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Z-cis-Hyp-OH

Z-cis-Hyp-OH structure

CAS No.: 13504-86-4

Chemical Name:: Z-cis-Hyp-OH

Synonyms: Z-cis-Hyp-OH;Z-L-CIS-HYP-OH;Z-cis-L-Hyp-OH;CBZ-cis-Hyp-OH;Z-CIS-HYDROXYPROLINE;Z-L-CIS-4-HYDROXYPROLINE;Z-CIS-4-HYDROXY-L-PROLINE;Z-L-cis-4-hydroxyproline99%;cis-N-Cbz-4-hydroxy-L-proline;N-Cbz-4-cis-Hydroxy-L-proline

CBNumber:: CB5349906

Molecular Formula:: C13H15NO5

Molecular Weight:: 265.26

MDL Number:: MFCD00238423

MOL File:: 13504-86-4.mol

MSDS File:: SDS

Last updated:2026-09-12 18:53:30

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Z-cis-Hyp-OH Properties

Melting point	105-107 °C
Boiling point	486.9±45.0 °C(Predicted)
Density	1.416±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	3.78±0.40(Predicted)
Appearance	White to off-white Solid
optical activity	-37.8°(C=0.01g/ml MEOH)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P301+P312-P302+P352-P304+P340-P305+P351+P338
HazardClass	IRRITANT

Z-cis-Hyp-OH price More Price(53)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	279910	Z-L-cis-4-hydroxyproline Asreported	13504-86-4	500mg	$382	2026-06-03	Buy
Usbiological	279910	Z-L-cis-4-hydroxyproline Asreported	13504-86-4	1g	$674	2026-06-03	Buy
Usbiological	279910	Z-L-cis-4-hydroxyproline Asreported	13504-86-4	2g	$958	2026-06-03	Buy
Usbiological	279910	Z-L-cis-4-hydroxyproline Asreported	13504-86-4	5g	$1546	2026-06-03	Buy
Usbiological	279910	Z-L-cis-4-hydroxyproline Asreported	13504-86-4	10g	$2269	2026-06-03	Buy

Product number	Packaging	Price	Buy
279910	500mg	$382	Buy
279910	1g	$674	Buy
279910	2g	$958	Buy
279910	5g	$1546	Buy
279910	10g	$2269	Buy

Z-cis-Hyp-OH Chemical Properties, Uses, Production

Synthesis

117811-78-6

13504-86-4

General procedure for the synthesis of (2S,4S)-N-Cbz-4-hydroxypyrrolidine-2-carboxylic acid from (2S,4R)-Cbz-4-methanesulfonyloxyproline methyl ester: firstly, 708 g of water and 337 g of 48% sodium hydroxide solution were added to 928 g of the crude product obtained by reference to Example 3. The temperature of the mixture was raised to 80°C and the reaction was ripened at this temperature for 3 hours. Upon completion of the maturation, the temperature was kept constant and 146 g of solvent was distilled under reduced pressure until the pressure was reduced to 13 kPa. Subsequently, the mixture was cooled to 20°C, 180 g of 48% sodium hydroxide solution was added and aged at 25°C for 12 hours. The amount of cis-Benzyloxycarbonyl-4-hydroxy-L-proline in the reaction solution was determined by analysis to be 2.19 mol (81.0% yield based on trans-4-hydroxy-L-proline). Next, 35 g of toluene was added to the hydrolysis reaction solution and the mixture was concentrated under reduced pressure at 7 kPa and 40 °C to distill 332 g of solvent. Then, 161 g of concentrated sulfuric acid was added dropwise to the concentrated solution and the pH was adjusted to 1.3. After acidic adjustment, 710 g of tetrahydrofuran and 354 g of water were added for layered separation. To the separated water layer, 356 g of tetrahydrofuran was added and the separation was performed again. All the separated tetrahydrofuran layers were combined and concentrated at 40 °C under reduced pressure at 26 kPa, resulting in 896 g of concentrate containing 2.12 mol of cis-Benzyloxycarbonyl-4-hydroxy-L-proline (90.2% yield) with a cis/trans ratio of 98.3/1.7.

