GR 82334
- CAS No.
- 129623-01-4
- Chemical Name:
- GR 82334
- Synonyms
- GR 82334;pglu-ala-asp-pro-asn-lys-phe-tyr-pro(spiro-γ-lactam-leu-trp-nh2;[[(S,S)PRO-LEU(SPIRO-GAMMA-LACTAM)]9,10, TRP11]PHYSALAEMIN (1-11);PGLU-ALA-ASP-PRO-ASN-LYS-PHE-TYR-PRO(SPIRO-GAMMA-LACTAM)-LEU-TRP-NH2;L-Tryptophanamide, 5-oxo-L-prolyl-L-alanyl-L-α-aspartyl-L-prolyl-L-asparaginyl-L-lysyl-L-phenylalanyl-L-tyrosyl-(αS,5S)-α-(2-methylpropyl)-6-oxo-1,7-diazaspiro[4.4]nonane-7-acetyl-
- CBNumber:
- CB5476231
- Molecular Formula:
- C69H91N15O16
- Molecular Weight:
- 1386.55
- MDL Number:
- MFCD00214619
- MOL File:
- 129623-01-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| GR 82334 | EFA62301 | 1mg | $1112.03 |
| GR 82334 | EFA62301 | 5mg | $3142.7 |
| GR 82334 | EFA62301 | 10mg | $5028.3 |
| GR 82334 | EFA62301 | 25mg | $9428 |
| GR 82334 | EFA62301 | 50mg | $15085 |
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 |
|---|---|
| WGK Germany | 3 |
GR 82334 price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | EFA62301 | GR 82334 | 129623-01-4 | 1mg | $1112.03 | 2026-06-04 | Buy |
| Biosynth | EFA62301 | GR 82334 | 129623-01-4 | 5mg | $3142.7 | 2026-06-04 | Buy |
| Biosynth | EFA62301 | GR 82334 | 129623-01-4 | 10mg | $5028.3 | 2026-06-04 | Buy |
| Biosynth | EFA62301 | GR 82334 | 129623-01-4 | 25mg | $9428 | 2026-06-04 | Buy |
| Biosynth | EFA62301 | GR 82334 | 129623-01-4 | 50mg | $15085 | 2026-06-04 | Buy |
GR 82334 Chemical Properties,Uses,Production
Uses
GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist[1]. GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats[1].
in vivo
GR 82334 (intrathecal administration; 0.1 nmol-1 nmol) excites rats unnary bladder motihty at 1 nmol but not at 0.1 nmol, and the reflex chemonociceptive is reduced by the topical application of capsaicin (4 μg/50 ul)[1].GR 82334 (10 nM-1 μM; injected between vertebrae L4 and L5) has no effect at 10 nM in neither species, increases heat-induced foot withdrawal latency in mice at doses >100 nM, but no such increase in naked mole-rats, where doses >100 nM evoke a tendency for decreased latency[2].
| Animal Model: | 3-6 month-old, male C57BL/6 mice and 6-18 month-old naked mole-rats[2] |
| Dosage: | 10 nM, 100 nM, and 1 μM |
| Administration: | Lntrathecal injection between vertebrae L4 and L5 |
| Result: | Increased heat-induced foot withdrawal latency in mice. |
References
[1] A Lecci,et al.Effect of the NK-1 receptor antagonist GR 82,334 on reflexly-induced bladder contractions. Life Sci DOI:10.1016/0024-3205(92)90165-l
[2] Antje Brand, et al. Functional neurokinin and NMDA receptor activity in an animal naturally lacking substance P: the naked mole-rat.PLoS One. 2010 Dec 21;5(12):e15162. DOI:10.1371/journal.pone.0015162
GR 82334 Preparation Products And Raw materials
Raw materials
Preparation Products
GR 82334 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7858 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Hangzhou Sinoda Pharmaceutical Technology Co. LTD | 0571-87213919 17306812703 | 3007955328@qq.com | China | 7431 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5987 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 58 |
| BOC Sciences | 65 |
| Hangzhou Sinoda Pharmaceutical Technology Co. LTD | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 58 |
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