Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate
- CAS No.
- 123770-62-7
- Chemical Name:
- Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate
- Synonyms
- Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate;ethyl 5-(hydroxymethyl)-1,2-oxazole-3-carboxylate;5-(hydroxymethyl)-3-isoxazolecarboxylic acid ethyl ester;5-(Hydroxymethyl)isoxazole-3-carboxylic acid ethyl ester;3-Isoxazolecarboxylic acid, 5-(hydroxymethyl)-, ethyl ester
- CBNumber:
- CB5485136
- Molecular Formula:
- C7H9NO4
- Molecular Weight:
- 171.15
- MDL Number:
- MFCD08273501
- MOL File:
- 123770-62-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2934999090 |
Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | YEA77062 | Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate | 123770-62-7 | 5g | $354 | 2026-06-05 | Buy |
| Matrix Scientific | 125927 | Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate | 123770-62-7 | 500.00mg | $122 | 2026-05-18 | Buy |
| Matrix Scientific | 125927 | Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate | 123770-62-7 | 1.00g | $164 | 2026-05-18 | Buy |
| Matrix Scientific | 125927 | Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate | 123770-62-7 | 5.00g | $654 | 2026-05-18 | Buy |
| Synthonix | E37262 | Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate 90+% | 123770-62-7 | 100mg | $16 | 2026-05-06 | Buy |
Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate Chemical Properties, Uses, Production
Synthesis
626-35-7
107-19-7
123770-62-7
The general procedure for the synthesis of ethyl 5-hydroxymethylisoxazole-3-carboxylate from ethyl nitroacetate and 2-propyn-1-ol was as follows: intermediate 4- Preparation of ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate. In an Ace pressure tube, 2-propyn-1-ol (1.0 mL, 16.76 mmol) and ethyl nitroacetate (3.79 mL, 33.52 mmol) were dissolved in ethanol (23.5 mL), followed by the addition of 1,4-diazabicyclo[2.2.2]octane (DABCO, 0.194 g, 1.68 mmol). The reaction tube was sealed and the reaction was heated at 80 °C for 72 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was concentrated to dryness under reduced pressure. The resulting residue was purified by fast column chromatography on silica gel, the eluent being a mixture of dichloromethane and methanol (methanol v/v fraction 0% to 6%), resulting in ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate 2.32 g in 81% yield as an oil.ESI/APCI (+): m/z 172 ([M+H]+).
References
[1] European Journal of Organic Chemistry, 2007, # 26, p. 4352 - 4359
[2] Journal of the American Chemical Society, 2014, vol. 136, # 48, p. 16792 - 16799
[3] Patent: WO2010/142801, 2010, A1. Location in patent: Page/Page column 147
[4] Chemistry - A European Journal, 2012, vol. 18, # 7, p. 2081 - 2093
[5] European Journal of Organic Chemistry, 2016, vol. 2016, # 27, p. 4643 - 4655
Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| Nanjing Credit Trading Co.,Ltd | 025-52164950 | Googlexu_0114@sina.com | China | 644 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Modachem Shanghai Co., Ltd | +86 (0)21 51320687 51371369 1744605818 | China | 1576 | 58 | |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9781 | 50 |
| Nanjing Chalf-Pharm Technology Co., Ltd. | 025-57018978 18251899859 | sales@chalf-pharm.com | China | 5855 | 50 |
| Shanghai XinKai Chemical Technology Co., Ltd. | 021-58930698 15921516558 | zhangyichao84@126.com | China | 979 | 55 |
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