CIS-ZHPROME
- CAS No.
- 57653-35-7
- Chemical Name:
- CIS-ZHPROME
- Synonyms
- CIS-ZHPROME;CIS-ZHPROME USP/EP/BP;Cbz-cis-4-Hydroxy-L-Proline methyl ester;N-CBZ-CIS-4-HYDROXY-L-PROLINE METHYL ESTER;(4S)-1-Cbz-4-hydroxy-L-proline methyl ester;(2S,4S)-N-Cbz-cis-4-hydroxy-L-proline methyl ester;N-CARBOBENZYLOXY-(4S)-HYDROXY-L-PROLINE METHYL ESTER;Methyl (2S,4S)-1-Cbz-4-Hydroxypyrrolidine-2-carboxylate;O1-benzyl O2-methyl (2S,4S)-4-hydroxypyrrolidine-1,2-dic;(2S,4S)-1-Benzyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate
- CBNumber:
- CB72453344
- Molecular Formula:
- C14H17NO5
- Molecular Weight:
- 279.29
- MDL Number:
- MFCD09954934
- MOL File:
- 57653-35-7.mol
- MSDS File:
- SDS
| Melting point | 80-85°C |
|---|---|
| Boiling point | 422.8±45.0 °C(Predicted) |
| Density | 1.313±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | solid |
| pka | 14.25±0.40(Predicted) |
| Appearance | White to off-white Solid |
| InChI | 1S/C14H17NO5/c1-19-13(17)12-7-11(16)8-15(12)14(18)20-9-10-5-3-2-4-6-10/h2-6,11-12,16H,7-9H2,1H3/t11-,12-/m0/s1 |
| InChIKey | VVKAGQHUUDRPOI-RYUDHWBXSA-N |
| SMILES | COC(=O)[C@@H]1C[C@H](O)CN1C(=O)OCc2ccccc2 |
| UNSPSC Code | 12352209 |
| NACRES | NA.22 |
CIS-ZHPROME price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 705934 | N-Cbz-cis-4-Hydroxy-L-proline methyl ester 97% | 57653-35-7 | 1g | $233 | 2026-04-30 | Buy |
| Matrix Scientific | 122487 | N-Cbz-cis-4-Hydroxy-L-proline methyl ester | 57653-35-7 | 1.00g | $116 | 2026-05-18 | Buy |
| Synthonix | H10333 | O1-Benzyl O2-methyl (2S,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate 97.0% | 57653-35-7 | 1g | $102 | 2026-05-06 | Buy |
| Synthonix | H10333 | O1-Benzyl O2-methyl (2S,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate 97.0% | 57653-35-7 | 5g | $121 | 2026-05-06 | Buy |
| Synthonix | H10333 | O1-Benzyl O2-methyl (2S,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate 97.0% | 57653-35-7 | 10g | $130 | 2026-05-06 | Buy |
CIS-ZHPROME Chemical Properties, Uses, Production
Synthesis
1527519-52-3
57653-35-7
Potassium carbonate (9.1 g, 65.8 mmol) was added to a solution of compound D (23 g, 65.8 mmol) in methanol (100 mL) at 0 °C and the reaction mixture was stirred at room temperature for 1 hour. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the mixture was filtered. The filtrate was concentrated under vacuum to remove methanol, and the residue was dissolved in ethyl acetate, washed sequentially with water and brine, dried over anhydrous magnesium sulfate, filtered and concentrated to give the crude product. The crude product was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 4/1 to 1/1 gradient elution) to afford the target product (2S,4S)-N-CBZ-4-hydroxyproline methyl ester (12.6 g, 70% yield) as a light yellow oil.
References
[1] Patent: WO2014/32, 2014, A1. Location in patent: Page/Page column 59
CIS-ZHPROME Preparation Products And Raw materials
Raw materials
Preparation Products
CIS-ZHPROME Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| SpringPharma Tech Co.,Ltd | +86-25-68710855, +86-25-68710897 | sales@springpharma.net | China | 1260 | 62 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Beijing FYF Chemicals Co., Ltd | 010-57903446 15869909019 | 168931144@qq.com | China | 2876 | 58 |
| Chengdu Chuangkecheng Biological Technology Co., Ltd. | 028-028-0000000 13008177686 | sales@ckcbiotech.com | China | 899 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shandong Xiya Chemical Co., Ltd. | 4009903999 13395398332 | sales@xiyashiji.com | China | 20788 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
