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2-Amino-5-methyl-1,3,4-thiadiazole

2-Amino-5-methyl-1,3,4-thiadiazole structure

CAS No.: 108-33-8

Chemical Name:: 2-Amino-5-methyl-1,3,4-thiadiazole

Synonyms: 5-METHYL-1,3,4-THIADIAZOL-2-AMINE;5-methyl-1,3,4-thiadiazole-2-amine;usafcy-3;TOSLAB 27625;AKOS BBS-00007966;VITAS-BB TBB000116;TIMTEC-BB SBB000045;2-AMINO-5-METHYLTHIADIAZOLE;4-thiadiazol-2-amine,5-methyl-3;4-thiadiazole,2-amino-5-methyl-3

CBNumber:: CB1676271

Molecular Formula:: C3H5N3S

Molecular Weight:: 115.16

MDL Number:: MFCD00003110

MOL File:: 108-33-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 23:43:53

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2-Amino-5-methyl-1,3,4-thiadiazole Properties

Melting point	223-228 °C
Boiling point	261.2±23.0 °C(Predicted)
Density	1.287 (estimate)
refractive index	1.5800 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO (Sparingly), Methanol (Slightly)
form	solid
pka	3.84±0.10(Predicted)
color	Off-White
InChI	InChI=1S/C3H5N3S/c1-2-5-6-3(4)7-2/h1H3,(H2,4,6)
InChIKey	HMPUHXCGUHDVBI-UHFFFAOYSA-N
SMILES	S1C(C)=NN=C1N
CAS DataBase Reference	108-33-8(CAS DataBase Reference)
FDA UNII	NC799929EM
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P264-P270-P301+P312-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

24/25-37/39-26

WGK Germany

RTECS

XI3500000

Hazard Note

Irritant

HS Code

29349990

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
1		0

2-Amino-5-methyl-1,3,4-thiadiazole price More Price(62)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	686166	2-Amino-5-methyl-1,3,4-thiadiazole 97%	108-33-8	5g	$67.4	2026-04-30	Buy
TCI Chemical	A0874	2-Amino-5-methyl-1,3,4-thiadiazole >98.0%(T)	108-33-8	5g	$30	2026-04-30	Buy
TCI Chemical	A0874	2-Amino-5-methyl-1,3,4-thiadiazole >98.0%(T)	108-33-8	25g	$97	2026-04-30	Buy
TRC	TRC-A617080-5G	2-Amino-5-methyl-1,3,4-thiadiazole	108-33-8	5g	$109	2026-06-03	Buy
TRC	TRC-A617080-25G	2-Amino-5-methyl-1,3,4-thiadiazole	108-33-8	25g	$246	2026-06-03	Buy

Product number	Packaging	Price	Buy
686166	5g	$67.4	Buy
A0874	5g	$30	Buy
A0874	25g	$97	Buy
TRC-A617080-5G	5g	$109	Buy
TRC-A617080-25G	25g	$246	Buy

2-Amino-5-methyl-1,3,4-thiadiazole Chemical Properties,Uses,Production

Chemical Properties

White to light beige crystalline powder

Uses

2-Amino-5-methyl-1,3,4-thiadiazole was used as a reagent in the synthesis of substituted 5H-benzo[i][1,3,4]thiadiazolo[3,2-a]quinazoline-6,7-diones which diplayed good cytotoxic activities. Also used in the design of new phenothiazine-thiadiazole hybrids for development of antitubercular agents.

Definition

ChEBI: 5-Methyl-1,3,4-thiadiazol-2-amine is a member of thiadiazoles.

Synthesis

64-19-7

79-19-6

108-33-8

1) 0.05 mol of aminothiourea was added to a dry mortar, followed by 0.055 mol of glacial acetic acid, 0.055 mol of silica, and 0.25 mol of phosphorus trichloride, and ground for 10 min at room temperature. The progress of the reaction was monitored by thin layer chromatography (TLC) using a solvent mixture of ethyl acetate and petroleum ether in the ratio of 1:3 by volume as the unfolding agent until the point of raw material aminothiourea disappeared, indicating that the reaction was complete. The crude product was obtained after standing for 30 min.2) The crude product was transferred to a beaker and the pH was adjusted to 8 by adding 5% sodium carbonate solution.The mixture was withdrawn and filtered and the filter cake was dissolved with N,N-dimethylformamide (DMF) to remove silica gel. The filtrate was concentrated under reduced pressure, and after removing the solvent, washed with water and filtered by suction to afford 2-amino-5-methyl-1,3,4-thiadiazole in 95.2% yield.