References

[1] Patent: JP5703654, 2015, B2. Location in patent: Paragraph 0054; 0055

Z-cis-Hyp-OH synthesis

Synthesis of Z-cis-Hyp-OH from L-ZHPROMSME

Z-cis-Hyp-OH Preparation Products And Raw materials

Raw materials

L-ZHPROMSME

Preparation Products

1,2-Pyrrolidinedicarboxylic acid, 4-methoxy-, 1-(phenylmethyl) ester, (2S,4S)-

Z-cis-Hyp-OH Suppliers

Global Suppliers ( 76)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
PharmaBlock Sciences (Nanjing),Inc.	025-86918202 4000255188	sales@pharmablock.com	China	5000	55
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
ChemFuture PharmaTech (Jiangsu) Ltd	5108538618	suger.wang@chemfuture.com	China	832	65
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15350	60
Chengdu HappySyn Pharmaceutical Technology Co., Ltd.	85114309 18982182443	yangli@happysyn.com	China	2284	55
ShenZhen InnoSyn Biotech Co.,Ltd	0755-28351685 18503098468	innosyn@163.com	China	602	55
SynAsst Chemical.	021-60343070		China	12731	55
Shanghai Yolne Chemical Co., Ltd.	021-62960152	934678158@qq.com	China	9886	55

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
PharmaBlock Sciences (Nanjing),Inc.	55
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
ChemFuture PharmaTech (Jiangsu) Ltd	65
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky (shanghai) International Co.,Ltd	60
Chengdu HappySyn Pharmaceutical Technology Co., Ltd.	55
ShenZhen InnoSyn Biotech Co.,Ltd	55
SynAsst Chemical.	55
Shanghai Yolne Chemical Co., Ltd.	55

View Latest Price from Z-cis-Hyp-OH manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-02-14	Z-CIS-HYP-OH 13504-86-4	$7.00	1KG	99%	100kg	Career Henan Chemical Co

Z-CIS-HYP-OH
13504-86-4
$7.00
99%
Career Henan Chemical Co

Z-cis-Hyp-OH Spectrum

Z-CIS-HYP-OH(13504-86-4)¹HNMR

13504-86-4 (Z-cis-Hyp-OH) Related Search:

Z-D-Pro-OtBu Z-Cys(Bzl)-OH Z-Hyp-OH Fmoc-D-cis-Hyp-OH Z-L-proline

cis-4-Hydroxy-L-proline cis-4-Hydroxy-D-proline H-DL-cis-Hyp-OH CIS-ZHPROME cis-4-Hydroxy-L-proline[cis-Hyp-OH],

N-Me-cis-hydroxyproline Z-cis-Hyp-OH Z-D-cis-Hyp-OH 3-Hydroxy-1-N-Cbz-pyrrolidine (S)-1-Cbz-2-hydroxymethylpyrrolidine

(S)-1-Cbz-3-pyrrolidinol 95 Z-D-Ala-OSu Z-D-Ala-Gly-OH

1of4

N-ALPHA-CARBOBENZOXY-CIS-4-HYDROXY-L-PROLINE Z-L-CIS-4-HYDROXYPROLINE cis-N-Cbz-4-hydroxy-L-proline (2S,4S)-N-Cbz-trans-4-hydroxy-L-proline Z-L-CIS-HYP-OH Z-CIS-4-HYDROXY-L-PROLINE Z-CIS-HYDROXYPROLINE (2S,4S)-N-ALPHA-CARBOBENZOXY-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID cis-N-alpha-Benzyloxycarbonyl-L-hydroxyproline, (2S,4S)-N-Benzyloxycarbonyl-4-hydroxy-2-pyrrolinecarboxylic acid (2S,4S)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid hydrogen 1-(phenylmethyl) ester 1-(Benzyloxycarbonyl)-4α-hydroxy-L-proline CIS-N-ALPHA-BENZYLOXYCARBONYL-L-HYDROXYPROLINE (2S,4S)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic (2S,4S)-4-hydroxy-1,2-Pyrrolidinedicarboxylic acid 1-(phenylmethyl) ester Z-cis-L-Hyp-OH Z-L-cis-4-hydroxyproline99% CBZ-cis-Hyp-OH N-Cbz-4-cis-Hydroxy-L-proline 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(phenylmethyl) ester, (2S,4S)- (2S,4S)-1-(Benzyloxycarbonyl)-2-(carboxy)-4-hydroxypyrrolidine (4S)-N-Cbz-4-hydroxy-D-proline (2S, 4S)-l-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carbox (2S,4S)-1-benzyloxycarbonyl-4-hydroxyproline (2S,4S)-4-hydroxy-1-phenylmethoxycarbonylpyrrolidine-2-carboxylic acid (2S,4S)-N-Cbz-cis-4-hydroxy-L-proline Z-cis-Hyp-OH 13504-86-4