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4,4'-Diamino-3,3'-dimethyldiphenylmethane

4,4'-Diamino-3,3'-dimethyldiphenylmethane structure

CAS No.: 838-88-0

Chemical Name:: 4,4'-Diamino-3,3'-dimethyldiphenylmethane

Synonyms: 4,4'-methylenedi-o-toluidine;mbot;me-mda;Kayahard MDT;4.4'-DiaMino-3;Methylene-bis(2-Methylani;4,4’-methylenedi-o-toluidin;4,4 -Methylendi-o-toluidine;4,4'-METHYLENEBIS-O-TOLUIDINE;4,4'-METHYLENE-DI(O-TOLUIDINE)

CBNumber:: CB5342200

Molecular Formula:: C15H18N2

Molecular Weight:: 226.32

MDL Number:: MFCD00126963

MOL File:: 838-88-0.mol

MSDS File:: SDS

Last updated:2026-09-12 18:53:29

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4,4'-Diamino-3,3'-dimethyldiphenylmethane Properties

Melting point	155-157 °C
Boiling point	357.94°C (rough estimate)
Density	0.9543 (rough estimate)
vapor pressure	1.8hPa at 205.5℃
refractive index	1.5000 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Water Solubility	Insoluble in water
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	5.18±0.25(Predicted)
color	White to Light yellow to Light orange
BRN	398069
Major Application	cleaning products cosmetics environmental food and beverages personal care
InChI	1S/C15H18N2/c1-10-7-12(3-5-14(10)16)9-13-4-6-15(17)11(2)8-13/h3-8H,9,16-17H2,1-2H3
InChIKey	WECDUOXQLAIPQW-UHFFFAOYSA-N
SMILES	Cc1cc(Cc2ccc(N)c(C)c2)ccc1N
Substances of Very High Concern (SVHC) Candidate List	4,4'-methylenedi-o-toluidine (838-88-0)
CAS DataBase Reference	838-88-0(CAS DataBase Reference)
FDA UNII	OM5XWD3S2I
IARC	2B (Vol. 4, Sup 7) 1987
EPA Substance Registry System	4,4'-Methylenebis(2-methylaniline) (838-88-0)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08,GHS09

Signal word

Danger

Hazard statements

H302-H317-H350-H410

Precautionary statements

P202-P273-P280-P301+P312-P302+P352-P308+P313

PPE

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Hazard Codes

T,N

Risk Statements

45-22-43-50/53

Safety Statements

53-45-60-61

RIDADR

UN 3077 9/PG 3

WGK Germany

RTECS

BY5300000

10-23

TSCA

TSCA listed

HazardClass

6.1(b)

PackingGroup

III

HS Code

29215900

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1
Carc. 1B
Skin Sens. 1

REACH Registrations

Active

NFPA 704

	0
1		1

4,4'-Diamino-3,3'-dimethyldiphenylmethane price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	46106	4,4′-Methylene-bis(2-methylaniline) analytical standard	838-88-0	100mg	$84.1	2026-04-30	Buy
TCI Chemical	D2046	4,4'-Diamino-3,3'-dimethyldiphenylmethane >97.0%(T)	838-88-0	25g	$329	2026-04-30	Buy
Biosynth	FD62628	4,4'-Diamino-3,3'-dimethyldiphenylmethane	838-88-0	2g	$347.4	2026-06-04	Buy
Biosynth	FD62628	4,4'-Diamino-3,3'-dimethyldiphenylmethane	838-88-0	5g	$482.5	2026-06-04	Buy
Biosynth	FD62628	4,4'-Diamino-3,3'-dimethyldiphenylmethane	838-88-0	10g	$772	2026-06-04	Buy

Product number	Packaging	Price	Buy
46106	100mg	$84.1	Buy
D2046	25g	$329	Buy
FD62628	2g	$347.4	Buy
FD62628	5g	$482.5	Buy
FD62628	10g	$772	Buy

4,4'-Diamino-3,3'-dimethyldiphenylmethane Chemical Properties,Uses,Production

Chemical Properties

White powder. Soluble in ethanol and hot water.

Uses

4,4′-Methylene-bis(2-methylaniline) has been used as a reference standard for the determination of 4,4′-methylene-bis(2-methylaniline) in plastic multilayer food packaging materials by liquid chromatography (LC)-Orbitrap-full scan-high resolution mass spectrometry (HRMS).
It may be used as a reference standard for the analysis of 4,4′-methylene-bis(2-methylaniline) in dyes, cosmetics, finger paints and inks for pens and tattoos by LC-MS.

