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4'-Chloropivaloanilide

4'-Chloropivaloanilide Structure
4'-Chloropivaloanilide structure
CAS No.
65854-91-3
Chemical Name:
4'-Chloropivaloanilide
Synonyms
4-Chloropivalamide;4-Chloropivalanilide;4'-Chloropivaloanilide;N-Pivaloyl-p-chlorophenyl;4'-Chloropivaloanilide>4-CHLORO-N-PIVALOYLANILINE;N-PIVALOYL-P-CHLOROANILINE;N-(4-chlorophenyl)pivalaMide;N-(4-CHLOROPHENYL)PIVALOYLAMIDE;4''-CHLOROPIVALOANILIDE,98.0%+(GC)
CBNumber:
CB5365717
Molecular Formula:
C11H14ClNO
Molecular Weight:
211.69
MDL Number:
MFCD00095895
MOL File:
65854-91-3.mol
MSDS File:
SDS
Last updated:2026-09-12 18:53:31
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4'-Chloropivaloanilide Properties

Melting point 152 °C
Boiling point 352.1±25.0 °C(Predicted)
Density 1.150±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka 14.25±0.70(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332
Precautionary statements  P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P501
HS Code  2921420090
NFPA 704
0
1 0

4'-Chloropivaloanilide price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S902640 4'-CHLORO-2,2-DIMETHYLPROPIONANILIDE AldrichCPR 65854-91-3 1 unit $32.7 2026-04-30 Buy
Sigma-Aldrich S902640 4'-CHLORO-2,2-DIMETHYLPROPIONANILIDE Aldrich 65854-91-3 50mg $29.8 2024-03-01 Buy
TCI Chemical C2099 4'-Chloropivaloanilide >98.0%(GC) 65854-91-3 25g $30 2026-04-30 Buy
TCI Chemical C2099 4'-Chloropivaloanilide >98.0%(GC) 65854-91-3 250g $250 2026-04-30 Buy
Apolloscientific OR11237 N-Pivaloyl-p-chloroaniline 99% 65854-91-3 5g $21 2026-06-04 Buy
Product number Packaging Price Buy
S902640 1 unit $32.7 Buy
S902640 50mg $29.8 Buy
C2099 25g $30 Buy
C2099 250g $250 Buy
OR11237 5g $21 Buy

4'-Chloropivaloanilide Chemical Properties, Uses, Production

Synthesis

Pivaloyl chloride

3282-30-2

4-Chloroaniline

106-47-8

4'-CHLOROPIVALOANILIDE

65854-91-3

The general procedure for synthesizing N-pivaloyl-p-chloroaniline from pivaloyl chloride and 4-chloroaniline was as follows: referring to Example 2, 4-chloroaniline (113 kg, 886 mol), deionized water (565 L), and sodium bicarbonate (89.3 kg, 1.2 eq.) were added to ethyl acetate (1695 L). Pivaloyl chloride (112 kg, 1.05 eq.) was slowly added dropwise at 15°C or lower. After the dropwise addition was completed, the reaction solution was stirred at about 25°C for 2 hours. Upon completion of the reaction, the organic and aqueous layers were separated. The organic layer was washed twice with deionized water (848 L x 2) and then concentrated under reduced pressure to about 600 L. To the concentrate was added ethylcyclohexane (848 L) and again concentrated under reduced pressure to about 600 L. The residue was cooled to about 5 °C and stirred for 1 h to promote crystallization. The precipitated crystals were collected by filtration and dried under reduced pressure to afford N-pivaloyl-p-chloroaniline (187 kg, 99.7% yield).

References

[1] Patent: WO2005/121133, 2005, A1. Location in patent: Page/Page column 30-31
[2] Patent: US2009/247766, 2009, A1. Location in patent: Page/Page column 27
[3] Patent: WO2015/118515, 2015, A1. Location in patent: Page/Page column 9
[4] Journal of Organic Chemistry, 1998, vol. 63, # 23, p. 8536 - 8543
[5] Patent: CN105801442, 2016, A. Location in patent: Paragraph 0006; 0018; 0022; 0026; 0030

4'-Chloropivaloanilide Preparation Products And Raw materials

Raw materials

2,2,2-Trimethylacetanilide tert-Butyl methyl ether Pivaloyl chloride 4-Chloroaniline Ethyl acetate
Sodium bicarbonate

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Preparation Products

1-(2-Amino-5-chlorophenyl)-2,2,2-trifluoroethanone

4'-Chloropivaloanilide Suppliers

Global Suppliers ( 99)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
ZHIWE CHEMTECH CO LTD 021-20221225 13917446399 zwchem@163.com China 522 61
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Ark Pharm, Inc. 847-367-3680 sales@arkpharminc.com United States 1669 56
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Maya High Purity Chemicals +86 (573) 82222445 (0)18006601000 452520369 sales@maya-r.com China 11693 57
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 13913916777 cfzhang@aikonchem.com China 19902 55
TOKYO CHEMICAL INDUSTRY CO., LTD. 03-36680489 Sales-JP@TCIchemicals.com Japan 28364 80
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
ZHIWE CHEMTECH CO LTD 61
TCI (Shanghai) Development Co., Ltd. 81
Ark Pharm, Inc. 56
Energy Chemical 61
Shandong Xiya Chemical Co., Ltd 57
Maya High Purity Chemicals 57
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 55
TOKYO CHEMICAL INDUSTRY CO., LTD. 80

View Latest Price from 4'-Chloropivaloanilide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4'-CHLOROPIVALOANILIDE pictures 2020-01-13 4'-CHLOROPIVALOANILIDE
65854-91-3
 $1.00 1KG 99% 100KG Career Henan Chemical Co

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N-PIVALOYL-P-CHLOROANILINE N-(4-CHLOROPHENYL)-2,2-DIMETHYLPROPIONAMIDE N-(4-CHLOROPHENYL)PIVALOYLAMIDE 4-Chloropivalanilide 4''-CHLOROPIVALOANILIDE,98.0%+(GC) N-Pivaloyl-p-chlorophenyl 4-CHLORO-N-PIVALOYLANILINE N-(4-Chlorophenyl)-2,2-dimethylpropanamide 4-Chloro-N-pivaloylaniline N-(4-Chlorophenyl)pivaloylamide N-(4-Chlorophenyl)-2,2-dimethylpropionamide N-(4-chlorophenyl)pivalaMide 4'-CHLORO-2,2-DIMETHYLPROPIONANILIDE 4-Chloropivalamide 4'-Chloropivaloanilide> Propanamide, N-(4-chlorophenyl)-2,2-dimethyl- 4'-CHLORO-2,2-DIMETHYLPROPIONANILIDE 4′-Chloropivaloanilide, CAS 65854-91-3 4'-Chloropivaloanilide 65854-91-3