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(3S)-(-)-3-(Dimethylamino)pyrrolidine

(3S)-(-)-3-(Dimethylamino)pyrrolidine structure

CAS No.: 132883-44-4

Chemical Name:: (3S)-(-)-3-(Dimethylamino)pyrrolidine

Synonyms: (S)-N,N-dimethylpyrrolidin-3-amine;(3S)-N;**DISCONTINUED** Alt H30661;(3S)-3-DIMETHYLAMINOPYRROLIDINE;(S)-3-(DIMETHYLAMINO) PYRROLIDINE;S- N,N-diMethyl-3-PyrrolidinaMine;DIMETHYL-PYRROLIDIN-3-YL-AMINE (S);(S)-DIMETHYL-PYRROLIDIN-3-YL-AMINE;(3S)-N,N-DIMETHYL-3-PYRROLIDINAMINE;(3S)-DIMETHYL-PYRROLIDIN-3-YL-AMINE

CBNumber:: CB4147462

Molecular Formula:: C6H14N2

Molecular Weight:: 114.19

MDL Number:: MFCD00191348

MOL File:: 132883-44-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:52:22

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(3S)-(-)-3-(Dimethylamino)pyrrolidine Properties

Boiling point	160 °C/760 mmHg (lit.)
Density	0.899 g/mL at 25 °C (lit.)
refractive index	n20/D 1.4650(lit.)
Flash point	125 °F
storage temp.	2-8°C
pka	9.93±0.10(Predicted)
form	clear liquid
color	Colorless to Light yellow
Specific Gravity	0.90
optical activity	[α]/D 14±2°, c = 1 in ethanol
InChI	InChI=1S/C6H14N2/c1-8(2)6-3-4-7-5-6/h6-7H,3-5H2,1-2H3/t6-/m0/s1
InChIKey	AVAWMINJNRAQFS-LURJTMIESA-N
SMILES	N1CC[C@H](N(C)C)C1
CAS DataBase Reference	132883-44-4(CAS DataBase Reference)
UNSPSC Code	12352005
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS05,GHS07

Signal word

Danger

Hazard statements

H226-H302-H315-H318-H335

Precautionary statements

P210-P233-P280-P301+P312-P303+P361+P353-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

10-22-37/38-41-38-37

Safety Statements

26-39

RIDADR

UN 1993 3/PG 3

WGK Germany

HazardClass

PackingGroup

III

HS Code

2933998090

Storage Class

3 - Flammable liquids

Hazard Classifications

Acute Tox. 4 Oral
Eye Dam. 1
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3

Limited Quantities

5.0 L (1.3 gallons) (liquid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	2
3		0

(3S)-(-)-3-(Dimethylamino)pyrrolidine price More Price(49)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	656704	(S)-(?)-3-(Dimethylamino)pyrrolidine 97%	132883-44-4	1g	$109	2023-06-20	Buy
TCI Chemical	D2193	(3S)-(-)-3-(Dimethylamino)pyrrolidine >98.0%(GC)	132883-44-4	1g	$62	2026-04-30	Buy
TCI Chemical	D2193	(3S)-(-)-3-(Dimethylamino)pyrrolidine >98.0%(GC)	132883-44-4	5g	$186	2026-04-30	Buy
AstaTech	68457	(S)-3-DIMETHYLAMINOPYRROLIDINE 98%	132883-44-4	0.25G	$27	2026-04-30	Buy
AstaTech	68457	(S)-3-DIMETHYLAMINOPYRROLIDINE 98%	132883-44-4	1G	$77	2026-04-30	Buy

Product number	Packaging	Price	Buy
656704	1g	$109	Buy
D2193	1g	$62	Buy
D2193	5g	$186	Buy
68457	0.25G	$27	Buy
68457	1G	$77	Buy

(3S)-(-)-3-(Dimethylamino)pyrrolidine Chemical Properties,Uses,Production

Synthesis

The synthesis of (3S)-(-)-3-(dimethylamino)pyrrolidine is currently mainly based on L-malic acid, and is synthesized through reactions such as cyclization, reduction, persulfonation and deprotection, with an overall yield of 31.45%. Its structure is directly introduced by the methylamino group using the original 3 hydroxyl groups, avoiding the construction of the chiral center of the dimethylamino group. The process of synthesizing the intermediate 6(S)-1-benzylpyrrolidine has also been optimized, with a yield of 90%. (3S)-(-)-3-(dimethylamino)pyrrolidine was synthesized with a yield of 87% through substitution and reduction, which has important reference value for the synthesis of this intermediate. The synthetic reaction formula is shown in the figure below:

Synthesis of 132883-44-4

Figure 1 Synthetic reaction formula of (3S)-(-)-3-(dimethylamino)pyrrolidine

This synthetic route has the advantages of simple operation, cheap and readily available raw materials, and easy separation of products, which is beneficial to the application and production of this compound.

Chemical Properties

Colorless to light yellow liqui

Uses

(S)-()-3-(Dimethylamino)pyrrolidine can be used as a reactant in the syntheses of oxadiazolylthiazole and xanthone derivatives of biological importance.

