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(4-Methyl-piperazin-1-yl)-acetic acid

(4-Methyl-piperazin-1-yl)-acetic acid Structure
(4-Methyl-piperazin-1-yl)-acetic acid structure
CAS No.
54699-92-2
Chemical Name:
(4-Methyl-piperazin-1-yl)-acetic acid
Synonyms
2-(4-METHYLPIPERAZIN-1-YL)ACETIC ACID;(4-METHYL-1-PIPERAZINYL)ACETIC ACID;AKOS BB-5221;AKOS BBS-00002665;(4-METHYLPIPERAZINO)ACETIC ACID;4-METHYL PIPERAZINE-ACETIC ACID;4-METHYLPIPERAZINE-1-ACETIC ACID;4-Methyl-1-piperazin acetic acid;4-METHYL-1-PIPERAZINE ACETIC ACID;1-Piperazineacetic acid, 4-Methyl-
CBNumber:
CB5494642
Molecular Formula:
C7H14N2O2
Molecular Weight:
158.2
MDL Number:
MFCD03444554
MOL File:
54699-92-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:53:35
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(4-Methyl-piperazin-1-yl)-acetic acid Properties

Melting point 130-133°C
Boiling point 278℃
Density 1.123
Flash point 122℃
storage temp. Sealed in dry,Room Temperature
form solid
pka 1.85±0.10(Predicted)
color Off-white
InChI InChI=1S/C7H14N2O2/c1-8-2-4-9(5-3-8)6-7(10)11/h2-6H2,1H3,(H,10,11)
InChIKey JCXZKUZXVQKENT-UHFFFAOYSA-N
SMILES N1(CC(O)=O)CCN(C)CC1
CAS DataBase Reference 54699-92-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard Codes  Xi
Risk Statements  36/37/38-41-37/38
Safety Statements  26-36/37/39-39
HazardClass  IRRITANT
HS Code  2933599590

(4-Methyl-piperazin-1-yl)-acetic acid price More Price(59)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
AstaTech 63518 4-METHYL-1-PIPERAZINE ACETIC ACID 97% 54699-92-2 1G $10 2026-04-30 Buy
AstaTech 63518 4-METHYL-1-PIPERAZINE ACETIC ACID 97% 54699-92-2 5G $33 2026-04-30 Buy
AstaTech 63518 4-METHYL-1-PIPERAZINE ACETIC ACID 97% 54699-92-2 25G $154 2026-04-30 Buy
Apolloscientific OR17668 (4-Methylpiperazin-1-yl)acetic acid 97% 54699-92-2 1g $56 2026-06-04 Buy
Apolloscientific OR17668 (4-Methylpiperazin-1-yl)acetic acid 97% 54699-92-2 10g $138 2026-06-04 Buy
Product number Packaging Price Buy
63518 1G $10 Buy
63518 5G $33 Buy
63518 25G $154 Buy
OR17668 1g $56 Buy
OR17668 10g $138 Buy

(4-Methyl-piperazin-1-yl)-acetic acid Chemical Properties, Uses, Production

Uses

(Carboxymethyl)-N'-methylpiperazine acts as a potential antibacterial compound, due to its nocathiacin analog.

Uses

(Carboxymethyl)-N''-methylpiperazine acts as a potential antibacterial compound, due to its nocathiacin analog.

Synthesis

ethyl 2-(4-methylpiperazin-1-yl)acetate

28920-67-4

(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID

54699-92-2

b) Synthesis of 4-methyl-1-piperazinylacetic acid Ethyl (4-methyl-1-piperazinyl) acetate (1.3 g, 6.50 mmol, 1.0 eq.) was dissolved in 8N hydrochloric acid and the reaction was stirred at 95°C for 16 hours. After completion of the reaction, the reaction solution was concentrated by vacuum rotary evaporator. The remaining hydrochloric acid was neutralized with sodium bicarbonate solution and subsequently extracted with ethyl acetate (3 x 10 ml). The organic phases were combined, washed sequentially with water and saturated saline and dried over anhydrous sodium sulfate. The organic solvent was removed by distillation under reduced pressure to afford the target product 4-methyl-1-piperazineacetic acid in 54.5% yield (0.6 g).LC-MS (ESI) analysis: theoretical mass: 158.0; measured mass: 159.1 [M + H]+ (retention time: 0.102 min).

