Urolithin B
- CAS No.
- 1139-83-9
- Chemical Name:
- Urolithin B
- Synonyms
- Urolithin B;Uro-B;NeolithicB;AURORA 226;Urolithinum;Uricosuric B;3-Hydroxy-6H<;AKOS BBS-00008028;3-hydroxy urolithin;Urolithin B, 10 mM in DMSO
- CBNumber:
- CB5467477
- Molecular Formula:
- C13H8O3
- Molecular Weight:
- 212.2
- MDL Number:
- MFCD00034338
- MOL File:
- 1139-83-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 247 °C |
|---|---|
| Boiling point | 432.6±24.0 °C(Predicted) |
| Density | 1.395±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble5mg/mL, clear (warmed) |
| pka | 9.03±0.20(Predicted) |
| form | powder |
| color | white to beige |
| Stability | Hygroscopic |
| InChI | InChI=1S/C13H8O3/c14-8-5-6-10-9-3-1-2-4-11(9)13(15)16-12(10)7-8/h1-7,14H |
| InChIKey | WXUQMTRHPNOXBV-UHFFFAOYSA-N |
| SMILES | C12=CC(O)=CC=C1C1=CC=CC=C1C(=O)O2 |
| LogP | 2.947 (est) |
| FDA UNII | B1S2YM5F6G |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319 | |||||||||
| Precautionary statements | P301+P312+P330-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2932209090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 |
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| NFPA 704 |
|
Urolithin B price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1649 | Urolithin B ≥95% (HPLC) | 1139-83-9 | 10mg | $119 | 2026-04-30 | Buy |
| Sigma-Aldrich | OTV000001 | 3-Hydroxy-6H-benzo[c]chromen-6-one AldrichCPR | 1139-83-9 | 250mg | $41.5 | 2024-03-01 | Buy |
| Cayman Chemical | 33757 | Urolithin B ≥98% | 1139-83-9 | 500mg | $103 | 2026-04-30 | Buy |
| Cayman Chemical | 33757 | Urolithin B ≥98% | 1139-83-9 | 1g | $194 | 2026-04-30 | Buy |
| Cayman Chemical | 33757 | Urolithin B ≥98% | 1139-83-9 | 5g | $753 | 2026-04-30 | Buy |
Urolithin B Chemical Properties,Uses,Production
Uses
Urolithin B is an intestinal microbial metabolite of ellagitannis and exhibits potent anti-oxidant and pro-oxidant activies depending on the assay system and conditions. Urolithin B can also display estrogenic and/or anti-estrogenic activity.
Definition
ChEBI: Urolithin B is a member of coumarins.
Biochem/physiol Actions
Urolithin B is a natural product with antiproliferative and antioxidant activity. Urolithin B is formed by metabolism from polyphenols found in some nuts and fruits, particularly pomegranates. Urolithin B has been shown to cross the blood brain barrier, and may have neuroprotective effects against Alzheimer′s Disease.
Synthesis
![3-methoxy-6H-benzo[c]chromen-6-one](/CAS/20180808/GIF/1143-62-0.gif)
1143-62-0
1139-83-9
GENERAL METHODS: Urolithin A-C (30a-c, 1.0 eq.) was dissolved in methyl ether and cooled to 0 °C under argon protection. Boron tribromide (BBr3) was slowly added and the reaction progress was monitored by thin layer chromatography (TLC) until the starting material was completely consumed. Subsequently, the reaction mixture was acidified by the addition of 2N hydrochloric acid solution and extracted with ethyl acetate (EtOAc) to obtain the crude product. Finally, the crude product was purified by size exclusion chromatography to obtain the target compound 3-hydroxy-6H-benzo[c]benzopyran-6-one.
in vivo
Urolithin B (50 mg/kg; ip; once daily for 4 days) inhibits microglial activation in LPS-injected mouse brains, under neuroinflammatory condition[1].
Urolithin B (10 μg/day; mini-osmotic pump delivery, 28 days) induces muscle hypertrophy and reduces muscle atrophy after sciatic nerve transection in mice[2].
IC 50
Human Endogenous Metabolite
References
[1] Tetrahedron, 2013, vol. 69, # 44, p. 9277 - 9283
[2] European Journal of Medicinal Chemistry, 2019, vol. 161, p. 433 - 444
[3] Journal of Organic Chemistry, 2017, vol. 82, # 10, p. 5080 - 5095
[4] ChemMedChem, 2010, vol. 5, # 9, p. 1616 - 1630
Urolithin B Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Urolithin B Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| JinanGongchuang Pharmaceutical Technology Co. Ltd.. | 88065293 13287783460 | 3166282224@qq.com | China | 40 | 58 |
| Smartchem(Beijing) Ltd. | 010-57203829 | 15810312480@139.com | China | 50 | 55 |
| Suzhou Lyran Biopharma And Technology CO.,LTD. | 15556287180 15556287180 | 1184800090@qq.com | China | 408 | 58 |
| Wudi Rongchuan Pharmaceutical and Chemical Technology Co., Ltd. | 021-5147-3705 17852115892 | wxj@yananpharm.com | China | 64 | 58 |
| Shan Dong FengJin Pharmaceutical Co.,Ltd. | 18364437686 18364437686 | 15066764791@163.com | China | 33 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Wuhan Vanzpharm Inc. | 027-84492310 | 1009@qq.com | China | 41 | 58 |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3993 | 55 |
| Wuhan Kaymke Chemical Co., Ltd., | 027-87342388 18086026008 | sales@kaymke.com | China | 3544 | 55 |
View Lastest Price from Urolithin B manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | Urolithin B
1139-83-9
|
1kg | 99% | 3000kg | Jinan Jianfeng Chemical Co., Ltd | ||
 |
2026-09-11 | Urolithin B
1139-83-9
|
$2.50 | 1kg | 99.45 | 60 tons | Jinan Million Pharmaceutical Co., Ltd | |
 |
2026-09-07 | Urolithin B
1139-83-9
|
1kg | 0.99 | 2000KGS | HANGZHOU HAILAN CHEMICAL CO.,LTD. |
-
- Urolithin B
1139-83-9
- 99%
- Jinan Jianfeng Chemical Co., Ltd
-
- Urolithin B
1139-83-9
- $2.50
- 99.45
- Jinan Million Pharmaceutical Co., Ltd
-
- Urolithin B
1139-83-9
- $0.00
- 0.99
- HANGZHOU HAILAN CHEMICAL CO.,LTD.
