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Z-CIS-HYP-OH

Z-CIS-HYP-OH structure

CAS No.: 13504-86-4

Chemical Name:: Z-CIS-HYP-OH

Synonyms: Z-CIS-HYP-OH;Z-L-CIS-HYP-OH;Z-cis-L-Hyp-OH;CBZ-cis-Hyp-OH;Z-CIS-HYDROXYPROLINE;Z-L-CIS-4-HYDROXYPROLINE;Z-CIS-4-HYDROXY-L-PROLINE;Z-L-cis-4-hydroxyproline99%;cis-N-Cbz-4-hydroxy-L-proline;N-Cbz-4-cis-Hydroxy-L-proline

CBNumber:: CB5349906

Molecular Formula:: C13H15NO5

Molecular Weight:: 265.26

MDL Number:: MFCD00238423

MOL File:: 13504-86-4.mol

MSDS File:: SDS

Last updated:2026-05-28 05:31:47

Product description	Number	Pack Size	Price
Z-L-cis-4-hydroxyproline Asreported	279910	500mg	$382
Z-L-cis-4-hydroxyproline Asreported	279910	1g	$674
Z-L-cis-4-hydroxyproline Asreported	279910	2g	$958
Z-L-cis-4-hydroxyproline Asreported	279910	5g	$1546
Z-L-cis-4-hydroxyproline Asreported	279910	10g	$2269
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Z-CIS-HYP-OH Properties

Boiling point	486.9±45.0 °C(Predicted)
Density	1.416±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	3.78±0.40(Predicted)
Appearance	White to off-white Solid
optical activity	-37.8°(C=0.01g/ml MEOH)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P301+P312-P302+P352-P304+P340-P305+P351+P338
HazardClass	IRRITANT

Z-CIS-HYP-OH price More Price(69)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	279910	Z-L-cis-4-hydroxyproline Asreported	13504-86-4	500mg	$382	2026-06-03	Buy
Usbiological	279910	Z-L-cis-4-hydroxyproline Asreported	13504-86-4	1g	$674	2026-06-03	Buy
Usbiological	279910	Z-L-cis-4-hydroxyproline Asreported	13504-86-4	2g	$958	2026-06-03	Buy
Usbiological	279910	Z-L-cis-4-hydroxyproline Asreported	13504-86-4	5g	$1546	2026-06-03	Buy
Usbiological	279910	Z-L-cis-4-hydroxyproline Asreported	13504-86-4	10g	$2269	2026-06-03	Buy

Product number	Packaging	Price	Buy
279910	500mg	$382	Buy
279910	1g	$674	Buy
279910	2g	$958	Buy
279910	5g	$1546	Buy
279910	10g	$2269	Buy

Z-CIS-HYP-OH Chemical Properties,Uses,Production

Synthesis

117811-78-6

13504-86-4

General procedure for the synthesis of (2S,4S)-N-Cbz-4-hydroxypyrrolidine-2-carboxylic acid from (2S,4R)-Cbz-4-methanesulfonyloxyproline methyl ester: firstly, 708 g of water and 337 g of 48% sodium hydroxide solution were added to 928 g of the crude product obtained by reference to Example 3. The temperature of the mixture was raised to 80°C and the reaction was ripened at this temperature for 3 hours. Upon completion of the maturation, the temperature was kept constant and 146 g of solvent was distilled under reduced pressure until the pressure was reduced to 13 kPa. Subsequently, the mixture was cooled to 20°C, 180 g of 48% sodium hydroxide solution was added and aged at 25°C for 12 hours. The amount of cis-Benzyloxycarbonyl-4-hydroxy-L-proline in the reaction solution was determined by analysis to be 2.19 mol (81.0% yield based on trans-4-hydroxy-L-proline). Next, 35 g of toluene was added to the hydrolysis reaction solution and the mixture was concentrated under reduced pressure at 7 kPa and 40 °C to distill 332 g of solvent. Then, 161 g of concentrated sulfuric acid was added dropwise to the concentrated solution and the pH was adjusted to 1.3. After acidic adjustment, 710 g of tetrahydrofuran and 354 g of water were added for layered separation. To the separated water layer, 356 g of tetrahydrofuran was added and the separation was performed again. All the separated tetrahydrofuran layers were combined and concentrated at 40 °C under reduced pressure at 26 kPa, resulting in 896 g of concentrate containing 2.12 mol of cis-Benzyloxycarbonyl-4-hydroxy-L-proline (90.2% yield) with a cis/trans ratio of 98.3/1.7.