Uses

4,4'-Diamino-3,3'-dimethyldiphenylmethane can be used for preparation polyimide and epoxy resin material.

Definition

ChEBI: 4,4'-Methylene bis(2-methylaniline) is a diarylmethane.

General Description

4,4′-Methylene-bis(2-methylaniline) belongs to the primary aromatic amines (PAAs) family of compounds which are toxic in nature and are probable human carcinogens.

Safety Profile

Confirmed carcinogen with experimental carcinogenic data. Moderately toxic by ingestion. An eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Synthesis

50-00-0

95-53-4

4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE

838-88-0

(1) o-toluidine, water and 37% hydrochloric acid were added into the reactor in the ratio of o-toluidine to hydrochloric acid at the molar ratio of 1:1.2 and the weight ratio of o-toluidine to water at the ratio of 1:4, and the reaction was stirred for 30 minutes; (2) the 37% formaldehyde solution was diluted to 10%; (3) the reaction solution from step (1) and the diluted formaldehyde solution from step (2) were transported via advective pumps to each of the microreactor's two inlets, controlling the molar ratio of o-toluidine to formaldehyde to be 3:1; (4) in the microreactor, the two raw materials were contacted, mixed and reacted, the reaction temperature was controlled at 40 °C, the liquid-time air velocity was 3000 h-1, and the reacted solution flowed out from the reactor outlet; (5) the reaction solution was cooled down to room temperature, and the aqueous sodium hydroxide was added dropwise to adjust pH to about 9, and a large amount of white precipitate precipitated, which was filtered, drying to obtain 3,3'-dimethyl-4,4'-diaminodiphenylmethane (MDT) crude product; (6) the crude MDT was recrystallized by ethanol, filtered and dried to obtain the pure MDT with a molar yield of 86% and a purity of 99%.

References

[1] Patent: CN106986777, 2017, A. Location in patent: Paragraph 0043-0055; 0057; 0059; 0061; 0063; 0065
[2] Catalysis Communications, 2014, vol. 45, p. 69 - 73
[3] Journal of the American Chemical Society, 1935, vol. 57, p. 887,889
[4] Journal of the American Chemical Society, 1934, vol. 57, p. 1944
[5] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982, vol. 21, # 8, p. 721 - 723

4,4'-Diamino-3,3'-dimethyldiphenylmethane Preparation Products And Raw materials

Raw materials

Formaldehyde o-Toluidine Hydrochloric acid

Preparation Products

Basic Violet 2

4,4'-Diamino-3,3'-dimethyldiphenylmethane Suppliers

Global( 169)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Thander New Material Science & Technology Co., Ltd	15384069853	2048571647@qq.com	China	472	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Sinopharm Chemical Reagent Co,Ltd.	86-21-63210123	sj_scrc@sinopharm.com	China	9791	79
Maya High Purity Chemicals	+86 (573) 82222445 (0)18006601000 452520369	sales@maya-r.com	China	11693	57
ShangHai YuanYe Biotechnology Co., Ltd.	15026964105	shyysw007@163.com	China	4998	60
Chengdu Ai Keda Chemical Technology Co., Ltd.	4008-755-333 18080918076	800078821@qq.com	China	9706	55

Supplier	Advantage
Nanjing Thander New Material Science & Technology Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Shanghai Hanhong Scientific Co.,Ltd.	64
Sinopharm Chemical Reagent Co,Ltd.	79
Maya High Purity Chemicals	57
ShangHai YuanYe Biotechnology Co., Ltd.	60
Chengdu Ai Keda Chemical Technology Co., Ltd.	55

View Lastest Price from 4,4'-Diamino-3,3'-dimethyldiphenylmethane manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-25	4,4'-Methylene di-o-toluidine 838-88-0	$1.60-6.60	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2024-10-22	4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE 838-88-0	$1.00	1g	85.0-99.8%	20tons	Career Henan Chemica Co
2019-11-08	4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE 838-88-0		1g	98%min	20kg/month	Nanjing jinheyou Trading Co., Ltd.

4,4'-Methylene di-o-toluidine
838-88-0
$1.60-6.60
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE
838-88-0
$1.00
85.0-99.8%
Career Henan Chemica Co

4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE
838-88-0
$0.00
98%min
Nanjing jinheyou Trading Co., Ltd.

