ChemicalBook >> CAS DataBase List >>4,4,4-Trifluoro-1-phenyl-1,3-butanedione

4,4,4-Trifluoro-1-phenyl-1,3-butanedione

4,4,4-Trifluoro-1-phenyl-1,3-butanedione structure

CAS No.: 326-06-7

Chemical Name:: 4,4,4-Trifluoro-1-phenyl-1,3-butanedione

Synonyms: 4,4,4-TRIFLUORO-1-PHENYLBUTANE-1,3-DIONE;3-BENZOYL-1,1,1-TRIFLUOROACETONE;BENZOYLTRIFLUOROACETONE;BENZOYL-1,1,1-TRIFLUOROACETONE;NSC 42628;NSC 405720;AKOS MSC-0330;Celecoxib Impurity 35;LABOTEST-BB LT00005189;4-Phenyl-1,1,1-trifluorobuta

CBNumber:: CB5331972

Molecular Formula:: C10H7F3O2

Molecular Weight:: 216.16

MDL Number:: MFCD00000425

MOL File:: 326-06-7.mol

MSDS File:: SDS

Last updated:2026-01-13 11:21:45

Product description	Number	Pack Size	Price
4,4,4-Trifluoro-1-phenyl-1,3-butanedione 99%	217042	25g	$94.5
4,4,4-Trifluoro-1-phenyl-1,3-butanedione >98.0%(GC)	T0437	25g	$114
Benzoyl-1,1,1-trifluoroacetone, 98%	09-1210	10g	$45
Benzoyl-1,1,1-trifluoroacetone, 98%	09-1210	50g	$138
Benzoyl-1,1,1-trifluoroacetone	B209730	250g	$495
More product size

Request For Quotation

4,4,4-Trifluoro-1-phenyl-1,3-butanedione Properties

Melting point	38-40 °C(lit.)
Boiling point	224 °C(lit.)
Density	1,113 g/cm³
Flash point	210 °F
storage temp.	Sealed in dry,Room Temperature
solubility	95% ethanol: soluble25mg/mL, clear, colorless to yellow
pka	pK1: 6.35 (25°C)
form	Crystalline Low Melting Solid
color	White to yellow
Water Solubility	Sparingly Soluble in water (0.24 g/L) (25°C).
BRN	1875083
InChI	InChI=1S/C10H7F3O2/c11-10(12,13)9(15)6-8(14)7-4-2-1-3-5-7/h1-5H,6H2
InChIKey	VVXLFFIFNVKFBD-UHFFFAOYSA-N
SMILES	C(C1=CC=CC=C1)(=O)CC(=O)C(F)(F)F
CAS DataBase Reference	326-06-7(CAS DataBase Reference)
EPA Substance Registry System	1,3-Butanedione, 4,4,4-trifluoro-1-phenyl- (326-06-7)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

24/25

WGK Germany

TSCA

TSCA listed

HazardClass

IRRITANT

HS Code

29147000

Storage Class

11 - Combustible Solids

NFPA 704

	1
2		0

4,4,4-Trifluoro-1-phenyl-1,3-butanedione price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	217042	4,4,4-Trifluoro-1-phenyl-1,3-butanedione 99%	326-06-7	25g	$94.5	2025-07-31	Buy
TCI Chemical	T0437	4,4,4-Trifluoro-1-phenyl-1,3-butanedione >98.0%(GC)	326-06-7	25g	$114	2025-07-31	Buy
Strem Chemicals	09-1210	Benzoyl-1,1,1-trifluoroacetone, 98%	326-06-7	10g	$45	2024-03-01	Buy
Strem Chemicals	09-1210	Benzoyl-1,1,1-trifluoroacetone, 98%	326-06-7	50g	$138	2024-03-01	Buy
TRC	B209730	Benzoyl-1,1,1-trifluoroacetone	326-06-7	250g	$495	2021-12-16	Buy

Product number	Packaging	Price	Buy
217042	25g	$94.5	Buy
T0437	25g	$114	Buy
09-1210	10g	$45	Buy
09-1210	50g	$138	Buy
B209730	250g	$495	Buy

4,4,4-Trifluoro-1-phenyl-1,3-butanedione Chemical Properties,Uses,Production

Chemical Properties

WHITE TO YELLOW CRYSTALLINE LOW MELTING SOLID

Uses

4,4,4-Trifluoro-1-phenyl-1,3-butanedione was used in the synthesis of series of NNO ketoimines bearing trifluoromethyl substituents via Schiff base condensation reaction. It was also used in mixed-ligand chelate extraction of trivalent lanthanides and as a ligand in the preparation of ternary lanthanide (Ln) complexes.

