IDH-305 NEW
| Price | $52 | $128 | $178 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-26 |
Product Details
| Product Name: IDH-305 | CAS No.: 1628805-46-8 |
| Purity: 99.13% | Supply Ability: 10g |
| Release date: 2025/10/26 |
Product Introduction
Bioactivity
| Name | IDH-305 |
| Description | IDH-305 is an orally available, mutation-selective, and brain-penetrant IDH1 inhibitor targeting the IDH1 (R132) mutation. It is 200-fold more selective for mutant IDH1 isoforms than wild type, with IC50s of 27 nM, 28 nM, and 6.14 nM for IDH1R132H, IDH1R132C, and IDH1WT, respectively. |
| In vitro | IDH-305 suppresses HCT116-IDH1R132H /- cells (IC50 of 24 nM)[1]. |
| In vivo | P.o. administration of 30-300 mg/kg IDH-305 twice daily for 21 days suppresses 2-HG production and 2-HG-dependent tumor growth of an IDH1 mutant PDX melanoma model [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 100 mg/mL (203.89 mM), Sonication is recommended. |
| Keywords | Isocitrate Dehydrogenase (IDH) | Inhibitor | inhibit | IDH-305 | IDH305 | IDH1-WT | IDH1WT | IDH1-R132H | IDH1R132H | IDH1-R132C | IDH1R132C | IDH 305 |
| Inhibitors Related | Disulfiram | 1-Methoxy-4-propylbenzene | Methotrexate | Mycophenolate Mofetil | 18β-Glycyrrhetinic acid | Ribavirin | Methotrexate disodium | 2-Methylaminoethanol | Benzyl alcohol | 2-Bromoacetamide | Isomalt | Sodium Oxamate |
| Related Compound Libraries | Bioactive Compound Library | ReFRAME Related Library | Hematonosis Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Metabolism Compound Library | Bioactive Compounds Library Max | Anti-Liver Cancer Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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