(3S)-(-)-3-(Dimethylamino)pyrrolidine Preparation Products And Raw materials

Raw materials

Ethanol (S)-1-Benzyl-3-pyrrolidinol Pyridinium dichromate Potassium carbonate Triethylamine

Palladium Dimethylamine hydrochloride Tosyl chloride Hydrochloric acid (S)-(+)-Mandelic acid

Tetraethylammonium acetate tetrahydrate, 99 Dichloromethane (R)-(+)-1-Benzyl-3-pyrrolidinol Pyridine

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Preparation Products

(3S)-(-)-3-(Dimethylamino)pyrrolidine Suppliers

Global( 157)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Chengdu Aminotp Pharmaceutical Technology Co.,Ltd.	028-85755578 18140172005	sales@aminotp.com	China	296	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Sichuan Guanghan Bio-Tech Co., Ltd	+86-28-86127071	info@sino-produce.com	China	400	66
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64

Supplier	Advantage
Chengdu Aminotp Pharmaceutical Technology Co.,Ltd.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Capot Chemical Co., Ltd	66
Sichuan Guanghan Bio-Tech Co., Ltd	66
Pure Chemistry Scientific Inc.	62
Adamas Reagent, Ltd.	59
Accela ChemBio Co.,Ltd.	64

View Lastest Price from (3S)-(-)-3-(Dimethylamino)pyrrolidine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2022-01-26	(3S)-N,N-dimethylpyrrolidin-3-amine 132883-44-4		1KG	97.7%	100 tons	Honest Joy Holdings Limited
	2019-07-06	(3S)-(-)-3-(DIMETHYLAMINO)PYRROLIDINE 132883-44-4		1KG	98%	150KG	Career Henan Chemical Co

(3S)-N,N-dimethylpyrrolidin-3-amine
132883-44-4
$0.00
97.7%
Honest Joy Holdings Limited

(3S)-(-)-3-(DIMETHYLAMINO)PYRROLIDINE
132883-44-4
$0.00
98%
Career Henan Chemical Co

(3S)-(-)-3-(Dimethylamino)pyrrolidine Spectrum

(3S)-(-)-3-(DIMETHYLAMINO)PYRROLIDINE(132883-44-4)¹HNMR

132883-44-4((3S)-(-)-3-(Dimethylamino)pyrrolidine)Related Search:

L-N-[(4'-BOC)PIPERIDINO]PROLINE DANOFLOXACIN Danofloxacin mesylate Calebassine 1-Benzyl-3-(dimethylamino)pyrrolidine

(3S)-(-)-3-(Dimethylamino)pyrrolidine (1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane (3R)-(+)-3-(Dimethylamino)pyrrolidine 3-(Dimethylamino)pyrrolidine (R)-3-(Dimethylamino) pyrrolidine dihydrochloride

(1S,4S)-(-)-2-(4-FLUOROPHENYL)-2,5-DIAZABICYCLO[2.2.1]HEPTANE, HYDROBROMIDE GR 82334 CHAETOMIN Acetamide, N-methyl-N-(2,3,3a,6a-tetrahydro-2,4-methano-4H-furo(3,2-b) pyrrol-3-yl)-, (2R-(2-alpha,3-alpha,3a-beta,4-beta,6a-beta))- 2-(4-CHLOROBENZYL)-2,5-DIAZA-BICYCLO[2.2.1]HEPTANE

(1S,4S)-(-)-2-(4-METHYLPHENYL)-2,5-DIAZABICYCLO[2.2.1]HEPTANE, MALEATE SALT GR71251 (1S,4S)-2-METHYL-2,5-DIAZABICYCLO(2.2.1)HEPTANE 2HBR

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(3S)-(-)-3-(DIMETHYLAMINO)PYRROLIDINE 96+% DIMETHYL-PYRROLIDIN-3-YL-AMINE (S) (3S)-3-DIMETHYLAMINOPYRROLIDINE (3S)-DIMETHYL-PYRROLIDIN-3-YL-AMINE (3S)-N,N-DIMETHYL-3-PYRROLIDINAMINE (S)-DIMETHYL-PYRROLIDIN-3-YL-AMINE (S)-(-)-3-(DIMETHYLAMINO)PYRROLIDINE (S)-3-(DIMETHYLAMINO) PYRROLIDINE **DISCONTINUED** Alt H30661 (3S)-N,N-Dimethylpyrrolidin-3-amine S- N,N-diMethyl-3-PyrrolidinaMine 3-PyrrolidinaMine, N,N-diMethyl-, (3S)- (S)-(-)-3-(Dimethylamino)pyrrolidine 97% (3S)-(-)-3-(DIMETHYLAMINO)PYRROLIDINE hydrochloride (3S)-N (S)-N,N-Dimethyl-3-pyrrolidinamine,99%e.e. (3S)-(-)-3-(Dimethylamino)pyrrolidine> (S)-(?)-3-(Dimethylamino)pyrrolidine (3S)-(-)-3-(Dimethylamino)pyrrolidine HCL (3S)-(-)-3-(Dimethylamino)pyrrolidine - [D12657] (S)-N,N-dimethylpyrrolidin-3-amine (3S)-(-)-3-(Dimethylamino)pyrrolidine 132883-44-4 Asymmetric Synthesis Heterocyclic Building Blocks Pyrrolidines Chiral Building Blocks Chiral 3-Aminopyrrolidines 3-Aminopyrrolidines Amines (Chiral) 3-Aminopyrrolidines Amines (Chiral) Chiral 3-Aminopyrrolidines Chiral Building Blocks Synthetic Organic Chemistry chiral