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Icatibant Acetate

Icatibant Acetate structure

CAS No.: 138614-30-9

Chemical Name:: Icatibant Acetate

Synonyms: Firazyr;CS-1399;HOE 140 Acetate;Arteband Acetate;lcatibant Acetate;Aldeibant acetate;Etibatide acetate;Icatibant Acetate;HOE-140 (Icatibant);Etiban acetate salt

CBNumber:: CB5497052

Molecular Formula:: C59H89N19O13S.C2H4O2

Molecular Weight:: 1364.59

MDL Number:: MFCD04112967

MOL File:: 138614-30-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-08-04 11:17:55

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Icatibant Acetate Properties

storage temp.	-20°C
solubility	DMSO:65.0(Max Conc. mg/mL);47.63(Max Conc. mM) Ethanol:0.25(Max Conc. mg/mL);0.18(Max Conc. mM) PBS (pH 7.2):10.0(Max Conc. mg/mL);7.33(Max Conc. mM)
form	A crystalline solid
color	White to off-white
InChIKey	HKMZRZUEADSZDQ-SUJPMXFINA-N
FDA UNII	325O8467XK
UNSPSC Code	51111800
NACRES	NA.32

SAFETY

Risk and Safety Statements

PPE	Eyeshields, Gloves, type N95 (US)
WGK Germany	3
Storage Class	11 - Combustible Solids

Icatibant Acetate price More Price(56)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	H157	HOE 140 ≥94%	138614-30-9	250μg	$358	2026-04-30	Buy
Cayman Chemical	24083	Icatibant (acetate) ≥98%	138614-30-9	500μg	$90	2026-04-30	Buy
Cayman Chemical	24083	Icatibant (acetate) ≥98%	138614-30-9	1mg	$158	2026-04-30	Buy
Cayman Chemical	24083	Icatibant (acetate) ≥98%	138614-30-9	5mg	$479	2026-04-30	Buy
Usbiological	452174	Icatibant Acetate (HOE 140) ≥98%(HPLC,TLC)	138614-30-9	1mg	$472	2026-06-03	Buy

Product number	Packaging	Price	Buy
H157	250μg	$358	Buy
24083	500μg	$90	Buy
24083	1mg	$158	Buy
24083	5mg	$479	Buy
452174	1mg	$472	Buy

Icatibant Acetate Chemical Properties, Uses, Production

Description

Although it is a rare disease, HAE is an autosomal dominant disorder that can be potentially life-threatening when swelling manifests itself within the upper airways. Antagonism of the constitutively expressed B2 receptor, therefore, would not only be beneficial in the treatment of HAE but also find application in inflammatory, allergic, and hyperalgesic disorders.Designed to possess enhanced metabolic stability with the inclusion of five non-proteinogenic amino acids, icatibant is a competitive and selective B2 receptor antagonist (devoid of activity against the inducible B1 receptor) with a K_i of 2.2±0.7 nM, and it is the first downstream targeting agent to receive regulatory approval. It joins purified C1 esterase inhibitor, danazol (an attenuated androgen), and tranexamic acid (an antifibrinolytic agent) as acute and prophylactic treatments for HAE.

Originator

Jerini (Germany)

Uses

Antagonist (bradykinin).

Uses

Icatibant Acetate is a bradykinin B2 receptor antagonist that has been recently approved for treatment of acute attacks of hereditary angioedema (HAE).

Definition

ChEBI: An acetate salt obtained by combining icatibant with acetic acid. Used for the treatment of acute attacks of hereditary angioedema in adult patients.

brand name

Metastat (CollaGenex);Firazyr.

Biochem/physiol Actions

B2 bradykinin receptors are present in the sensory neurons. Activation of B2 receptor by bradykinin is associated with pro-inflammatory, pain producing and cardiovascular responses. HOE-140 is a selective B2 bradykinin receptor antagonist. Presence of HOE-140 suppresses the effects of bradykinin and has been shown to have anti-hyperalgesic response, particularly towards inflammatory pain.

Synthesis

The peptidomimetic is prepared by standard solidphase technology on Wang resin employing Fmoc chemistry. Following trifluoroacetic acid cleavage with appropriate scavengers and HPLC purification, icatibant is ultimately isolated as its acetate salt.

