1-ACETYL-3-THIOSEMICARBAZIDE
- CAS No.
- 2302-88-7
- Chemical Name:
- 1-ACETYL-3-THIOSEMICARBAZIDE
- Synonyms
- acetamidothiourea;ACETYLTHIOSEMICARBAZIDE;1-ACETYLTHIOSEMICARBAZIDE;1-ACETYL-3-THIOSEMICARBAZIDE;1-Acetylthiosemicarbazide,95%;2-acetylhydrazinecarbothioaMide;N-{[Thio(carbonoimidyl)]amino}acetamide;Acetic acid, 2-(aminothioxomethyl)hydrazide;Acetic acid N'-(aminothioxomethyl) hydrazide
- CBNumber:
- CB5400203
- Molecular Formula:
- C3H7N3OS
- Molecular Weight:
- 133.17
- MDL Number:
- MFCD00004932
- MOL File:
- 2302-88-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| N-{[Thio(carbonoimidyl)]amino}acetamide | TRC-B642518-5G | 5g | $123 |
| N-{[Thio(carbonoimidyl)]amino}acetamide | TRC-B642518-500MG | 500mg | $76 |
| N-{[Thio(carbonoimidyl)]amino}acetamide | TRC-B642518-1G | 1g | $83 |
| 1-Acetyl-3-thiosemicarbazide | FA160492 | 10g | $162.2 |
| 1-Acetyl-3-thiosemicarbazide | FA160492 | 25g | $259.5 |
| Melting point | 165-170 °C |
|---|---|
| Density | 1.280 (estimate) |
| refractive index | 1.7490 (estimate) |
| storage temp. | 2-8°C(protect from light) |
| solubility | DMSO (Sparingly), Methanol (Sparingly) |
| pka | 10.30±0.70(Predicted) |
| form | solid |
| Appearance | Off-white to light yellow Solid |
| Water Solubility | Partly soluble in water. |
| Stability | Hygroscopic |
| CAS DataBase Reference | 2302-88-7(CAS DataBase Reference) |
| FDA UNII | 6EWT2928KE |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312a-P330-P501a |
| Hazard Codes | T |
| Risk Statements | 25-36/37/38 |
| Safety Statements | 24/25-45 |
| RIDADR | 2811 |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29309099 |
| REACH Registrations | Active |
| Limited Quantities | 5.0 kg (11 lbs) (solid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) |
1-ACETYL-3-THIOSEMICARBAZIDE price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-B642518-5G | N-{[Thio(carbonoimidyl)]amino}acetamide | 2302-88-7 | 5g | $123 | 2026-06-03 | Buy |
| TRC | TRC-B642518-500MG | N-{[Thio(carbonoimidyl)]amino}acetamide | 2302-88-7 | 500mg | $76 | 2026-06-03 | Buy |
| TRC | TRC-B642518-1G | N-{[Thio(carbonoimidyl)]amino}acetamide | 2302-88-7 | 1g | $83 | 2026-06-03 | Buy |
| Biosynth | FA160492 | 1-Acetyl-3-thiosemicarbazide | 2302-88-7 | 10g | $162.2 | 2026-06-04 | Buy |
| Biosynth | FA160492 | 1-Acetyl-3-thiosemicarbazide | 2302-88-7 | 25g | $259.5 | 2026-06-04 | Buy |
1-ACETYL-3-THIOSEMICARBAZIDE Chemical Properties,Uses,Production
Chemical Properties
white to slightly beige crystalline powder
Uses
1-Acetyl-3-thiosemicarbazide is applied in pharmaceutical industry as an intermediate.
Synthesis
79-19-6
75-36-5
2302-88-7
General procedure for the synthesis of acetylthiosemicarbazone from aminothiourea and acetyl chloride: preparation of the intermediate 2-acetylcarbazinethioformamide; Acetyl chloride (8.64 g, 0.11 mol) was added slowly and dropwise to an anhydrous tetrahydrofuran (THF, 100 mL) solution of aminothiourea (9.10 g, 0.10 mol) at 0 °C. The reaction mixture was heated to reflux and maintained for 3 hours. Upon completion of the reaction, it was cooled to room temperature and the reaction was quenched by the addition of water (100 mL) followed by extraction with ethyl acetate (3 x 100 mL). The organic phases were combined, washed with saturated saline, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to remove the solvent. The crude product was purified by column chromatography (eluent: methanol/dichloromethane=1/1, v/v) to afford the target compound acetylthiosemicarbazone (8.64 g, 65% yield). The results of mass spectrometry (electrospray ionization, ESI) analysis: m/z calculated value C3H7N3OS [M+H]+ 133.03, measured value 134.0 (MH+).
References
[1] Patent: WO2009/87220, 2009, A1. Location in patent: Page/Page column 57
[2] Yakugaku Zasshi, 1952, vol. 72, p. 376
[3] Chem.Abstr., 1953, p. 3856
[4] Synthetic Communications, 2004, vol. 34, # 22, p. 4189 - 4198
[5] Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2010, vol. 76, # 5, p. 531 - 536
1-ACETYL-3-THIOSEMICARBAZIDE Preparation Products And Raw materials
Raw materials
Preparation Products
1-ACETYL-3-THIOSEMICARBAZIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 | ellena@amitychem.com | China | 43414 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53803 | 58 |
| NANJING YINGWEN BIOTECHNOLOGY CO LTD | +8613382787392 | sales@aeechem.com | China | 10001 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32343 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30123 | 84 |
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