S/c6-5-2-1-4(3-8-5)11(7,9)10/h1-3H |
| InChIKey | QXZKKHONVQGXAK-UHFFFAOYSA-N |
| SMILES | C1=NC(Cl)=CC=C1S(Cl)(=O)=O |
| CAS DataBase Reference | 6684-39-5(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314-H302+H312+H332 |
| Precautionary statements | P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501 |
| Hazard Codes | Xi |
| Risk Statements | 36 |
| Safety Statements | 26 |
| RIDADR | UN3261 |
| WGK Germany | WGK 3 |
| HazardClass | 8 |
| HS Code | 2933399990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 |
| Limited Quantities | 5.0 kg (11 lbs) (solid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) |
2-Chloropyridine-5-sulfonyl chloride price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS010949 | 6-chloro-pyridine-3-sulfonyl chloride AldrichCPR | 100 mg | $197 | 2026-04-30 | Buy | |
| Usbiological | 234671 | 6-Chloropyridine-3-sulfonyl chloride | 250mg | $186 | 2026-06-03 | Buy | |
| Usbiological | 234671 | 6-Chloropyridine-3-sulfonyl chloride | 1g | $222 | 2026-06-03 | Buy | |
| Usbiological | 234671 | 6-Chloropyridine-3-sulfonyl chloride | 5g | $506 | 2026-06-03 | Buy | |
| Usbiological | 234671 | 6-Chloropyridine-3-sulfonyl chloride | 25g | $1493 | 2026-06-03 | Buy |
2-Chloropyridine-5-sulfonyl chloride Chemical Properties, Uses, Production
Uses
6-Chloro-3-pyridinesulfonyl Chloride, is a heterocylic building block used for chemical synthesis. It is also an intermediate in the synthesis of 6-Aminopyridine-3-sulfonamide (A628835), that can be used as anticoccidial agents.
Synthesis
5350-93-6
6684-39-5
General procedure for the synthesis of 2-chloropyridine-5-sulfonyl chloride from 2-chloro-5-aminopyridine: 10 g (79.2 mmol) of 2-chloro-5-aminopyridine was dissolved in a mixture of concentrated hydrochloric acid (16 mL) and glacial acetic acid (89 mL), and cooled to 10 °C in an ice bath. 5.46 g (79.2 mmol) of sodium nitrite was added in batches and the reaction temperature was controlled to be below 15 °C. After stirring the reaction mixture for 1 hour, it was slowly added dropwise to a solution containing sulfur dioxide (carrier 27 mL), 2.77 g (16.2 mmol) of sulfur dioxide, copper(II) chloride dihydrate, and a solution consisting of acetic acid (59 mL) and water (11 mL), with the dropwise addition time being controlled to be between 5 and 10 minutes. The reaction mixture was gradually warmed to room temperature and subsequently poured into an ice-water mixture (300 mL) and stirring was continued for 15 minutes. The precipitate was isolated by filtration, washed with water (2 x 100 mL) and dried under reduced pressure to give 12.99 g of 2-chloropyridine-5-sulfonyl chloride. The product was characterized by 1H NMR (400 MHz, chloroform-d): δ 7.62 (1H, d, J = 8.31 Hz), 8.26 (1H, dd, J = 8.56,2.69 Hz), 9.04 (1H, d, J = 2.69 Hz).
References
[1] Patent: US2008/39464, 2008, A1. Location in patent: Page/Page column 30-31
[2] Organic Process Research and Development, 2009, vol. 13, # 5, p. 875 - 879
[3] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 13, p. 3947 - 3953
[4] Patent: WO2009/39328, 2009, A1. Location in patent: Page/Page column 54
[5] Patent: EP1144368, 2004, B1. Location in patent: Page 64
2-Chloropyridine-5-sulfonyl chloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from 2-Chloropyridine-5-sulfonyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 2-Chloropyridine-5-sulfonyl chloride
6684-39-5
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2019-07-06 | 2-Chloropyridine-5-sulfonyl chloride
6684-39-5
|
$1.00 | 1kg | 95%-99% | Career Henan Chemical Co |
-
- 2-Chloropyridine-5-sulfonyl chloride
6684-39-5
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Chloropyridine-5-sulfonyl chloride
6684-39-5
- $1.00
- 95%-99%
- Career Henan Chemical Co