Icatibant Acetate Preparation Products And Raw materials

Raw materials

Preparation Products

Icatibant Acetate Suppliers

Global Suppliers ( 185)

Supplier	Tel	Email	Country	ProdList	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Adamas Reagent, Ltd.	4006009262 13023226327	hmj@titansci.com	China	14098	59
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4773	55
Wuxi Zhongkun Biochemical Technology Co., Ltd.	0510-85629785 18013409632;	sales@reading-chemicals.com	China	15165	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51389	80
Shanghai Haozhixiang Biotechnology Co., Ltd	526763801 13301653310	526763801@qq.com	China	7997	55
Avantpbc Chemical Tech(Shanghai) Co,Ltd.	17802107445		China	185	55
Shanghai YuanYe Biotechnology Co., Ltd.	18916372613	yanzihan@shyuanye.com	China	87240	60

Supplier	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	69
GL Biochem (Shanghai) Ltd	64
Adamas Reagent, Ltd.	59
Chemsky（shanghai）International Co.,Ltd.	50
Guangzhou Isun Pharmaceutical Co., Ltd	55
Wuxi Zhongkun Biochemical Technology Co., Ltd.	58
Sigma-Aldrich	80
Shanghai Haozhixiang Biotechnology Co., Ltd	55
Avantpbc Chemical Tech(Shanghai) Co,Ltd.	55
Shanghai YuanYe Biotechnology Co., Ltd.	60

View Latest Price from Icatibant Acetate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-10-13	HOE-140 138614-30-9	$1.00	1g	99%	100kg	RongNa Biotechnology Co.,Ltd
2026-10-13	HOE-140 138614-30-9		1g	98%min	1000g	WUHAN FORTUNA CHEMICAL CO., LTD
2026-09-29	Icatibant Acetate 138614-30-9		1g	>=99% (HPLC), USP43	10000000g	Chengdu Shengnuo Biopharm Co.,Ltd

HOE-140
138614-30-9
$1.00
99%
RongNa Biotechnology Co.,Ltd

HOE-140
138614-30-9
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Icatibant Acetate
138614-30-9
>=99% (HPLC), USP43
Chengdu Shengnuo Biopharm Co.,Ltd

Icatibant Acetate Spectrum

HOE-140(138614-30-9)MS

138614-30-9 (Icatibant Acetate) Related Search:

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Calcitonin salmon Icatibant Acetate Icatibant 1-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-amine H-Gly-Pro-Arg-OH acetate salt

H-Leu-Arg-OH N-Benzyl-1-(1-pyrrolidinyl)-2-propanamine

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HOE-140 (Icatibant) HOE140; ICATIBANT;HOE 140 CS-1399 Firazyr HOE 140 SYNTHETIC >99% SELECTIVE B2 BRAD YKIN d-arg-l-arg-l-pro-l-hyp-gly-l-(2-thienyl)ala-l-ser-d-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-l-(2α,3β,7aβ)-octahydro-1h-indole-2-carbonyl-l-arg Icatibant acetate, D-Arg-L-Arg-L-Pro-L-Hyp-Gly-L-(2-thienyl)Ala-L-Ser-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2α,3β,7aβ)-octahydro-1H-indole-2-carbonyl-L-Arg HOE 140 Acetate lcatibant Acetate (2S)-2-[[(3aS,7aS)-1-[2-[(2S)-2-[[(2S)-2-[[2-[[(4R)-1-[1-[2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]-4-hydroxy-pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-thiophen-2-yl-propanoyl]amino]-3-hydroxy-propanoyl]3,4-dihydro-1H-isoquinoline-3-carbonyl]2,3,3a,4,5,6,7,7a-octahydroindole-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid colitis,Bradykinin Receptor,inhibit,angiotensin,Icatibant Acetate,HOE140,ulcerative,Icatibant,HOE-140,Inhibitor,HOE 140 Aldeibant acetate H-D-Arg-Arg-Pro-Hyp-Gly-2Thi-Ser-DL-Tic-Oic-Arg-OH.CH3CO2H Icatibant Acetate, 10 mM in DMSO Etiban acetate salt Etibatide acetate Icatibant Acetate Arteband Acetate 138614-30-9 C59H89N19O13SxC2H4O2 C59H89N19O13S C59H90N20O12SC2H4O2n