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(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID

(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID structure

CAS No.: 54699-92-2

Chemical Name:: (4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID

Synonyms: AKOS BB-5221;AKOS BBS-00002665;4-METHYL PIPERAZINE-ACETIC ACID;(4-METHYLPIPERAZINO)ACETIC ACID;4-METHYLPIPERAZINE-1-ACETIC ACID;4-Methyl-1-piperazin acetic acid;4-METHYL-1-PIPERAZINE ACETIC ACID;1-Piperazineacetic acid, 4-Methyl-;(Carboxymethyl)-N'-methylpiperazine;(4-METHYL-1-PIPERAZINYL)ACETIC ACID

CBNumber:: CB5494642

Molecular Formula:: C7H14N2O2

Molecular Weight:: 158.2

MDL Number:: MFCD03444554

MOL File:: 54699-92-2.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:52

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(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID Properties

Melting point	130-133°C
Boiling point	278℃
Density	1.123
Flash point	122℃
storage temp.	Sealed in dry,Room Temperature
form	solid
pka	1.85±0.10(Predicted)
color	Off-white
InChI	InChI=1S/C7H14N2O2/c1-8-2-4-9(5-3-8)6-7(10)11/h2-6H2,1H3,(H,10,11)
InChIKey	JCXZKUZXVQKENT-UHFFFAOYSA-N
SMILES	N1(CC(O)=O)CCN(C)CC1
CAS DataBase Reference	54699-92-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard Codes	Xi
Risk Statements	36/37/38-41-37/38
Safety Statements	26-36/37/39-39
HazardClass	IRRITANT
HS Code	2933599590

(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	C180700	(Carboxymethyl)-N''-methylpiperazine	54699-92-2	2.5g	$1320	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0015537	(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID 95.00%	54699-92-2	1G	$637.56	2021-12-16	Buy
SynQuest Laboratories	4H58-1-28	2-(4-Methylpiperazin-1-yl)acetic acid 98.0%	54699-92-2	5G	$237	2021-12-16	Buy
Matrix Scientific	008488	(4-Methyl-piperazin-1-yl)-acetic acid	54699-92-2	5g	$237	2021-12-16	Buy
AK Scientific	W6892	(4-Methyl-1-piperazinyl)aceticacid	54699-92-2	1g	$34	2021-12-16	Buy

Product number	Packaging	Price	Buy
C180700	2.5g	$1320	Buy
CHM0015537	1G	$637.56	Buy
4H58-1-28	5G	$237	Buy
008488	5g	$237	Buy
W6892	1g	$34	Buy

(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID Chemical Properties,Uses,Production

Uses

(Carboxymethyl)-N'-methylpiperazine acts as a potential antibacterial compound, due to its nocathiacin analog.

Uses

(Carboxymethyl)-N''-methylpiperazine acts as a potential antibacterial compound, due to its nocathiacin analog.

Synthesis

28920-67-4

54699-92-2

b) Synthesis of 4-methyl-1-piperazinylacetic acid Ethyl (4-methyl-1-piperazinyl) acetate (1.3 g, 6.50 mmol, 1.0 eq.) was dissolved in 8N hydrochloric acid and the reaction was stirred at 95°C for 16 hours. After completion of the reaction, the reaction solution was concentrated by vacuum rotary evaporator. The remaining hydrochloric acid was neutralized with sodium bicarbonate solution and subsequently extracted with ethyl acetate (3 x 10 ml). The organic phases were combined, washed sequentially with water and saturated saline and dried over anhydrous sodium sulfate. The organic solvent was removed by distillation under reduced pressure to afford the target product 4-methyl-1-piperazineacetic acid in 54.5% yield (0.6 g).LC-MS (ESI) analysis: theoretical mass: 158.0; measured mass: 159.1 [M + H]+ (retention time: 0.102 min).

References

[1] Patent: WO2013/53983, 2013, A1. Location in patent: Page/Page column 38
[2] Journal of Medicinal Chemistry, 2000, vol. 43, # 8, p. 1489 - 1494
[3] Patent: EP2107054, 2009, A1. Location in patent: Page/Page column 26

(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID synthesis

Synthesis of (4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID from Diethyl ether

(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID Preparation Products And Raw materials

Raw materials

1-Methylpiperazine Ethyl bromoacetate Diethyl ether Benzene Ethyl acetate

Methanol Sodium hydroxide 1-Piperazineacetic acid, 4-methyl-, 1,1-dimethylethyl ester ethyl 2-(4-methylpiperazin-1-yl)acetate 4-METHYL-1-PIPERAZINEACETIC ACID METHYL ESTER

