TCO-PEG8-amine
- CAS No.
- 2353409-92-2
- Chemical Name:
- TCO-PEG8-amine
- Synonyms
- TCO-PEG8-amine;(4E)-TCO-PEG8-amine;Cyclooct-4-en-1-yl (26-amino-3,6,9,12,15,18,21,24-octaoxahexacosyl)carbamate;5,8,11,14,17,20,23,26-Octaoxa-2-azaoctacosanoic acid, 28-amino-, 4-cycloocten-1-yl ester
- CBNumber:
- CB54849693
- Molecular Formula:
- C27H52N2O10
- Molecular Weight:
- 564.71
- MDL Number:
- MFCD31811519
- MOL File:
- 2353409-92-2.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
TCO-PEG8-amine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0114643 | TCO-PEG8-amine ≥98% | 2353409-92-2 | 100mg | $651 | 2026-06-04 | Buy |
| ChemScene | CS-0114643 | TCO-PEG8-amine ≥98% | 2353409-92-2 | 250mg | $1461 | 2026-06-04 | Buy |
| BroadPharm | bp-24162 | TCO-PEG8-amine 98% | 2353409-92-2 | 25MG | $230 | 2026-05-24 | Buy |
| BroadPharm | bp-24162 | TCO-PEG8-amine 98% | 2353409-92-2 | 50MG | $380 | 2026-05-24 | Buy |
| BroadPharm | bp-24162 | TCO-PEG8-amine 98% | 2353409-92-2 | 100MG | $650 | 2026-05-24 | Buy |
TCO-PEG8-amine Chemical Properties, Uses, Production
Description
TCO-PEG8-amine is an aqueous soluble heterobifunctional crosslinker consisting of a TCO and an amine group (NH2). Amine is very reactive with active NHS ester or with carboxylic acid in the presence of of activators suh as EDC. TCO moiety enable click chemistry with tetrazine molecule. The inverse-electron demand Diels-Alder cycloaddition of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity.
Uses
TCO-PEG8-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238. DOI:10.1016/j.apsb.2019.08.001
TCO-PEG8-amine Preparation Products And Raw materials
Raw materials
Preparation Products
TCO-PEG8-amine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BioPharmaMatrix,Inc. | 0510-86010668 13395169561; | sales@biopharmamatrix.com | China | 4982 | 55 |
| Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 | 1924344760@qq.com | China | 4229 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shaanxi Xinyan Bomei Biotechnology Co., Ltd. | 13892832556 | 2440688701@qq.com | China | 1978 | 58 |
| Zhengzhou Akem Chemical Co., Ltd | 13303867194 | 770406999@qq.com | China | 9949 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd | 0431-80514535 19917294565 | et@chemextension.com | China | 5061 | 58 |
| shanghai Yanfeng biochemical technology Co.,LTD | 17721070236 13611955358 | yanfen2023@126.com | China | 2995 | 58 |
| Shanghai Zhiyun Biotechnology Co., Ltd | 13119135307 | China | 2766 | 58 | |
| Jilin Chinese Academy of Sciences-yanshen Technology | 18143011203 | ET-market@chemextension.com | China | 38904 | 58 |