Synthesis

To a three-necked flask fitted with magnetic stirring, a dropping funnel and an inert gas device, 2 mL of anhydrous methanol was added with stirring and 0.230 g (10 ) of clean sodium metal crumbs were added. mmol) of clean sodium metal crumbs, and after all the sodium was dissolved, a water bath was installed to evaporate the unreacted methanol in the reaction system. After the sodium methanol was completely dried, 5 was added mL of anhydrous ether, quickly stirred well, and then cooled in an ice bath. 1.2 mL (10 mmol) of ethyl trifluoroacetate was diluted with 5 mL of anhydrous ether was diluted and added to the reaction flask. The ice bath was removed and 1.1 mL (10 mmol) acetophenone was diluted with 5 mL of anhydrous ether was diluted and added dropwise to the reaction system using a dropping funnel. The reaction was stirred at reflux for five hours and at the end of the reaction 10 was added mL of water was added to dissolve the resulting solid and the mixture was extracted with ether to remove unreacted ketones and esters. The aqueous phase was acidified with 0.5 mL (10 ) glacial acetic acid was acidified and then extracted with ether in portions, the organic phases were combined, dried with anhydrous magnesium sulfate and filtered. After the filtrate was evaporated from the ether, a light-yellow crystalline low-melting solid powder 1.691 was precipitated. g. The light yellow solid powder was recrystallized with ethanol-water to obtain light yellow pure benzoyltrifluoroacetone.

4,4,4-Trifluoro-1-phenyl-1,3-butanedione synthesis

Synthesis of 4,4,4-Trifluoro-1-phenyl-1,3-butanedione from Ethyl trifluoroacetate and Acetophenone

4,4,4-Trifluoro-1-phenyl-1,3-butanedione Preparation Products And Raw materials

Raw materials

Sodium Acetophenone Ethyl trifluoroacetate

Preparation Products

2-OXO-6-PHENYL-4-(TRIFLUOROMETHYL)-1,2-DIHYDRO-3-PYRIDINECARBONITRILE methyl {[3-cyano-4-(4-methoxyphenyl)-6-phenyl-2-pyridinyl]sulfanyl}acetate

4,4,4-Trifluoro-1-phenyl-1,3-butanedione Suppliers

Global( 285)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1445	60
Sach biotech Co.,Ltd	+8615888865902	sales@hzsqchem.com	China	63	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1803	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29831	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
HaBo Hong Kong Co., Limited.	+86-25-18512596065	info@habotech.com	CHINA	933	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58

Supplier	Advantage
Fluoropharm Co., Ltd.	60
Sach biotech Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Time Chemicals CO., Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Changzhou Ansciep Chemical Co., Ltd.	58
HaBo Hong Kong Co., Limited.	58
Standardpharm Co. Ltd.	58
Alchem Pharmtech,Inc.	58

View Lastest Price from 4,4,4-Trifluoro-1-phenyl-1,3-butanedione manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-06-11	4,4,4-Trifluoro-1-phenyl-1,3-butanedione 326-06-7	US $260.00-220.00 / kg	1kg	98%	5mt	Sach biotech Co.,Ltd
2025-04-04	4,4,4-Trifluoro-1-phenyl-1,3-butanedione 326-06-7	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2019-07-06	BENZOYL-1,1,1-TRIFLUOROACETONE 326-06-7	US $8.00 / kg	1kg	99%	10MT	Career Henan Chemical Co

4,4,4-Trifluoro-1-phenyl-1,3-butanedione
326-06-7
US $260.00-220.00 / kg
98%
Sach biotech Co.,Ltd

4,4,4-Trifluoro-1-phenyl-1,3-butanedione
326-06-7
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

BENZOYL-1,1,1-TRIFLUOROACETONE
326-06-7
US $8.00 / kg
99%
Career Henan Chemical Co

4,4,4-Trifluoro-1-phenyl-1,3-butanedione Spectrum

4,4,4-Trifluoro-1-phenyl-1,3-butanedione(326-06-7)MS 4,4,4-Trifluoro-1-phenyl-1,3-butanedione(326-06-7)¹HNMR 4,4,4-Trifluoro-1-phenyl-1,3-butanedione(326-06-7)¹³CNMR 4,4,4-Trifluoro-1-phenyl-1,3-butanedione(326-06-7)IR1 4,4,4-Trifluoro-1-phenyl-1,3-butanedione(326-06-7)IR2 4,4,4-Trifluoro-1-phenyl-1,3-butanedione(326-06-7)IR3 4,4,4-Trifluoro-1-phenyl-1,3-butanedione(326-06-7)Raman

