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ChemicalBook >> CAS DataBase List >>4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Structure
4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione structure
CAS No.
2093416-31-8
Chemical Name:
4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Synonyms
RMA-822;Poma-PEG4-NH2;Pomalidomide-PEG3-C2-NH2;Thalidomide-4-NH-PEG3-C2-NH2;Cereblon Ligand-Linker Conjugates 5;E3 ligase Ligand-Linker Conjugates 30;4-[[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione;4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;4-(12-amino-4,7,10-trioxa-1-azadodecan-1-yl)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione;4-[[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
CBNumber:
CB54849370
Molecular Formula:
C21H28N4O7
Molecular Weight:
448.47
MDL Number:
MFCD32063491
MOL File:
2093416-31-8.mol
MSDS File:
SDS
Last updated:2025-04-18 09:51:11
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4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Properties

Boiling point 694.2±55.0 °C(Predicted)
Density 1.361±0.06 g/cm3(Predicted)
pka 10.74±0.40(Predicted)

4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0099510 Pomalidomide-PEG3-C2-NH2 ≥98% 2093416-31-8 100mg $2618 2026-06-04 Buy
ChemScene CS-0099510 Pomalidomide-PEG3-C2-NH2 ≥98% 2093416-31-8 250mg $2743 2026-06-04 Buy
BroadPharm bp-40487 Pomalidomide-PEG3-amine 2093416-31-8 100MG $980 2026-05-24 Buy
DC Chemicals DC50057 E3 ligase Ligand-Linker Conjugates 30 >98% 2093416-31-8 100mg $550 2026-05-24 Buy
DC Chemicals DC50057 E3 ligase Ligand-Linker Conjugates 30 >98% 2093416-31-8 250mg $950 2026-05-24 Buy
Product number Packaging Price Buy
CS-0099510 100mg $2618 Buy
CS-0099510 250mg $2743 Buy
bp-40487 100MG $980 Buy
DC50057 100mg $550 Buy
DC50057 250mg $950 Buy

4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Chemical Properties, Uses, Production

Description

Pomalidomide-PEG3-C2-NH2 is a Pomalidomide-based cereblon ligand with a linker, which is a useful precursor for synthesis of PROTAC degraders. Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to tackle disease-causing proteins that have historically been highly challenging to target with conventional small molecules. PROTAC degraders are usually heterobifunctional small molecules consisting of two ligands joined by a linker: one ligand recruits and binds a protein of interest (POI) while the other recruits and binds an E3 ubiquitin ligase. Simultaneous binding of the POI and ligase by the PROTAC induces ubiquitylation of the POI and its subsequent degradation by the ubiquitin–proteasome system (UPS), after which the PROTAC is recycled to target another copy of the POI.

Uses

Pomalidomide-PEG3-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

IC 50

Cereblon

References

[1] Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019 Jan 24;62(2):448-466. DOI:10.1021/acs.jmedchem.8b00909

4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Preparation Products And Raw materials

Raw materials

Preparation Products

4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Suppliers

Global Suppliers ( 27)
Supplier Tel Email Country ProdList Advantage
Suzhou Highfine Biotech Co., Ltd 0512-69209928 18796809688 zhouyingxiang@highfine.com China 472 75
Daicel Chiral Technologies (China)CO.,LTD 021-50460086-9 15921403865 han_yajun@dctc.daicel.com China 7909 65
Shanghai Kewel Chemical Co., Ltd. 021-64609169 18901607656 greensnown@163.com China 9883 50
Chengdu J&B Technology Co., Ltd. 028-61186694 15608078506 609128801@qq.com China 853 55
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1644 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD 025-86755008 17751752005 hszhang@bestfluorodrug.com China 2357 58
QUALITY CONTROL SOLUTIONS LTD. +86-0755-66853366 +86-13670046396 export03@qcsrm.com China 24318 58
Xi'an Kaixin Biotechnology Co., Ltd 029-68881181 13619217766 3495811982@qq.com China 2816 58
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. +86-027-59232304 15387063101 1276242629@qq.com China 9977 58
Supplier Advantage
Suzhou Highfine Biotech Co., Ltd 75
Daicel Chiral Technologies (China)CO.,LTD 65
Shanghai Kewel Chemical Co., Ltd. 50
Chengdu J&B Technology Co., Ltd. 55
Jilin Province Woda Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD 58
QUALITY CONTROL SOLUTIONS LTD. 58
Xi'an Kaixin Biotechnology Co., Ltd 58
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. 58

2093416-31-8 (4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione) Related Search:

Pomalidomide-PEG1-CO2H Pomalidomide-PEG2-CO2H Pomalidomide-PEG5-CO2H E3 ligase Ligand-Linker Conjugates 50 Pomalidomide-PEG3-CO2H
Pomalidomide-PEG2-N3 Pomalidomide-PEG4-azide Pomalidomide-PEG2-butyl iodide E3 Ligase Ligand-Linker Conjugates 22 Pomalidomide-PEG4-CO2H
E3 Ligase Ligand-Linker Conjugates 1 Pomalidomide-PEG1-azide Pomalidomide-O-C4-NH2 Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]- Pomalidomide-PEG3-N3
Pomalidomide-PEG6-butyl iodide

1of4

E3 ligase Ligand-Linker Conjugates 30 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Cereblon Ligand-Linker Conjugates 5 Pomalidomide-PEG3-C2-NH2 1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)- 4-[[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione Thalidomide-4-NH-PEG3-C2-NH2 4-(12-amino-4,7,10-trioxa-1-azadodecan-1-yl)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione 4-((2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione?, Pomalidomide-PEG3-C2-NH2 RMA-822 4-[[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione Poma-PEG4-NH2 2093416-31-8