References

[1] Patent: CN103880776, 2016, B. Location in patent: Paragraph 0024-0026
[2] Bulletin of the Chemical Society of Japan, 1982, vol. 55, # 2, p. 637 - 638
[3] Synthetic Communications, 2000, vol. 30, # 16, p. 3031 - 3040
[4] Journal of the Chemical Society of Pakistan, 2015, vol. 37, # 1, p. 115 - 121
[5] Journal of Chemical Research, 2005, # 5, p. 341 - 343

2-Amino-5-methyl-1,3,4-thiadiazole synthesis

Synthesis of 2-Amino-5-methyl-1,3,4-thiadiazole from Acetic acid and Thiosemicarbazide

2-Amino-5-methyl-1,3,4-thiadiazole Preparation Products And Raw materials

Raw materials

4,5-Dihydro-2,3,4,4-tetramethyloxazolium iodide 2,3-Dimethylthiazolinium iodide Acetamide,N-(5-methyl-1,3,4-thiadiazol-2-yl)- Benzyl thioacetimidate hydrochloride 3-methyl-1H-1,2,4-triazole-5-thiol

Acetaldehyde Trimethylsilyl isothiocyanate 1-Acetyl-3-thiosemicarbazide (1E)-3-amino-1-ethylidene-thiourea Thiosemicarbazide

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Preparation Products

1,3,4-Thiadiazole,2-methyl-5-nitro-(8CI,9CI) N-(5-Methyl-1,3,4-thiadiazol-2-yl)-4-nitrobenzamide

2-Amino-5-methyl-1,3,4-thiadiazole Suppliers

Global( 302)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Xi'an Yutebang New Material Technology Co., Ltd.	029-84536388 19991842844	ella@yutbon.com	China	155	58
Quzhou HuntBio Co., Ltd.	0571-64067827 13372408495	sales@huntchem.com	China	75	60
Weizongchen Pharmaceutical Service (Shanghai) Limited	021 6089 3288 18163855446	co@viva-supply.com	China	35	58
Creasyn Finechem(Tianjin) Co., Ltd.	022-83946278 13820372920	sales@creasyn.com	China	968	68
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61

Supplier	Advantage
Xi'an Yutebang New Material Technology Co., Ltd.	58
Quzhou HuntBio Co., Ltd.	60
Weizongchen Pharmaceutical Service (Shanghai) Limited	58
Creasyn Finechem(Tianjin) Co., Ltd.	68
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
INTATRADE GmbH	66
Chembest Research Laboratories Limited	61
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61

View Lastest Price from 2-Amino-5-methyl-1,3,4-thiadiazole manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	2-Amino-5-methyl-1,3,4-thiadiazole 108-33-8	$6.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2025-04-04	2-Amino-5-methyl-1,3,4-thiadiazole 108-33-8		1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.
2019-07-06	2-Amino-5-methyl-1,3,4-thiadiazole 108-33-8	$8.00	1kg	99%	10MT	Career Henan Chemical Co

2-Amino-5-methyl-1,3,4-thiadiazole
108-33-8
$6.00
99%
Henan Fengda Chemical Co., Ltd

2-Amino-5-methyl-1,3,4-thiadiazole
108-33-8
98%
Henan Aochuang Chemical Co.,Ltd.

2-Amino-5-methyl-1,3,4-thiadiazole
108-33-8
$8.00
99%
Career Henan Chemical Co

2-Amino-5-methyl-1,3,4-thiadiazole Spectrum

2-Amino-5-methyl-1,3,4-thiadiazole(108-33-8)MS 2-Amino-5-methyl-1,3,4-thiadiazole(108-33-8)¹HNMR 2-Amino-5-methyl-1,3,4-thiadiazole(108-33-8)¹³CNMR 2-Amino-5-methyl-1,3,4-thiadiazole(108-33-8)IR1 2-Amino-5-methyl-1,3,4-thiadiazole(108-33-8)IR2

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TIMTEC-BB SBB000045 VITAS-BB TBB000116 TOSLAB 27625 4-thiadiazol-2-amine,5-methyl-3 4-thiadiazole,2-amino-5-methyl-3 usafcy-3 1,3,4-Thiadiazole, 2-amino-5-methyl. 5-methyl-2-amino-1,3,4-thiadiazole 2-AMINO-5-METHYL-1,3,4-THIADIAZOLE 97% 2-AMINO-5-METHYL-1,3,4-THIADIZOLE 5-METHYL-[1,3,4]THIADIAZOL-2-YLAMINE AKOS BBS-00007966 2-AMINO-5-METHYL-1,3,4-THIADIAZOLE 2-AMINO-5-METHYLTHIADIAZOLE 2-AMino-5-Methyl-1,3,4-thiadiazole, 97% 5GR 1,3,4-Thiadiazol-2-amine, 5-methyl 2-Amino-5-methyl-1,3,4-thiadiazole,97% 2-Amino-5-methyl-1,3,4-thiadiazole > 2-Amino-5-jnethyl-l, 3, 4-thiadi azole 5-methyl-1,3,4-thiadiazole-2-amine 5-METHYL-1,3,4-THIADIAZOL-2-AMINE 108-33-8 1456-57-9 Amines Oxadiazoles & Thiadiazoles API intermediates Oxadiazoles & Thiadiazoles Building Blocks Heterocyclic Building Blocks Thiadiazoles