2-FLUORO-6-HYDROXYBENZONITRILE
- CAS No.
- 140675-43-0
- Chemical Name:
- 2-FLUORO-6-HYDROXYBENZONITRILE
- Synonyms
- 2-CYANO-3-FLUOROPHENOL;6-FLUOROSALICYLONITRILE;2-fuoro-6-hydroxybenzonitrle;2-fluoro-6-hydroxybenzonitrle;2-FLUORO-6-HYDROXYBENZONITRILE;Benzonitrile, 2-fluoro-6-hydroxy-;2-Fluoro-6-hydroxybenzonitrile >2-Fluoro-6-hydroxybenzonitrile 99%;2-FLUORO-6-HYDROXYBENZONITRILE,98+%;Benzonitrile, 2-fluoro-6-hydroxy- (9CI)
- CBNumber:
- CB5494132
- Molecular Formula:
- C7H4FNO
- Molecular Weight:
- 137.11
- MDL Number:
- MFCD03428592
- MOL File:
- 140675-43-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2-Fluoro-6-hydroxybenzonitrile >98.0%(GC)(T) | F0985 | 1g | $22 |
| 2-Fluoro-6-hydroxybenzonitrile >98.0%(GC)(T) | F0985 | 5g | $89 |
| 2-Fluoro-6-hydroxybenzonitrile | FF64144 | 100g | $389 |
| 2-Fluoro-6-hydroxybenzonitrile | FF64144 | 250g | $715 |
| 2-Fluoro-6-hydroxybenzonitrile | FF64144 | 500g | $1170 |
| More product size | |||
| Melting point | 156-158°C |
|---|---|
| Boiling point | 257.5±25.0 °C(Predicted) |
| Density | 1.34±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 6.17±0.10(Predicted) |
| color | White to Light yellow |
| BRN | 8403914 |
| InChI | InChI=1S/C7H4FNO/c8-6-2-1-3-7(10)5(6)4-9/h1-3,10H |
| InChIKey | YEBHNFDMNFHZFF-UHFFFAOYSA-N |
| SMILES | C(#N)C1=C(O)C=CC=C1F |
| CAS DataBase Reference | 140675-43-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H312-H315-H319-H331-H335 | |||||||||
| Precautionary statements | P261-P280-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 20/22-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| RIDADR | 3276 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2926907090 | |||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
2-FLUORO-6-HYDROXYBENZONITRILE price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F0985 | 2-Fluoro-6-hydroxybenzonitrile >98.0%(GC)(T) | 140675-43-0 | 1g | $22 | 2026-04-30 | Buy |
| TCI Chemical | F0985 | 2-Fluoro-6-hydroxybenzonitrile >98.0%(GC)(T) | 140675-43-0 | 5g | $89 | 2026-04-30 | Buy |
| Biosynth | FF64144 | 2-Fluoro-6-hydroxybenzonitrile | 140675-43-0 | 100g | $389 | 2026-06-04 | Buy |
| Biosynth | FF64144 | 2-Fluoro-6-hydroxybenzonitrile | 140675-43-0 | 250g | $715 | 2026-06-04 | Buy |
| Biosynth | FF64144 | 2-Fluoro-6-hydroxybenzonitrile | 140675-43-0 | 500g | $1170 | 2026-06-04 | Buy |
2-FLUORO-6-HYDROXYBENZONITRILE Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powder
Synthesis
94088-46-7
140675-43-0
General procedure for the synthesis of 2-fluoro-6-hydroxybenzonitrile from 2-fluoro-6-methoxybenzonitrile: 1. 151 g (1 mol) of 2-fluoro-6-methoxybenzonitrile and 346.5 g (3 mol) of aqueous pyridinium solution were added to a 2 liter flask. Hydrogen chloride gas was slowly passed into the flask under a protective atmosphere. 2. The reaction mixture was slowly heated to 190 °C and stirred at this temperature for 5 hours. 3. Upon completion of the reaction, the mixture was cooled to room temperature overnight with slow stirring. 4. 1000 ml of water was added to the cooled mixture, and the mixture was heated to 80 °C. 5. 1000 ml of methyl tert-butyl ether was added and mixed thoroughly to separate the organic and aqueous phases. The aqueous phase was back-extracted twice with 500 ml of methyl tert-butyl ether. 6. Combine all the methyl tert-butyl ether phases and wash once with 800 ml of 10% aqueous sodium hydroxide and once with 400 ml of water. 7. Combine the two aqueous phases and adjust the pH to 2 with concentrated hydrochloric acid, then extract three times with 500 ml of dichloromethane. 8. The organic phases were combined and washed once with 10% hydrochloric acid. 9. The organic phases were dried with anhydrous sodium sulfate. 10. Finally, the solvent was removed by distillation under vacuum to give 120 g (87% yield) of 2-fluoro-6-hydroxybenzonitrile with >99% purity, and the product was confirmed by GC and 1H NMR (D6-dimethylsulfoxide, δ=6.85 ppm (m,2H,aryl H), 7.55 ppm (q,1H,aryl H), 11.7 ppm (s,1H,OH)) structure.
References
[1] Patent: WO2006/56433, 2006, A2. Location in patent: Page/Page column 30
[2] Patent: WO2007/93530, 2007, A1. Location in patent: Page/Page column 244-245
2-FLUORO-6-HYDROXYBENZONITRILE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-15225627621 +86-13213167925 | jiuyitime@fdachem.com | China | 16505 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10399 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| Fuxin Pharmaceutical | +86-021-021-50872116 | contact@fuxinpharm.com | China | 9976 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14301 | 58 |
| Baoji Guokang Healthchem Co., Ltd. | +86-0917-3909592 +86-13892490616 | gksales1@gk-bio.com | China | 9037 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52693 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +8619957148339 | market18@leapchem.com | China | 24569 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49859 | 58 |
View Lastest Price from 2-FLUORO-6-HYDROXYBENZONITRILE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-02 | 2-FLUORO-6-HYDROXYBENZONITRILE
140675-43-0
|
$2.00-5.00 | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2021-07-13 | 2-FLUORO-6-HYDROXYBENZONITRILE
140675-43-0
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 2-FLUORO-6-HYDROXYBENZONITRILE
140675-43-0
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 2-FLUORO-6-HYDROXYBENZONITRILE
140675-43-0
- $2.00-5.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 2-FLUORO-6-HYDROXYBENZONITRILE
140675-43-0
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 2-FLUORO-6-HYDROXYBENZONITRILE
140675-43-0
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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