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4-Bromo-1,2-(methylenedioxy)benzene

4-Bromo-1,2-(methylenedioxy)benzene structure

CAS No.: 2635-13-4

Chemical Name:: 4-Bromo-1,2-(methylenedioxy)benzene

Synonyms: 5-bromobenzo[d][1,3]dioxole;5-BROMO-1,3-BENZODIOXOLE;1,2-METHYLENEDIOXY-4-BROMOBENZENE;4-BROMO-1,2-METHYLENEDIOXYBENZENE;1-BROMO-3,4-(METHYLENEDIOXY)BENZENE;1-Bromo-3,4-(methylenedioxy)benzene 97%;enedioxy)benzene;BROMOBENZODIOXOLE;TIMTEC-BB SBB006662;4-Bromo-1,2-(methyL

CBNumber:: CB5398696

Molecular Formula:: C7H5BrO2

Molecular Weight:: 201.02

MDL Number:: MFCD00005821

MOL File:: 2635-13-4.mol

MSDS File:: SDS

Last updated:2026-05-28 03:29:40

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4-Bromo-1,2-(methylenedioxy)benzene Properties

Boiling point	85-86 °C1 mm Hg(lit.)
Density	1.669 g/mL at 25 °C(lit.)
refractive index	n20/D 1.583(lit.)
Flash point	>230 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform, Methanol (Sparingly)
form	Liquid
Specific Gravity	1.669
color	Clear yellow-orange
BRN	127407
Stability	Light Sensitive
InChI	InChI=1S/C7H5BrO2/c8-5-1-2-6-7(3-5)10-4-9-6/h1-3H,4H2
InChIKey	FBOYMIDCHINJKC-UHFFFAOYSA-N
SMILES	O1C2=CC=C(Br)C=C2OC1
CAS DataBase Reference	2635-13-4(CAS DataBase Reference)
NIST Chemistry Reference	4-Bromo-1,2-(methylenedioxy)benzene(2635-13-4)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-37/39

WGK Germany

Hazard Note

Irritant

HS Code

29329990

Storage Class

10 - Combustible liquids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

4-Bromo-1,2-(methylenedioxy)benzene price More Price(81)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	288314	1-Bromo-3,4-(methylenedioxy)benzene 97%	2635-13-4	25g	$122	2026-04-30	Buy
Sigma-Aldrich	288314	1-Bromo-3,4-(methylenedioxy)benzene 97%	2635-13-4	100g	$186	2026-04-30	Buy
TCI Chemical	B1230	4-Bromo-1,2-methylenedioxybenzene >98.0%(GC)	2635-13-4	5g	$34	2026-04-30	Buy
TCI Chemical	B1230	4-Bromo-1,2-methylenedioxybenzene >98.0%(GC)	2635-13-4	25g	$89	2026-04-30	Buy
Strem Chemicals	06-0037	5-Bromo-1,3-benzodioxole, min. 98% min.98%	2635-13-4	25g	$73	2026-04-30	Buy

Product number	Packaging	Price	Buy
288314	25g	$122	Buy
288314	100g	$186	Buy
B1230	5g	$34	Buy
B1230	25g	$89	Buy
06-0037	25g	$73	Buy

4-Bromo-1,2-(methylenedioxy)benzene Chemical Properties, Uses, Production

Chemical Properties

clear yellow-orange liquid

Uses

The coupling of 1-bromo-3,4-(methylenedioxy)benzene with β-methallyl alcohol was catalyzed by Pd(OAc)₂ in combination with P(t-Bu)₃.

Synthesis Reference(s)

Tetrahedron, 64, p. 4999, 2008 DOI: 10.1016/j.tet.2008.03.085

General Description

The coupling of 1-bromo-3,4-(methylenedioxy)benzene with β-methallyl alcohol was catalyzed by Pd(OAc)₂ in combination with P(t-Bu)₃.

