Hydroflumethiazide
- CAS No.
- 135-09-1
- Chemical Name:
- Hydroflumethiazide
- Synonyms
- hydol;River;naclex;Ademil;rontyl;elodrin;finuret;bristab;saluron;sisuril
- CBNumber:
- CB5416596
- Molecular Formula:
- C8H8F3N3O4S2
- Molecular Weight:
- 331.29
- MDL Number:
- MFCD00057316
- MOL File:
- 135-09-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 272-273 |
|---|---|
| Boiling point | 531.6±60.0 °C(Predicted) |
| Density | 1.5955 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | DMSO (Slightly), Methanol (Sparingly) |
| form | Solid |
| pka | 8.9, 8.2(at 25℃) |
| color | White |
| Water Solubility | 329.9mg/L(room temperature) |
| Major Application |
pharmaceutical pharmaceutical small molecule |
| InChI | 1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16) |
| InChIKey | DMDGGSIALPNSEE-UHFFFAOYSA-N |
| SMILES | O=S1(C2=CC(S(=O)(N)=O)=C(C(F)(F)F)C=C2NCN1)=O |
| EWG's Food Scores | 1 |
| FDA UNII | 501CFL162R |
| ATC code | C03AA02,C03AH02 |
| EPA Substance Registry System | 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide (135-09-1) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H317-H334 | |||||||||
| Precautionary statements | P261-P280-P284-P304+P340-P342+P311 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 42/43 | |||||||||
| Safety Statements | 36 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | DK9625000 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2935904000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Resp. Sens. 1 Skin Sens. 1 |
|||||||||
| Hazardous Substances Data | 135-09-1(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 in mice (mg/kg): >8000 orally, 750 i.v., 6280 i.p. (Piala) | |||||||||
| NFPA 704 |
|
Hydroflumethiazide price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | BP190 | Hydroflumethiazide British Pharmacopoeia (BP) Reference Standard | 135-09-1 | 100MG | $292 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1322007 | Hydroflumethiazide United States Pharmacopeia (USP) Reference Standard | 135-09-1 | 200mg | $502 | 2026-04-30 | Buy |
| Cayman Chemical | 23612 | Hydroflumethiazide ≥98% | 135-09-1 | 50mg | $134 | 2026-04-30 | Buy |
| Cayman Chemical | 23612 | Hydroflumethiazide ≥98% | 135-09-1 | 100mg | $213 | 2026-04-30 | Buy |
| Usbiological | 013289 | Hydroflumethiazide ~95% | 135-09-1 | 100mg | $439 | 2026-06-03 | Buy |
Hydroflumethiazide Chemical Properties, Uses, Production
Chemical Properties
White Solid
Originator
Saluron,Bristol,US,1959
Uses
Labelled Hydroflumethiazide. Antihypertensive; diuretic.
Definition
ChEBI: Hydroflumethiazide is a benzothiadiazine consisting of a 3,4-dihydro-HH-1,2,4-benzothiadiazine bicyclic system dioxygenated on sulfur and carrying trifluoromethyl and aminosulfonyl groups at positions 6 and 7 respectively. A diuretic with actions and uses similar to those of hydrochlorothiazide. It has a role as a diuretic and an antihypertensive agent. It is a benzothiadiazine and a thiazide.
Manufacturing Process
(a) Preparation of 5-Trifluoromethylaniline-2,4-Disulfonyl Chloride: 113 ml of
chlorosulfonic acid was cooled in an ice-bath, and to the acid was added
dropwise while stirring 26.6 grams of α,α,α-trifluoro-m-toluidine. 105 grams of
sodium chloride was added during 1 to 2 hours, whereafter the temperature
of the reaction mixture was raised slowly to 150° to 160°C, which
temperature was maintained for 3 hours. After cooling the mixture, ice-cooled
water was added, whereby 5-trifluoromethylaniline-2,4-disulfonyl chloride
separated out from the mixture.
(b) Preparation of 5-Trifluoromethyl-2,4-Disulfamylaniline: The 5-
trifluoromethylaniline-2,4-disulfonyl chloride obtained in step (a) was taken up
in ether and the ether solution dried with magnesium sulfate. The ether was
removed from the solution by distillation, the residue was cooled to 0°C and
60 ml of ice-cooled, concentrated ammonia water was added while stirring.
The solution was then heated for one hour on a steam bath and evaporated in
vacuo to crystallization. The crystallized product was 5-trifluoromethyl-2,4-
disulfamylaniline, which was filtered off, washed with water and dried in a
vacuum exsiccator over phosphorus pentoxide. After recrystallization from a
mixture of 30% ethanol and 70% water the compound had a MP of 247° to
248°C.
(e) Preparation of 6-Trifluoromethyl-7-Sulfamyl-3,4-Dihydro-1,2,4-
Benzothiadiazine-1,1-Dioxide: 3.2 grams of 5-trifluoromethyl-2,4-
disulfamylaniline was added to a solution of 0.33 gram of paraformaldehyde in
25 ml of methyl Cellosolve (2-methoxy ethanol) together with a catalytic
amount of p-toluenesulfonic acid, and the mixture was boiled with reflux for 5
hours. The solvent was then distilled off in vacuo, and the residue triturated
with 30 ml of ethyl acetate. 6-trifluoromethyl-7-sulfamyl-3,4-dihydro-1,2,4-
benzothiadiazine-1,1-dioxide crystallized out. After recrystallization from methanol/water the substance had a MP of 272° to 273°C.
Therapeutic Function
Diuretic, Antihypertensive
Hydroflumethiazide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9791 | 79 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8039 | 58 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15775 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Changzhou Hopschain Chemical Co.,Ltd. | 85528066 13775048983 | sales@hopschem.com | China | 31548 | 55 |
View Latest Price from Hydroflumethiazide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | HYDROFLUMETHIAZIDE USP/EP/BP
135-09-1
|
$1.10 | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-05-26 | Hydroflumethiazide
135-09-1
|
10g | TargetMol Chemicals Inc. |
-
- HYDROFLUMETHIAZIDE USP/EP/BP
135-09-1
- $1.10
- 99.9%
- Dideu Industries Group Limited
-
- Hydroflumethiazide
135-09-1
- $0.00
- TargetMol Chemicals Inc.
135-09-1 (Hydroflumethiazide) Related Search:
1of3