326-06-7(4,4,4-Trifluoro-1-phenyl-1,3-butanedione)Related Search:

4,4,4-TRIFLUORO-1-(2-NAPHTHYL)-1,3-BUTANEDIONE 4,4,4-TRIFLUORO-1-(4-METHOXYPHENYL)-1,3-BUTANEDIONE 1-(4-CHLOROPHENYL)-4,4,4-TRIFLUORO-1,3-BUTANEDIONE 4,4,4-TRIFLUORO-1-(4-FLUOROPHENYL)BUTANE-1,3-DIONE 4,4,4-Trifluoro-1-phenyl-1,3-butanedione

4,4,4-Trifluoro-1-(p-tolyl)-1,3-butanedione Fluoroacetone Acetone 1,1,1-Trifluoroacetone Benzoylacetone

1-(4-BROMO-PHENYL)-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE 4,4,4-TRIFLUORO-1-(3,4,5-TRIMETHOXYPHENYL)-1,3-BUTANEDIONE 1-(3,4-DIMETHYL-PHENYL)-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE 1-(4-BIPHENYLYL)-4,4,4-TRIFLUORO-1,3-BUTANEDIONE 1-(3-CHLOROPHENYL)-4,4,4-TRIFLUOROBUTANE-1,3-DIONE

1-(4-ETHYL-PHENYL)-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE 4,4,4-trifluoro-1-(2-methylphenyl)butane-1,3-dione 1-(2-CHLOROPHENYL)-4,4,4-TRIFLUOROBUTANE-1,3-DIONE

1of4

TRIFLUORO-1-PHENYL-1,3-BUTANEDIONE 1,1,1-Trifluoro-4-phenyl-2,4-butanedione 1-Benzoyl-3,3,3-trifluoro-2-propanone 1-Benzoyl-3,3,3-trifluoroacetone 4,4,4-Trifluoro-1-phenylbutane-1,3-dione ,98% ω-(Trifluoroacetyl)acetophenone 4,4,4-Trifluoro-1-phenyl-1,3-butanedione,99% 4-Phenyl-1,1,1-trifluorobuta 4,4,4-Trifluoro-1-phenyl-1,3-butanedione 99% 3-BENZOYL-1,1,1-TRIFLUOROACETONE 1,1,1-TRIFLUORO-4-PHENYLBUTANE-2,4-DIONE BENZOYL-1 1 1-TRIFLUOROACETONE 98% Benzoyltrifluoroacetone, 98+% BENZOYL-1,1,1-TRIFLUOROACETONE IN TOLUENE Benzoyl-1,1,1-trifluoroacetone,98% 3-Benzoyl 1,1,1-trifluoroacetate 3-Benzoyl-1,1,1-trifluoroacetone 98% 3-Benzoyl-1,1,1-trifluoroacetone98% 1-Phenyl-4,4,4-trifluorobutane-1,3-dione NSC 405720 NSC 42628 1-Phenyl-4,4,4-trifluoro-1,3-butanedione 4,4,4-trifluoro-1-phenyl-3-butanedione 4-Phenyl-1,1,1-trifluorobutane-2,4-dione Benzoyl(trifluoroacetyl)methane omega-(Trifluoroacetyl)acetophenone w-(Trifluoroacetyl)acetophenone BENZOYL-1,1,1-TRIFLUOROACETONE BENZOYLTRIFLUOROACETONE LABOTEST-BB LT00005189 AKOS MSC-0330 4,4,4-TRIFLUORO-1-PHENYL-1,3-BUTANEDIONE 4,4,4-TRIFLUORO-1-PHENYLBUTANE-1,3-DIONE 1-Phenyl-4,4,4-trifluorobutane-1,3-dione, 2,4-Dioxo-4-phenyl-1,1,1-trifluorobutane Celecoxib Impurity 35 4,4,4-Trifluoro-1-phenylbutane-1,3-dione, 98%, for synthesis 4,4,4-Trifluoro-1-phenyl-1,3-butanedione > 1,3-Butanedione, 4,4,4-trifluoro-1-phenyl- 326-06-7 C6H5COCH2COCF3 Organic Building Blocks Ketones KETONE Building Blocks C10 Carbonyl Compounds organofluorine compounds Miscellaneous