Bromoacetic acid Methyl chloroacetate Benzyl 2-bromoacetate

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Preparation Products

(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID Suppliers

Global( 125)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Chembon Pharmaceutical Co., Ltd.	+86-28-8425-2981		CHINA	722	55
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49730	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29804	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10035	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58
Nanjing Hengbei Chemicals Co., Ltd.	+86-25-58393656	sales@hengbeichem.cn	China	6854	58

Supplier	Advantage
Chembon Pharmaceutical Co., Ltd.	55
Changzhou Ansciep Chemical Co., Ltd.	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Fuxin Pharmaceutical	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Nanjing Hengbei Chemicals Co., Ltd.	58

View Lastest Price from (4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2022-01-15	(4-Methyl-piperazin-1-yl)-aceticacid 54699-92-2	US $0.00 / KG	1KG	97.3%	100 tons	Honest Joy Holdings Limited
	2020-01-05	(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID 54699-92-2	US $9.80 / KG	1g	≥99%	100kg	Career Henan Chemical Co

(4-Methyl-piperazin-1-yl)-aceticacid
54699-92-2
US $0.00 / KG
97.3%
Honest Joy Holdings Limited

(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID
54699-92-2
US $9.80 / KG
≥99%
Career Henan Chemical Co

(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID Spectrum

(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID(54699-92-2)¹HNMR

54699-92-2((4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID)Related Search:

Cinepazic Acid cinepazet 1-Piperazineaceticacid, 4-(phenylmethyl)-, hydrazide Fmoc-4-carboxymethyl-piperazine 4-[2-(FMOC-AMINO)ETHYL]-1-PIPERAZINEACETIC ACID DIHYDROCHLORIDE

ETHYL 2-(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)ACETATE AKOS BB-5220 Apicycline 4-(4-ISOPROPYLPHENYL)-2-(4-METHYLPIPERAZINO)-4-OXOBUTANOIC ACID METHYL 7-(2-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]AMINO)ETHYL)-5,8-DIOXOHEXAHYDRO[1,3]THIAZOLO[3,4-A]PYRAZINE-3-CARBOXYLATE

4-[4-(TERT-BUTYL)PHENYL]-2-(4-METHYLPIPERAZINO)-4-OXOBUTANOIC ACID METHYL 7-(4-CHLOROBENZYL)-5,8-DIOXOHEXAHYDRO[1,3]THIAZOLO[3,4-A]PYRAZINE-3-CARBOXYLATE 4-(4-CHLOROPHENYL)-2-(4-METHYLPIPERAZINO)-4-OXOBUTANOIC ACID METHYL 7-BENZYL-5,8-DIOXOHEXAHYDRO[1,3]THIAZOLO[3,4-A]PYRAZINE-3-CARBOXYLATE METHYL 5,8-DIOXO-7-PHENETHYLHEXAHYDRO[1,3]THIAZOLO[3,4-A]PYRAZINE-3-CARBOXYLATE

METHYL 5,8-DIOXO-7-[2-(2-PYRIDINYL)ETHYL]HEXAHYDRO[1,3]THIAZOLO[3,4-A]PYRAZINE-3-CARBOXYLATE 4-(4-BROMOPHENYL)-2-(4-METHYLPIPERAZINYL)-4-OXOBUTANOIC ACID 4-(4-METHYLPHENYL)-2-(4-METHYLPIPERAZINO)-4-OXOBUTANOIC ACID

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1-Piperazineaceticacid,4-methyl-(9CI) (4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID >98% 1-Piperazineacetic acid, 4-Methyl- N-(Carboxymethyl)-N'-methylpiperazine (Carboxymethyl)-N'-methylpiperazine 2-(4-METHYLPIPERAZIN-1-YL)ACETIC ACID AKOS BB-5221 AKOS BBS-00002665 (4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID 4-METHYLPIPERAZINE-1-ACETIC ACID 4-METHYL PIPERAZINE-ACETIC ACID (4-METHYLPIPERAZINO)ACETIC ACID (4-METHYL-1-PIPERAZINYL)ACETIC ACID 4-METHYL-1-PIPERAZINE ACETIC ACID (4-Methylpiperazino)acetic acid 4-Methylpiperazine-1-acetic acid (4-Methyl-piperazin-1-yl)-aceticaci (4-Methyl-piperazin-1-yl)-acetic ac 4-Methyl-1-piperazin acetic acid 4-Methyl-1-piperazine acetic acid, 95% 54699-92-2 piperazines PIPERIDINE