References

[1] Patent: WO2013/53983, 2013, A1. Location in patent: Page/Page column 38
[2] Journal of Medicinal Chemistry, 2000, vol. 43, # 8, p. 1489 - 1494
[3] Patent: EP2107054, 2009, A1. Location in patent: Page/Page column 26

(4-Methyl-piperazin-1-yl)-acetic acid synthesis

60-29-7
54699-92-2
Synthesis of (4-Methyl-piperazin-1-yl)-acetic acid from Diethyl ether

(4-Methyl-piperazin-1-yl)-acetic acid Preparation Products And Raw materials

Raw materials

1-Methylpiperazine Ethyl bromoacetate Diethyl ether Benzene Ethyl acetate
Methanol Sodium hydroxide 1-Piperazineacetic acid, 4-methyl-, 1,1-dimethylethyl ester ethyl 2-(4-methylpiperazin-1-yl)acetate 4-Methyl-1-piperazineacetic acid methyl ester
Bromoacetic acid Methyl chloroacetate Benzyl 2-bromoacetate

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Preparation Products

(4-Methyl-piperazin-1-yl)-acetic acid Suppliers

Global Suppliers ( 129)
Supplier Tel Email Country ProdList Advantage
Jinan Jiachang Pharmaceutical Technology Co. , Ltd. 15063360100 wangxiaojiandy@163.com China 229 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
ChemFuture PharmaTech (Jiangsu) Ltd 5108538618 suger.wang@chemfuture.com China 832 65
ForeChem (Nantong) Technology Co.,Ltd. 513-85982855 18921614129 sales@xianxingpharm.com China 2712 61
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Wujiang Suke Medical Technology Co., Ltd. +86-512-6320-2019 China 28 60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Supplier Advantage
Jinan Jiachang Pharmaceutical Technology Co. , Ltd. 58
J & K SCIENTIFIC LTD. 76
ChemFuture PharmaTech (Jiangsu) Ltd 65
ForeChem (Nantong) Technology Co.,Ltd. 61
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Wujiang Suke Medical Technology Co., Ltd. 60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64
Jia Xing Isenchem Co.,Ltd 66
Accela ChemBio Co.,Ltd. 64

View Latest Price from (4-Methyl-piperazin-1-yl)-acetic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(4-Methyl-piperazin-1-yl)-aceticacid pictures 2022-01-15 (4-Methyl-piperazin-1-yl)-aceticacid
54699-92-2
 1KG 97.3% 100 tons Honest Joy Holdings Limited
(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID pictures 2020-01-05 (4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID
54699-92-2
 $9.80 1g ≥99% 100kg Career Henan Chemical Co

(4-Methyl-piperazin-1-yl)-acetic acid Spectrum

(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID(54699-92-2)1HNMR

54699-92-2 ((4-Methyl-piperazin-1-yl)-acetic acid) Related Search:

1-Piperazineaceticacid, 4-(phenylmethyl)-, hydrazide cinepazet Cinepazic Acid Fmoc-4-carboxymethyl-piperazine Ethyl 2-(4-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]piperazino)acetate
AKOS BB-5220 4-[2-(Fmoc-amino)ethyl]-1-piperazineacetic acid dihydrochloride Apicycline Methyl 7-(4-chlorobenzyl)-5,8-dioxohexahydro[1,3]thiazolo[3,4-a]pyrazine-3-carboxylate 4-(4-Isopropylphenyl)-2-(4-methylpiperazino)-4-oxobutanoic acid
4-(4-Methylphenyl)-2-(4-methylpiperazino)-4-oxobutanoic acid 4-(4-Bromophenyl)-2-(4-methylpiperazinyl)-4-oxobutanoic acid Methyl 5,8-dioxo-7-[2-(2-pyridinyl)ethyl]hexahydro[1,3]thiazolo[3,4-a]pyrazine-3-carboxylate Methyl 7-(2-([3-chloro-5-(trifluoromethyl)-2-pyridinyl]amino)ethyl)-5,8-dioxohexahydro[1,3]thiazolo[3,4-a]pyrazine-3-carboxylate 4-[4-(tert-Butyl)phenyl]-2-(4-methylpiperazino)-4-oxobutanoic acid
Methyl 7-benzyl-5,8-dioxohexahydro[1,3]thiazolo[3,4-a]pyrazine-3-carboxylate Methyl 5,8-dioxo-7-phenethylhexahydro[1,3]thiazolo[3,4-a]pyrazine-3-carboxylate 4-(4-Chlorophenyl)-2-(4-methylpiperazino)-4-oxobutanoic acid

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1-Piperazineaceticacid,4-methyl-(9CI) (4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID >98% 1-Piperazineacetic acid, 4-Methyl- N-(Carboxymethyl)-N'-methylpiperazine (Carboxymethyl)-N'-methylpiperazine AKOS BB-5221 AKOS BBS-00002665 4-METHYLPIPERAZINE-1-ACETIC ACID 4-METHYL PIPERAZINE-ACETIC ACID (4-METHYLPIPERAZINO)ACETIC ACID 4-METHYL-1-PIPERAZINE ACETIC ACID (4-Methylpiperazino)acetic acid 4-Methylpiperazine-1-acetic acid (4-Methyl-piperazin-1-yl)-aceticaci (4-Methyl-piperazin-1-yl)-acetic ac 4-Methyl-1-piperazin acetic acid 4-Methyl-1-piperazine acetic acid, 95% (4-METHYL-1-PIPERAZINYL)ACETIC ACID 2-(4-METHYLPIPERAZIN-1-YL)ACETIC ACID (4-Methyl-piperazin-1-yl)-acetic acid 54699-92-2 piperazines PIPERIDINE