Physalaemin
- CAS No.
- 2507-24-6
- Chemical Name:
- Physalaemin
- Synonyms
- FI 6422;Physalemin;PHYSALAEMIN;Physalaemine;PHYSALAEMIN ACOH 3H2O;Physalemin(7CI,8CI,9CI);Physalaemin, ≥97% (HPLC);GLP-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2;PYR-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2;PGLU-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2
- CBNumber:
- CB5674482
- Molecular Formula:
- C58H84N14O16S
- Molecular Weight:
- 1265.44
- MDL Number:
- MFCD00076375
- MOL File:
- 2507-24-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 1743.208±65.00 °C(Press: 760.00 Torr)(predicted) |
|---|---|
| Density | 1.331±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| storage temp. | −20°C |
| solubility | Soluble in DMSO |
| pka | 4.306±0.19(predicted) |
| Sequence | GLP-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2 |
| InChIKey | SHSUJLMLURFKID-PYQGFWJGNA-N |
| FDA UNII | H0T4KV6B9J |
Physalaemin price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | PPY-4030-V | Physalaemin | 2507-24-6 | 0.5mg | $150 | 2026-06-04 | Buy |
| Biosynth | PPY-4030 | Physalaemin | 25mg | $2086 | 2026-06-04 | Buy | |
| aablocks | AA002QAY | (3S)-4-[(2S)-2-[[(2S)-4-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxohexan-2-yl]amino]-1,4-dioxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-oxo-3-[[(2S)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]amino]butanoic acid ≥95% | 2507-24-6 | 1mg | $203 | 2026-05-28 | Buy |
| aablocks | AA002QAY | (3S)-4-[(2S)-2-[[(2S)-4-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxohexan-2-yl]amino]-1,4-dioxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-oxo-3-[[(2S)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]amino]butanoic acid ≥95% | 2507-24-6 | 2mg | $290 | 2026-05-28 | Buy |
| aablocks | AA002QAY | (3S)-4-[(2S)-2-[[(2S)-4-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxohexan-2-yl]amino]-1,4-dioxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-oxo-3-[[(2S)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]amino]butanoic acid ≥95% | 2507-24-6 | 5mg | $449 | 2026-05-28 | Buy |
Physalaemin Chemical Properties,Uses,Production
Description
Physalaemin is an oligopeptide that is originally derived from the skin of the South American frog Physalaemus fuscumaculatus. It belongs to the class of kinins and shares a similar chemical structure and mode of action with Substance P. It is a potent vasodilator and has hypotensive effects.
Uses
Physalaemin is a neuropeptide found in amphibians that has shown potential in the treatment of Sjogren's disease.
Biological Activity
Physalaemin is a non-mammalian tachykinin that selectively binds with high affinity to the neurokinin-1 (NK1) receptor.
in vitro
Physalaemin (PHY), an undecapeptide with the sequence pGlu-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2, is a member of the tachykinin family of neuropeptides. PHY is very close to the mammalian tachykinin substance P (SP) in its function and chemical composition, and SP is well studied and characterized. Physalaemin is a bradykinin potentiating peptide (BPP-5a).
target
Neurokinin-1 (NK1) receptor
References
[1] Grace CR, et al. Solution conformation of non-mammalian tachykinin physalaemin in lipid micelles by nuclear magnetic resonance. Biopolymers. 2011;96(3):252-9. DOI:10.1002/bip.21519
[2] Kobayashi J, Hydrolytic cleavage of pyroglutamyl-peptide bond. V. selective removal of pyroglutamic acid from biologically active pyroglutamylpeptides in high concentrations of aqueous methanesulfonic acid. Chem Pharm Bull (Tokyo). 2006 Jun;54(6):827-31. DOI:10.1248/CPB.54.827
[3] Hypotensive effect of eledoisin, physalaemin and related peptides in man DOI: 10.1007/BF00535905
[4] Physalaemin Inhibits Thyrotropin Secretion in Rats DOI: 10.1055/s-0029-1210457
[5] Action of Physalaemin on the Ionic Transport Across the Frog Skin: Archives of Physiology and Biochemistry: Vol 105, No DOI: 10.1055/s-0029-1210457
Physalaemin Preparation Products And Raw materials
Raw materials
Preparation Products
Physalaemin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 1010 | 55 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Creative Peptides | info@creative-peptides.com | United States | 6083 | 56 | |
| Nanjing Leon Biological Technology Co., Ltd. | 025-84523390 -127; 17705183659 | sales@njleonbiotech.com | China | 5501 | 55 |
| Nanjing Peptide Biotech Ltd. | 025-58361106-805 15951641583 | zhao.xu@njpeptide.com | China | 9976 | 55 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 | Caroline@youngshechem.com | China | 4725 | 58 |
View Lastest Price from Physalaemin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-03-06 | PHYSALAEMIN
2507-24-6
|
$1.00 | 1g | ≥98% | Career Henan Chemical Co |
-
- PHYSALAEMIN
2507-24-6
- $1.00
- ≥98%
- Career Henan Chemical Co
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