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tert-Butyl 4-aminobenzoate

tert-Butyl 4-aminobenzoate structure

CAS No.: 18144-47-3

Chemical Name:: tert-Butyl 4-aminobenzoate

Synonyms: BUTTPARK 14\02-67;tert-Butyl 4-aminobe;ert-butyl4-aminobenzoate;Tert-Butyl p-aMinobenzoate;TERT-BUTYL 4-AMINOBENZOATE;tert-butyl 4-azanylbenzoate;4-(tert-Butoxycarbonyl)aniline;tert-Butyl 4-Aminobenzoate >tert-butyl 4-aminobenzoate 98%;1,1-Dimethylethyl 4-aminobenzoate

CBNumber:: CB5329814

Molecular Formula:: C11H15NO2

Molecular Weight:: 193.24

MDL Number:: MFCD00665790

MOL File:: 18144-47-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 04:53:18

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tert-Butyl 4-aminobenzoate Properties

Melting point	108-110 °C
Boiling point	322.4±15.0 °C(Predicted)
Density	1.078±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
form	powder to crystal
pka	2.43±0.10(Predicted)
color	White to Light yellow to Light orange
BRN	2803178
Major Application	peptide synthesis
InChI	InChI=1S/C11H15NO2/c1-11(2,3)14-10(13)8-4-6-9(12)7-5-8/h4-7H,12H2,1-3H3
InChIKey	KYORUZMJUKHKFS-UHFFFAOYSA-N
SMILES	C(OC(C)(C)C)(=O)C1=CC=C(N)C=C1
CAS DataBase Reference	18144-47-3(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

10-34

Hazard Note

Irritant

HS Code

29224999

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
2		1

tert-Butyl 4-aminobenzoate price More Price(70)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	06975	tert-Butyl 4-aminobenzoate ≥98.0% (NT)	18144-47-3	5g	$178	2026-04-30	Buy
Sigma-Aldrich	06975	tert-Butyl 4-aminobenzoate ≥98.0% (NT)	18144-47-3	25g	$412	2026-04-30	Buy
TCI Chemical	B3504	tert-Butyl 4-Aminobenzoate >98.0%(GC)(T)	18144-47-3	5g	$80	2026-04-30	Buy
TCI Chemical	B3504	tert-Butyl 4-Aminobenzoate >98.0%(GC)(T)	18144-47-3	25g	$228	2026-04-30	Buy
Activate Scientific	AS26641	tert-butyl 4-Aminobenzoate 98%	18144-47-3	5g	$20	2026-06-04	Buy

Product number	Packaging	Price	Buy
06975	5g	$178	Buy
06975	25g	$412	Buy
B3504	5g	$80	Buy
B3504	25g	$228	Buy
AS26641	5g	$20	Buy

tert-Butyl 4-aminobenzoate Chemical Properties, Uses, Production

Uses

tert-Butyl 4-aminobenzoate can be used to synthesise structural units for antifolate and a novel liver-targeted coupling of PSN-357, a glycogen phosphorylase inhibitor for the treatment of diabetes. It can also be used in the synthesis of tert-butyl 4-aminobenzoate n-substituted derivatives^[1].

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

tert-Butyl 4-aminobenzoate is synthesised using tert-butyl 4-nitrobenzoate as raw material by chemical reaction. The specific synthesis steps are as follows:
Tert-butyl 4-nitrobenzoate (4.75 g, 21.279 mmol) was dissolved in MeOH (200 ml) and added with CAUTION was Pd/C (475 mg, 0.1 equiv. w/w) and the flask evacuated prior to purging with N2, re-evacuation and purging with H2. The mixture was stirred under H2 for 5 hours until complete. The mixture was filtered through celite and evaporated to a white solid (4.11 g, 21.269 mmol, quant.). Rf 0.29 [20% EtOAc in Hexane]. Mp. I l l - 113 0C. 1H NMR (400 MHz, CDCl3) δ 7.79 (2H, dt, J=8.6, 2.3 Hz, 2ArH), 6.61 (2H, dt, J=8.6, 2.3 Hz, 2ArH), 4.00 (2H, br s, NH2), 1.56 (9H, s, C(CH3)3) ppm. 13C NMR (100 MHz, CDCl3) δ 165.9 (C=O), 150.4 (ArC), 131.3 (ArCH), 121.7 (ArC), 113.7 (ArCH), 80.0 (C(CH3)3), 28.3 (C(CH3)3) ppm. IR (neat) υmax 3415, 3345, 3235, 2972, 1682, 1598, 1367, 1287, 1154, 1115 cm 1. HRMS mJz calc. C11H15NO2 [M+l] 194.1176, found [M+l] 194.1179.
tert-Butyl 4-aminobenzoate synthesis

