Pomalidomide-PEG6-butyl iodide
- CAS No.
- 1835705-74-2
- Chemical Name:
- Pomalidomide-PEG6-butyl iodide
- Synonyms
- Pomalidomide-2-2-2-2-2-2-6-I;Pomalidomide-PEG6-butyl iodide;Pomalidomide-PEG?-butyl iodide;Pomalidomide-PEG6-butyl iodide;N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-24-iodo-3,6,9,12,15,18-hexaoxatetracosanamide;Acetamide, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-2-[(21-iodo-3,6,9,12,15-pentaoxaheneicos-1-yl)oxy]-;N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-24-iodo-3,6,9,12,15,18-hexaoxatetracosanamide, Crosslinker?E3 Ligase ligand conjugate, Pomalidomide-2-2-2-2-2-2-6-I, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
- CBNumber:
- CB04919986
- Molecular Formula:
- C31H44IN3O11
- Molecular Weight:
- 761.6
- MDL Number:
- MFCD32173803
- MOL File:
- 1835705-74-2.mol
- MSDS File:
- SDS
| Boiling point | 853.5±65.0 °C(Predicted) |
|---|---|
| Density | 1.448±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO : 100 mg/mL (131.30 mM; Need ultrasonic) |
| pka | 10.68±0.40(Predicted) |
| form | Solid |
| color | White to off-white |
| InChIKey | NPWUUZRWHPEICJ-UHFFFAOYSA-N |
| SMILES | ICCCCCCOCCOCCOCCOCCOCCOCC(NC1=CC=CC2=C1C(N(C3CCC(NC3=O)=O)C2=O)=O)=O |
| UNSPSC Code | 12352101 |
| NACRES | NA.22 |
Pomalidomide-PEG6-butyl iodide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 903442 | Pomalidomide-PEG6-butyl iodide ≥95% | 1835705-74-2 | 50MG | $555 | 2026-04-30 | Buy |
| ChemScene | CS-0120073 | Pomalidomide-PEG6-butyl iodide ≥98% | 1835705-74-2 | 25mg | $305 | 2026-06-04 | Buy |
| ChemScene | CS-0120073 | Pomalidomide-PEG6-butyl iodide ≥98% | 1835705-74-2 | 50mg | $480 | 2026-06-04 | Buy |
| BroadPharm | bp-40514 | Pomalidomide-amido-PEG6-buty iodide | 1835705-74-2 | 25MG | $540 | 2026-05-24 | Buy |
| BroadPharm | bp-40514 | Pomalidomide-amido-PEG6-buty iodide | 1835705-74-2 | 50MG | $980 | 2026-05-24 | Buy |
Pomalidomide-PEG6-butyl iodide Chemical Properties,Uses,Production
Uses
Protein degrader builiding block Pomalidomide-PEG6-butyl iodide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant iodoalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant iodo group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
reaction suitability
reactivity: sulfuryl reactive
reagent type: ligand-linker conjugate
IC 50
Cereblon
Pomalidomide-PEG6-butyl iodide Preparation Products And Raw materials
Raw materials
Preparation Products
Pomalidomide-PEG6-butyl iodide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 | 1924344760@qq.com | China | 4229 | 58 |
| Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 | 1927928688@qq.com | China | 1644 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Changsha Bono New Materials Technology Co., Ltd. | 18191076804 | asherw9@hotmail.com | China | 2373 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 54996 | 58 |
| Zhengzhou convergence chemical co., LTD | 037155153829 18003835034 | 3897192574@qq.com | China | 9982 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 9067 | 58 |
View Lastest Price from Pomalidomide-PEG6-butyl iodide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | Pomalidomide-PEG6-butyl iodide
1835705-74-2
|
$71.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2025-06-07 | Pomalidomide-2-2-2-2-2-2-6-I
1835705-74-2
|
100mg | >95.00% | 100mg | Xian confluore Biological Technology Co., Ltd. |
-
- Pomalidomide-PEG6-butyl iodide
1835705-74-2
- $71.00
- TargetMol Chemicals Inc.
-
- Pomalidomide-2-2-2-2-2-2-6-I
1835705-74-2
- $0.00
- >95.00%
- Xian confluore Biological Technology Co., Ltd.
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