Synthesis

NBS (1.87 g, 10.50 mmol, 1.05 equiv.), HPLC-grade acetonitrile and benzo[d][1,3]dioxole (10 mmol) were placed into a flask and stirred until completely homogeneous. The solution was pumped through the Corning G1 photoreactor at the desired flow rate. The reaction mixture was collected from the reactor and combined with the two separate streams of toluene and water into a 10-mL Vapourtec static mixer coil; then, the mixture was pumped into a Zaiput liquid-liquid membrane separator, the organic phase was collected and passed twice more through the Zaiput membrane separator. The organic phase was evaporated under reduced pressure, providing the corresponding brominated product 4-Bromo-1,2-(methylenedioxy)benzene.

References

[1] Tetrahedron Letters, 2001, vol. 42, # 39, p. 6941 - 6942
[2] Angewandte Chemie - International Edition, 2018, vol. 57, # 39, p. 12869 - 12873
[3] Angew. Chem., 2018, vol. 130, p. 13051 - 13055,5
[4] Organic Letters, 2017, vol. 19, # 16, p. 4243 - 4246
[5] Canadian Journal of Chemistry, 2009, vol. 87, # 2, p. 440 - 447

4-Bromo-1,2-(methylenedioxy)benzene synthesis

Synthesis of 4-Bromo-1,2-(methylenedioxy)benzene from N-Bromosuccinimide and 1,3-Benzodioxole

4-Bromo-1,2-(methylenedioxy)benzene Preparation Products And Raw materials

Raw materials

1,3-Benzodioxole N-Bromosuccinimide Chloroform

Preparation Products

3,4-Methylenedioxyphenylboronic acid PIPERONALDOXIME 1-Iodo-3,4-methylenedioxybenzene 5-Bromo-4-iodo-1,3-benzodioxole 3,4-(Methylenedioxy)thiophenol

3,4-(Methylenedioxy)aniline

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4-Bromo-1,2-(methylenedioxy)benzene Suppliers

Global Suppliers ( 358)

Supplier	Tel	Email	Country	ProdList	Advantage
Shijiazhuang Benchu Technology Co., Ltd.	0311-680150596798-6798 17367983103	925646462@qq.com	China	29	58
Dafeng Newti Pharmaceutical Technology Co., Ltd.	0512-65916026 18015586221	2760994703@qq.com	China	265	55
Taizhou Chuangyuan Industrial Technology Co. Ltd.	0576-85289468; 13757609826	sales@tzchemical.com	China	254	58
Shaoxing Fangxiao Chemical Co., LTD	+86-13456999252; 13456999252	shellyhouse39@126.com	China	41	58
Cdreamlab (Hubei) Technology Co., LTD	18062399888; 18062399888	service@cdreamlab.com	China	129	58
Suzhou Haihe Pharmaceutical Technology Co., Ltd.	13816002113	68249111@qq.com	China	51	58
Chengdu jingzhihuacheng Chemical Technology Co., Ltd.	028-37664989 15900794981	873239557@qq.com	China	1050	58
Changzhou Wanyao Biotechnology Co., Ltd.	0519-89185693 15312551983	2410037592@qq.com	China	278	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62

Supplier	Advantage
Shijiazhuang Benchu Technology Co., Ltd.	58
Dafeng Newti Pharmaceutical Technology Co., Ltd.	55
Taizhou Chuangyuan Industrial Technology Co. Ltd.	58
Shaoxing Fangxiao Chemical Co., LTD	58
Cdreamlab (Hubei) Technology Co., LTD	58
Suzhou Haihe Pharmaceutical Technology Co., Ltd.	58
Chengdu jingzhihuacheng Chemical Technology Co., Ltd.	58
Changzhou Wanyao Biotechnology Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62

