Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>IDH-305

IDH-305

IDH-305 Structure
IDH-305 structure
CAS No.
1628805-46-8
Chemical Name:
IDH-305
Synonyms
IDH305;IDH-305;IDH-305 ，S3574;IDH305 (IDH-305;IDH-305, 10 mM in DMSO;IDH-305;IDH 305;IDH305;Isocitrate Dehydrogenase (IDH),IDH-305,Inhibitor,IDH305,inhibit,IDH 305;(R)-4-((S)-1-Fluoroethyl)-3-(2-(((S)-1-(4-methyl-2'-(trifluoromethyl)-[3,4'-bipyridin]-6-yl)ethyl)amino)pyrimidin-4-yl)oxazolidin-2-one;(4R)-4-[(1S)-1-Fluoroethyl]-3-[2-[[(1S)-1-[4-methyl-2'-(trifluoromethyl)[3,4'-bipyridin]-6-yl]ethyl]amino]-4-pyrimidinyl]-2-oxazolidinone;2-Oxazolidinone, 4-[(1S)-1-fluoroethyl]-3-[2-[[(1S)-1-[4-methyl-2'-(trifluoromethyl)[3,4'-bipyridin]-6-yl]ethyl]amino]-4-pyrimidinyl]-, (4R)-
CBNumber:
CB53158525
Molecular Formula:
C23H22F4N6O2
Molecular Weight:
490.45
MDL Number:
MFCD31630851
MOL File:
1628805-46-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-14 16:49:18
Request For Quotation

IDH-305 Properties

Boiling point 597.6±60.0 °C(Predicted)
Density 1.370±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH7.2)(1:20): 0.05 mg/ml
form A crystalline solid
pka 4.07±0.10(Predicted)
color White to off-white
FDA UNII A791KH7YZW

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

IDH-305 price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 24107 IDH305 ≥98% 1628805-46-8 1mg $95 2026-04-30 Buy
Cayman Chemical 24107 IDH305 ≥98% 1628805-46-8 5mg $439 2026-04-30 Buy
Cayman Chemical 24107 IDH305 ≥98% 1628805-46-8 10mg $785 2026-04-30 Buy
Biosynth DQC80546 IDH 305 1628805-46-8 1mg $250 2026-06-04 Buy
Biosynth DQC80546 IDH 305 1628805-46-8 5mg $609 2026-06-04 Buy
Product number Packaging Price Buy
24107 1mg $95 Buy
24107 5mg $439 Buy
24107 10mg $785 Buy
DQC80546 1mg $250 Buy
DQC80546 5mg $609 Buy

IDH-305 Chemical Properties, Uses, Production

Uses

(4R)-4-[(1S)-1-Fluoroethyl]-3-[2-[[(1S)-1-[4-methyl-2''-(trifluoromethyl)[3,4''-bipyridin]-6-yl]ethyl]amino]-4-pyrimidinyl]-2-oxazolidinone, is an inhibitor of isocitrate dehydrogenase (IDH) which is an essential enzyme for cellular respiration in the tricarboxylic acid (TCA) cycle.

in vivo

IDH-305 (30-300 mg/kg; p.o.; twice daily for 21 days) inhibits 2-HG production and 2-HG-dependent tumor growth of an IDH1 mutant PDX melanoma model[1].

Animal Model:nu/nu mice (HMEX2838-IDH1R132C+/-PDX model)[1]
Dosage:30, 100, 300 mg/kg
Administration:Oral gavage; twice daily for 21 days
Result:Resulted in 62-67% 2-HG reduction and significant anti-tumor activity at 100 mg/kg and 97-99% 2-HG reduction and partial tumor regression of 32% at 300 mg/kg.

IC 50

IDH1

IDH-305 Preparation Products And Raw materials

Raw materials

Preparation Products

IDH-305 Suppliers

Global Suppliers ( 48)
Supplier Tel Email Country ProdList Advantage
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Shanghai XingMo Biotechnology Co., Ltd. +86 13524779951; 13524779951 2075692521@qq.com China 294 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Kaixin Chemical (Hong Kong) Limited 010-88886666-01 13112345678 loyson@qq.com China 589 55
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6288 58
DC Chemicals 021-58447131 13564518121 doncunbiosci@gmail.com China 618 58
Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd 0371-88900765 18037465274 3430974218@qq.com China 14171 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Supplier Advantage
BOC Sciences 65
Shanghai XingMo Biotechnology Co., Ltd. 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
ShangHai Biochempartner Co.,Ltd 62
Kaixin Chemical (Hong Kong) Limited 55
TargetMol Chemicals Inc. 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 58
DC Chemicals 58
Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58

View Latest Price from IDH-305 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
IDH-305 pictures 2026-07-13 IDH-305
1628805-46-8
 $31.00-107.00 99.68% 10g TargetMol Chemicals Inc.
  • IDH-305 pictures
  • IDH-305
    1628805-46-8
  • $31.00-107.00
  • 99.68%
  • TargetMol Chemicals Inc.

IDH-305 Spectrum

IDH-305(1628805-46-8)1HNMR

1628805-46-8 (IDH-305) Related Search:

IDH-305 NHI 2 GSK2837808A C75 6-Aminopyridine-3-carboxamide
DS-1001b Chemical Structure

1of2

IDH-305 (4R)-4-[(1S)-1-fluoroethyl]-3-(2-{[(1S)-1-[4-methyl-2'-(trifluoromethyl)-[3,4'-bipyridin]-6-yl]ethyl]amino}pyrimidin-4-yl)-1,3-oxazolidin-2-one IDH-305;IDH 305;IDH305 2-Oxazolidinone, 4-[(1S)-1-fluoroethyl]-3-[2-[[(1S)-1-[4-methyl-2'-(trifluoromethyl)[3,4'-bipyridin]-6-yl]ethyl]amino]-4-pyrimidinyl]-, (4R)- (4R)-4-[(1S)-1-Fluoroethyl]-3-[2-[[(1S)-1-[4-methyl-2'-(trifluoromethyl)[3,4'-bipyridin]-6-yl]ethyl]amino]-4-pyrimidinyl]-2-oxazolidinone Isocitrate Dehydrogenase (IDH),IDH-305,Inhibitor,IDH305,inhibit,IDH 305 (R)-4-((S)-1-Fluoroethyl)-3-(2-(((S)-1-(4-methyl-2'-(trifluoromethyl)-[3,4'-bipyridin]-6-yl)ethyl)amino)pyrimidin-4-yl)oxazolidin-2-one IDH-305, 10 mM in DMSO IDH305 (IDH-305 IDH-305 ，S3574 IDH305 1628805-46-8 C23H22F4N6O2