References

[1] Patent: JP5703654, 2015, B2. Location in patent: Paragraph 0054; 0055

Z-CIS-HYP-OH synthesis

Synthesis of Z-CIS-HYP-OH from L-ZHPROMSME

Z-CIS-HYP-OH Preparation Products And Raw materials

Raw materials

L-ZHPROMSME

Preparation Products

1,2-Pyrrolidinedicarboxylic acid, 4-methoxy-, 1-(phenylmethyl) ester, (2S,4S)-

Z-CIS-HYP-OH Suppliers

Global( 77)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	9976	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58
Sichuan Biosynce Pharmatech Co., Ltd.	+8619950309693	diane@biosynce.com	China	4871	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Fuxin Pharmaceutical	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Nextpeptide Inc	58
Sichuan Biosynce Pharmatech Co., Ltd.	58

View Lastest Price from Z-CIS-HYP-OH manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-02-14	Z-CIS-HYP-OH 13504-86-4	$7.00	1KG	99%	100kg	Career Henan Chemical Co

Z-CIS-HYP-OH
13504-86-4
$7.00
99%
Career Henan Chemical Co

Z-CIS-HYP-OH Spectrum

Z-CIS-HYP-OH(13504-86-4)¹HNMR

13504-86-4(Z-CIS-HYP-OH)Related Search:

Z-CYS(BZL)-OH Z-HYP-OH Z-D-PRO-OTBU FMOC-D-CIS-HYP-OH H-DL-cis-Hyp-OH

CIS-4-HYDROXY-L-PROLINE[CIS-HYP-OH], Z-D-CIS-HYP-OH (S)-1-CBZ-2-HYDROXYMETHYLPYRROLIDINE Z-L-PROLINE Z-CIS-HYP-OH

N-ME-CIS-HYP-OH CIS-ZHPROME (S)-1-CBZ-3-PYRROLIDINOL 95 3-HYDROXY-1-N-CBZ-PYRROLIDINE cis-4-Hydroxy-D-proline

cis-4-Hydroxy-L-proline Z-D-ALA-OSU Z-D-ALA-GLY-OH

1of4

N-ALPHA-CARBOBENZOXY-CIS-4-HYDROXY-L-PROLINE Z-L-CIS-4-HYDROXYPROLINE cis-N-Cbz-4-hydroxy-L-proline (2S,4S)-N-Cbz-trans-4-hydroxy-L-proline Z-L-CIS-HYP-OH Z-CIS-4-HYDROXY-L-PROLINE Z-CIS-HYDROXYPROLINE Z-CIS-HYP-OH (2S,4S)-N-ALPHA-CARBOBENZOXY-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID cis-N-alpha-Benzyloxycarbonyl-L-hydroxyproline, (2S,4S)-N-Benzyloxycarbonyl-4-hydroxy-2-pyrrolinecarboxylic acid (2S,4S)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid hydrogen 1-(phenylmethyl) ester 1-(Benzyloxycarbonyl)-4α-hydroxy-L-proline CIS-N-ALPHA-BENZYLOXYCARBONYL-L-HYDROXYPROLINE (2S,4S)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic (2S,4S)-4-hydroxy-1,2-Pyrrolidinedicarboxylic acid 1-(phenylmethyl) ester Z-cis-L-Hyp-OH Z-L-cis-4-hydroxyproline99% CBZ-cis-Hyp-OH N-Cbz-4-cis-Hydroxy-L-proline 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(phenylmethyl) ester, (2S,4S)- (2S,4S)-1-(Benzyloxycarbonyl)-2-(carboxy)-4-hydroxypyrrolidine (4S)-N-Cbz-4-hydroxy-D-proline (2S, 4S)-l-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carbox (2S,4S)-1-benzyloxycarbonyl-4-hydroxyproline (2S,4S)-4-hydroxy-1-phenylmethoxycarbonylpyrrolidine-2-carboxylic acid (2S,4S)-N-Cbz-cis-4-hydroxy-L-proline 13504-86-4