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2-Amino-5-methyl-1,3,4-thiadiazole

2-Amino-5-methyl-1,3,4-thiadiazole Structure
2-Amino-5-methyl-1,3,4-thiadiazole structure
CAS No.
108-33-8
Chemical Name:
2-Amino-5-methyl-1,3,4-thiadiazole
Synonyms
5-METHYL-1,3,4-THIADIAZOL-2-AMINE;5-methyl-1,3,4-thiadiazole-2-amine;usafcy-3;TOSLAB 27625;AKOS BBS-00007966;VITAS-BB TBB000116;TIMTEC-BB SBB000045;2-AMINO-5-METHYLTHIADIAZOLE;4-thiadiazol-2-amine,5-methyl-3;4-thiadiazole,2-amino-5-methyl-3
CBNumber:
CB1676271
Molecular Formula:
C3H5N3S
Molecular Weight:
115.16
MDL Number:
MFCD00003110
MOL File:
108-33-8.mol
MSDS File:
SDS
Last updated:2026-01-13 11:14:19
Product description Number Pack Size Price
2-Amino-5-methyl-1,3,4-thiadiazole 97% 686166 5g $44.31
2-Amino-5-methyl-1,3,4-thiadiazole >98.0%(T) A0874 5g $52
2-Amino-5-methyl-1,3,4-thiadiazole >98.0%(T) A0874 25g $169
2-Amino-5-methyl-1,3,4-thiadiazole A617080 50g $325
2-Amino-5-methyl-1,3,4-thiadiazole FA34351 250g $500
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2-Amino-5-methyl-1,3,4-thiadiazole Properties

Melting point 223-228 °C
Boiling point 261.2±23.0 °C(Predicted)
Density 1.287 (estimate)
refractive index 1.5800 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Sparingly), Methanol (Slightly)
pka 3.84±0.10(Predicted)
form solid
color Off-White
InChI InChI=1S/C3H5N3S/c1-2-5-6-3(4)7-2/h1H3,(H2,4,6)
InChIKey HMPUHXCGUHDVBI-UHFFFAOYSA-N
SMILES S1C(C)=NN=C1N
CAS DataBase Reference 108-33-8(CAS DataBase Reference)
FDA UNII NC799929EM
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  24/25-37/39-26
WGK Germany  3
RTECS  XI3500000
Hazard Note  Irritant
HS Code  29349990
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
0
1 0

2-Amino-5-methyl-1,3,4-thiadiazole price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 686166 2-Amino-5-methyl-1,3,4-thiadiazole 97% 108-33-8 5g $44.31 2025-07-31 Buy
TCI Chemical A0874 2-Amino-5-methyl-1,3,4-thiadiazole >98.0%(T) 108-33-8 5g $52 2025-07-31 Buy
TCI Chemical A0874 2-Amino-5-methyl-1,3,4-thiadiazole >98.0%(T) 108-33-8 25g $169 2025-07-31 Buy
TRC A617080 2-Amino-5-methyl-1,3,4-thiadiazole 108-33-8 50g $325 2021-12-16 Buy
Biosynth Carbosynth FA34351 2-Amino-5-methyl-1,3,4-thiadiazole 108-33-8 250g $500 2021-12-16 Buy
Product number Packaging Price Buy
686166 5g $44.31 Buy
A0874 5g $52 Buy
A0874 25g $169 Buy
A617080 50g $325 Buy
FA34351 250g $500 Buy

2-Amino-5-methyl-1,3,4-thiadiazole Chemical Properties,Uses,Production

Chemical Properties

White to light beige crystalline powder

Uses

2-Amino-5-methyl-1,3,4-thiadiazole was used as a reagent in the synthesis of substituted 5H-benzo[i][1,3,4]thiadiazolo[3,2-a]quinazoline-6,7-diones which diplayed good cytotoxic activities. Also used in the design of new phenothiazine-thiadiazole hybrids for development of antitubercular agents.

Definition

ChEBI: 5-Methyl-1,3,4-thiadiazol-2-amine is a member of thiadiazoles.

Synthesis

Acetic acid

64-19-7

thiosemicarbazide

79-19-6

2-Amino-5-methyl-1,3,4-thiadiazole

108-33-8

1) 0.05 mol of aminothiourea was added to a dry mortar, followed by 0.055 mol of glacial acetic acid, 0.055 mol of silica, and 0.25 mol of phosphorus trichloride, and ground for 10 min at room temperature. The progress of the reaction was monitored by thin layer chromatography (TLC) using a solvent mixture of ethyl acetate and petroleum ether in the ratio of 1:3 by volume as the unfolding agent until the point of raw material aminothiourea disappeared, indicating that the reaction was complete. The crude product was obtained after standing for 30 min.2) The crude product was transferred to a beaker and the pH was adjusted to 8 by adding 5% sodium carbonate solution.The mixture was withdrawn and filtered and the filter cake was dissolved with N,N-dimethylformamide (DMF) to remove silica gel. The filtrate was concentrated under reduced pressure, and after removing the solvent, washed with water and filtered by suction to afford 2-amino-5-methyl-1,3,4-thiadiazole in 95.2% yield.