4,4'-Diamino-3,3'-dimethyldiphenylmethane Spectrum

4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE(838-88-0)MS 4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE(838-88-0)¹HNMR 4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE(838-88-0)¹³CNMR 4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE(838-88-0)IR1 4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE(838-88-0)IR2

838-88-0(4,4'-Diamino-3,3'-dimethyldiphenylmethane)Related Search:

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4-[(4-aminophenyl)methyl]-2-methylaniline 4,4’-methylenebis(2-methyl-anilin 4,4’-methylenebis(2-methyl-benzenamin 4,4’-methylenebis(2-methylbenzenamine) 4,4’-methylenebis[2-methyl-benzenamin 4,4’-methylenedi-o-toluidin bis(4-amino-3-methylphenyl)-methan bis(4-amino-3-methylphenyl)methane 4,4''-DIAMINO-3,3-DIMETHYLDIPHENYLMETHANE, 95+% 4,4 -Methylendi-o-toluidine 4,4μ-Diamino-3,3μ-dimethyldiphenylmethane, 4,4μ-Methylene-di(o-toluidine) 4-(4-Amino-3-methylbenzyl)-2-methylaniline Kayahard MDT [4-(4-amino-3-methyl-benzyl)-2-methyl-phenyl]amine 4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline 4-[(4-azanyl-3-methyl-phenyl)methyl]-2-methyl-aniline 3,3'-Dimethyl-4,4'-diaminodiphenylmethane 1g [838-88-0] Methylene-bis(2-Methylani 4.4'-DiaMino-3 3,3′-Dimethyl-4,4′-diaminodiphenylmethane Solution, 100ppm 3,3'-diMethyl-4,4'-diaMino-diphenyl Methan bis-4-amino-3-methylfenylmethan mbot me-mda 4,4'-METHYLENE-DI(O-TOLUIDINE) 4,4'-METHYLENEBIS-O-TOLUIDINE 3,3'-DIMETHYL-4,4'-DIAMINODIPHENYLMETHANE 4-(4-amino-3-methylbenzyl)-2-methylbenzenamine 3,3'-Dimethyl-4,4'-diaminobiphenylmethane 4,4-DIAMINO-3,3-DIMETHYLDIPHENYL- METHAN 4,4-METHYLENE-BIS(2-METHYLANILINE),STAND ARD FOR GC 2,2'-Dimethyl-4,4'-methylenedianiline 4,4'-Methylenebis(2-methylbenzeneamine) Bis(3-methyl-4-aminophenyl) methane 3,3'-Dimethyl-4,4'-diaminodiphenylmethane@10 μg/mL in Ethyl acetate 3,3'-Dimethyl-4,4'-diaminodiphenylmethane@100 μg/mL in AcCN 3,3'-Dimethyl-4,4'-diaminodiphenylmethane@1000 μg/mL in AcCN 4,4'-Diamino-3,3'-dimethyldiphenylmethane> Benzenamine, 4,4'-methylenebis[2-methyl- 4,4'-Diamino-3,3'-dimethyldiphenylmethane Solution in Methanol, 100μg/mL 4,4'-Methylenbis(2-methyl)-benzolamin 4,4'-Methylene-bis(2-methylaniline) 3,3'-diMethyl-4,4'-diaMino-diphenyl Methane 3,3-Dimethyl-4,4-diaminodiphenylmethane in acetonitrile 3,3-Dimethyl-4,4-diaminodiphenylmethane in isooctane 4,4'-Diamino-3,3'-dimethyldiphenylmethane 100 μg/ml Acetonitrile 4.4‘-Diamino-3.3‘-dimethyldiphenyl methane 100ug/mL C12194800 4.4’-Diamino-3.3’-dimethyldiphenyl 4,4'-(1-Methylethylidene)diphenol 4,4′-Methylene-bis(2-methylaniline), CAS 838-88-0 4,4′-Methylene-bis(2-methylaniline) 4,4'-Diamino-3,3'-dimethyldiphenyl methane 100 μg/mL in Acetonitrile 4,4'-methylenedi-o-toluidine 4,4'-Diamino-3,3'-dimethyldiphenylmethane 838-88-0 Analytical Chromatography Product Catalog Alphabetic Analytical Standards