References

[1] V. BAVETSIAS E. H. Synthesis of N-substituted derivatives of tert-butyl 4-aminobenzoate via a palladium-catalysed reaction[J]. Journal of Chemical Research-s, 2000. DOI:10.3184/030823400103168100.

tert-Butyl 4-aminobenzoate Preparation Products And Raw materials

Raw materials

tert-Butyl-4-bromobenzoate tert-Butyl 4-nitrobenzoate Hydrogen Methanol

Preparation Products

tert-Butyl 4-aminobenzoate Suppliers

Global Suppliers ( 247)

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Evonik Biotechnology Co. LTD	15672878902	hnyingchuang@163.com	China	4046	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Changzhou Sunchem Pharmaceutical Chemical Material Co.,Ltd.	0519-85195575 15861192208;15861192208;13685253038	850305@sunkechem.com	China	72	69
Changzhou Sunlight Pharmaceutical Co., Ltd	519-83131668 15995063688	info@sunlightchem.com	China	100	69
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
future industrial shanghai co., ltd	400-0066400 13621662912	sales@jonln.com	China	1989	65
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	0311-89250318 13582355795	master@sjzsdyn.com	China	2776	65
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66

Supplier	Advantage
Henan Evonik Biotechnology Co. LTD	58
J & K SCIENTIFIC LTD.	76
Changzhou Sunchem Pharmaceutical Chemical Material Co.,Ltd.	69
Changzhou Sunlight Pharmaceutical Co., Ltd	69
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
future industrial shanghai co., ltd	65
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	65
Capot Chemical Co., Ltd	66

View Latest Price from tert-Butyl 4-aminobenzoate manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-18	tert-Butyl 4-aminobenzoate 18144-47-3	1kg	99%	500kgs	WUHAN FORTUNA CHEMICAL CO., LTD
2025-04-04	tert-Butyl 4-aminobenzoate 18144-47-3	1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.
2023-02-18	Tert-Butyl4-aminobenzoate 18144-47-3	1kg	98%		Aromsyn Co., Ltd.

tert-Butyl 4-aminobenzoate
18144-47-3
$0.00
99%
WUHAN FORTUNA CHEMICAL CO., LTD

tert-Butyl 4-aminobenzoate
18144-47-3
98%
Henan Aochuang Chemical Co.,Ltd.

Tert-Butyl4-aminobenzoate
18144-47-3
98%
Aromsyn Co., Ltd.

tert-Butyl 4-aminobenzoate Spectrum

tert-Butyl 4-aminobenzoate(18144-47-3)¹HNMR

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TERT-BUTYL 4-AMINOBENZOATE 4-AMINOBENZOIC ACID TERT-BUTYL ESTER BUTTPARK 14\02-67 tert-butyl 4-azanylbenzoate tert-Butyl 4-aminobe 4-(tert-Butoxycarbonyl)aniline H-4-Abz-OtBu(Tert-butyl 4-AMinobenzoate) Tert-Butyl p-aMinobenzoate Para aMinobenzoic acidtert butyl ester Benzoic acid, 4-aMino-,1,1-diMethylethyl ester tert-Butyl 4-AMinobenzoate, 98.0%(GC&T tert-Butyl 4-aminobenzoate >=98.0% (NT) 4-[[2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl]-oxomethyl]-1-piperazinecarboxylic acid tert-butyl ester tert-Butyl 4-Aminobenzoate > ert-butyl4-aminobenzoate tert-Butyl 4-aminobenzoate USP/EP/BP 1,1-Dimethylethyl 4-aminobenzoate tert-Butyl 4-aminobenzoate tert-butyl 4-aminobenzoate 98% 18144-47-3 18114-47-3 C11H15NO2 Aromatic Amino Acids Specialty Synthesis Peptide Synthesis Unnatural Amino Acid Derivatives API intermediates Aromatic Amino Acids Peptide Synthesis Unnatural Amino Acid Derivatives