View Latest Price from 4-Bromo-1,2-(methylenedioxy)benzene manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-16	4-Bromo-1,2-(methylenedioxy)benzene 2635-13-4			0.99		RongNa Biotechnology Co.,Ltd
2026-03-20	4-Bromo-1,2-(methylenedioxy)benzene 2635-13-4	$1.00	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2022-12-01	5-Bromo-1,3-benzodioxole 2635-13-4	$200.00	10g	99%	1000t/month	Hebei Best Biological Technology Co., Ltd

4-Bromo-1,2-(methylenedioxy)benzene
2635-13-4
0.99
RongNa Biotechnology Co.,Ltd

4-Bromo-1,2-(methylenedioxy)benzene
2635-13-4
$1.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

5-Bromo-1,3-benzodioxole
2635-13-4
$200.00
99%
Hebei Best Biological Technology Co., Ltd

4-Bromo-1,2-(methylenedioxy)benzene Spectrum

4-Bromo-1,2-(methylenedioxy)benzene(2635-13-4)MS 4-Bromo-1,2-(methylenedioxy)benzene(2635-13-4)¹HNMR 4-Bromo-1,2-(methylenedioxy)benzene(2635-13-4)¹³CNMR 4-Bromo-1,2-(methylenedioxy)benzene(2635-13-4)IR1 4-Bromo-1,2-(methylenedioxy)benzene(2635-13-4)Raman

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4-BROMO-1,2-(METHYLENEDIOXY)ENZENE 4-Bromo-1,2-methylenedioxybenzene 99% 5-Bromo-1,3-benzodioxole 99% BROMOBENZODIOXOLE 4-Bromo-1,2-(methylenedioxy)benzene-5 5-Bromo-1,3-benzodioxolane 3,4-Methylenedioxy bromobenzene 1,3-Benzodioxol-5-bromo 4-Bromo-1,2-(methylenedioxy)benzene (Bromobenzodioxole) 4-BROMO-1,2-METHYLENEDIOXYBENZENE 97+% 3,4-Methylenedioxybrombenzene 4-Bromo-1,2-(methylenedioxy)benzene, 5-Bromo-1,3-benzodioxole 1,3-Benzodioxole-5-yl bromide 2-Methylenedioxybenzene 4-BroMo-1,2-(Methylenedioxy)benzene, 97% 25GR 5-Bromo-1,3-benzodioxole 3,4-Methylenedioxybromobenzene 4-BroMo-1,2-(Methylenedixoy) benzene 1-BroMo-3,4-(Methylenedioxy)benzene, 98%+ TIMTEC-BB SBB006662 4-Bromomethylenedioxybenzene 1,3-BENZODIOXOLE, 5-BROMO- 1,2-METHYLENEDIOXY-4-BROMOBENZENE 4-broMo -1,2-(Ya Jiaji twooxygenradicals)benzene 1-BROMO-3,4-(METHYLENEDIOXY)BENZENE 3,4-METHYLENEDIOXYBROMOBENZENE 3,4-METHYLENDIOXYBROMOBENZENE 5-BROMOBENZO-1,3-DIOXOLE 4-Bromo-1,2-(Methylenedioxy)Be 4-Bromo-1,2-methylenedioxybenzene > 4-Bromo-1,2-(methyL enedioxy)benzene 5-bromo-2H-1,3-benzodioxole Paroxetine Impurity 89 4-Bromo pepper ring 1-Bromo-3,4-(methylenedioxy)benzene 97% 4-BROMO-1,2-METHYLENEDIOXYBENZENE 5-BROMO-1,3-BENZODIOXOLE 5-bromobenzo[d][1,3]dioxole 2635-13-4 128577-477-9 Protected Alcohols/Phenols Oxygen Compounds Organic Building Blocks Building Blocks ARYL HALIDE Building Blocks Chemical Synthesis Organic Building Blocks Oxygen Compounds Protected Alcohols/Phenols Miscellaneous Bromine Compounds Miscellaneous Compounds Aromatic Hydrocarbons (substituted) & Derivatives 2635-13-4