IDH-305

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Company Name: BOC Sciences  
Tel: 1-631-485-4226; 16314854226
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Company Name: Shanghai XingMo Biotechnology Co., Ltd.  
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Company Name: ShangHai Biochempartner Co.,Ltd  
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Company Name: Kaixin Chemical (Hong Kong) Limited  
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IDH-305 manufacturers

  • IDH-305
  • IDH-305 pictures
  • $31.00
  • 2026-07-13
  • CAS:1628805-46-8
  • Purity: 99.68%
  • Supply Ability: 10g
IDH-305 Basic information
Product Name:IDH-305
Synonyms:IDH-305;(4R)-4-[(1S)-1-fluoroethyl]-3-(2-{[(1S)-1-[4-methyl-2'-(trifluoromethyl)-[3,4'-bipyridin]-6-yl]ethyl]amino}pyrimidin-4-yl)-1,3-oxazolidin-2-one;IDH-305;IDH 305;IDH305;2-Oxazolidinone, 4-[(1S)-1-fluoroethyl]-3-[2-[[(1S)-1-[4-methyl-2'-(trifluoromethyl)[3,4'-bipyridin]-6-yl]ethyl]amino]-4-pyrimidinyl]-, (4R)-;(4R)-4-[(1S)-1-Fluoroethyl]-3-[2-[[(1S)-1-[4-methyl-2'-(trifluoromethyl)[3,4'-bipyridin]-6-yl]ethyl]amino]-4-pyrimidinyl]-2-oxazolidinone;Isocitrate Dehydrogenase (IDH),IDH-305,Inhibitor,IDH305,inhibit,IDH 305;(R)-4-((S)-1-Fluoroethyl)-3-(2-(((S)-1-(4-methyl-2'-(trifluoromethyl)-[3,4'-bipyridin]-6-yl)ethyl)amino)pyrimidin-4-yl)oxazolidin-2-one;IDH-305, 10 mM in DMSO
CAS:1628805-46-8
MF:C23H22F4N6O2
MW:490.45
EINECS:
Product Categories:
Mol File:1628805-46-8.mol
IDH-305 Structure
IDH-305 Chemical Properties
Boiling point 597.6±60.0 °C(Predicted)
density 1.370±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH7.2)(1:20): 0.05 mg/ml
form A crystalline solid
pka4.07±0.10(Predicted)
color White to off-white
Safety Information
MSDS Information
IDH-305 Usage And Synthesis
Uses(4R)-4-[(1S)-1-Fluoroethyl]-3-[2-[[(1S)-1-[4-methyl-2''-(trifluoromethyl)[3,4''-bipyridin]-6-yl]ethyl]amino]-4-pyrimidinyl]-2-oxazolidinone, is an inhibitor of isocitrate dehydrogenase (IDH) which is an essential enzyme for cellular respiration in the tricarboxylic acid (TCA) cycle.
in vivo

IDH-305 (30-300 mg/kg; p.o.; twice daily for 21 days) inhibits 2-HG production and 2-HG-dependent tumor growth of an IDH1 mutant PDX melanoma model[1].

Animal Model:nu/nu mice (HMEX2838-IDH1R132C+/-PDX model)[1]
Dosage:30, 100, 300 mg/kg
Administration:Oral gavage; twice daily for 21 days
Result:Resulted in 62-67% 2-HG reduction and significant anti-tumor activity at 100 mg/kg and 97-99% 2-HG reduction and partial tumor regression of 32% at 300 mg/kg.
IC 50IDH1
IDH-305 Preparation Products And Raw materials
Tag:IDH-305(1628805-46-8) Related Product Information
IDH-305 NHI 2 GSK2837808A C75 6-Aminopyridine-3-carboxamide DS-1001b Chemical Structure