References

[1] Patent: CN103880776, 2016, B. Location in patent: Paragraph 0024-0026
[2] Bulletin of the Chemical Society of Japan, 1982, vol. 55, # 2, p. 637 - 638
[3] Synthetic Communications, 2000, vol. 30, # 16, p. 3031 - 3040
[4] Journal of the Chemical Society of Pakistan, 2015, vol. 37, # 1, p. 115 - 121
[5] Journal of Chemical Research, 2005, # 5, p. 341 - 343

2-Amino-5-methyl-1,3,4-thiadiazole synthesis

64-19-7
79-19-6
108-33-8
Synthesis of 2-Amino-5-methyl-1,3,4-thiadiazole from Acetic acid and thiosemicarbazide

2-Amino-5-methyl-1,3,4-thiadiazole Preparation Products And Raw materials

Raw materials

4,5-Dihydro-2,3,4,4-tetramethyloxazolium iodide 2,3-DIMETHYLTHIAZOLINIUM IODIDE Acetamide,N-(5-methyl-1,3,4-thiadiazol-2-yl)- BENZYL THIOACETIMIDATE HYDROCHLORIDE 3-methyl-1H-1,2,4-triazole-5-thiol
Acetaldehyde TRIMETHYLSILYL ISOTHIOCYANATE 1-ACETYL-3-THIOSEMICARBAZIDE (1E)-3-amino-1-ethylidene-thiourea thiosemicarbazide

1of2

Preparation Products

1,3,4-Thiadiazole,2-methyl-5-nitro-(8CI,9CI) N-(5-METHYL-1,3,4-THIADIAZOL-2-YL)-4-NITROBENZAMIDE

2-Amino-5-methyl-1,3,4-thiadiazole Suppliers

Global( 290)Suppliers
Supplier Tel Email Country ProdList Advantage
Xi'an Yutbon Pharmaceutical Technology Co., Ltd
029-81140587 +8618717328141 sales@yutbon.com China 454 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20128 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21597 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29831 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10821 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
Supplier Advantage
Xi'an Yutbon Pharmaceutical Technology Co., Ltd
58
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Accela ChemBio Inc. 		58
Alchem Pharmtech,Inc. 		58
Wuhan Chemwish Technology Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
SIMAGCHEM CORP 		58

View Lastest Price from 2-Amino-5-methyl-1,3,4-thiadiazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Amino-5-methyl-1,3,4-thiadiazole pictures 2025-09-25 2-Amino-5-methyl-1,3,4-thiadiazole
108-33-8
 US $6.00-0.90 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
2-Amino-5-methyl-1,3,4-thiadiazole pictures 2025-04-04 2-Amino-5-methyl-1,3,4-thiadiazole
108-33-8
 US $0.00-0.00 / KG 1KG 98% 1ton Henan Aochuang Chemical Co.,Ltd.
2-Amino-5-methyl-1,3,4-thiadiazole pictures 2019-07-06 2-Amino-5-methyl-1,3,4-thiadiazole
108-33-8
 US $8.00 / kg 1kg 99% 10MT Career Henan Chemical Co

2-Amino-5-methyl-1,3,4-thiadiazole Spectrum

2-Amino-5-methyl-1,3,4-thiadiazole(108-33-8)MS2-Amino-5-methyl-1,3,4-thiadiazole(108-33-8)1HNMR2-Amino-5-methyl-1,3,4-thiadiazole(108-33-8)13CNMR2-Amino-5-methyl-1,3,4-thiadiazole(108-33-8)IR12-Amino-5-methyl-1,3,4-thiadiazole(108-33-8)IR2

108-33-8(2-Amino-5-methyl-1,3,4-thiadiazole)Related Search:

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Pirimiphos-methyl METSULFURON METHYL N,N-Dimethyl-1,4-phenylenediamine Thiophanate-methyl Tris(hydroxymethyl)aminomethane
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TIMTEC-BB SBB000045 VITAS-BB TBB000116 TOSLAB 27625 4-thiadiazol-2-amine,5-methyl-3 4-thiadiazole,2-amino-5-methyl-3 5-methyl-1,3,4-thiadiazole-2-amine usafcy-3 1,3,4-Thiadiazole, 2-amino-5-methyl. 5-methyl-2-amino-1,3,4-thiadiazole 2-AMINO-5-METHYL-1,3,4-THIADIAZOLE 97% 2-AMINO-5-METHYL-1,3,4-THIADIZOLE 5-METHYL-1,3,4-THIADIAZOL-2-AMINE 5-METHYL-[1,3,4]THIADIAZOL-2-YLAMINE AKOS BBS-00007966 2-AMINO-5-METHYL-1,3,4-THIADIAZOLE 2-AMINO-5-METHYLTHIADIAZOLE 2-AMino-5-Methyl-1,3,4-thiadiazole, 97% 5GR 1,3,4-Thiadiazol-2-amine, 5-methyl 2-Amino-5-methyl-1,3,4-thiadiazole,97% 2-Amino-5-methyl-1,3,4-thiadiazole > 2-Amino-5-jnethyl-l, 3, 4-thiadi azole 108-33-8 1456-57-9 Amines Oxadiazoles & Thiadiazoles API intermediates Oxadiazoles & Thiadiazoles Building Blocks Heterocyclic Building Blocks Thiadiazoles