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DMT-2'O-Methyl-rU Phosphoramidite

DMT-2'O-Methyl-rU Phosphoramidite structure

CAS No.: 110764-79-9

Chemical Name:: DMT-2'O-Methyl-rU Phosphoramidite

Synonyms: DMT-2'-O-Me-U-CE Phosphoramidite;2'-OMe-U amidite;2'-O-Me-5'-O-DMT-U-3'-CE-Phosphoramidite;2’-OMe -dU Amidite;5'-O-DMT-2'-OMe-U-CE;Cytidine Impurity 15;2'-OMe-Uridine Amidite;2'-OMe-U Phosphoramidite;2'-OMe-rU Phosphoramidite;2'-OMe-U-CE-Phosphoramidite

CBNumber:: CB5500323

Molecular Formula:: C40H49N4O9P

Molecular Weight:: 760.82

MDL Number:: MFCD00792626

MOL File:: 110764-79-9.mol

MSDS File:: SDS

Last updated:2026-01-13 11:17:27

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DMT-2'O-Methyl-rU Phosphoramidite Properties

storage temp.	Sealed in dry,2-8°C
solubility	DMSO : 100 mg/mL (131.44 mM; Need ultrasonic)
form	powder
pka	9.39±0.10(Predicted)
color	white to off-white
biological source	non-animal source (no BSE/TSE risk)
InChIKey	UVUOJOLPNDCIHL-XKZJCBTISA-N
SMILES	C(C1C=CC=CC=1)(C1C=CC(OC)=CC=1)(C1C=CC(OC)=CC=1)OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](OC)[C@@H]1OP(OCCC#N)N(C(C)C)C(C)C \|&1:25,27,36,39,r\|
UNSPSC Code	41116105
NACRES	NA.51

SAFETY

Risk and Safety Statements

WGK Germany	3
Storage Class	11 - Combustible Solids

DMT-2'O-Methyl-rU Phosphoramidite price More Price(66)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	U211180	DMT-2′O-Methyl-rU Phosphoramidite configured for PerkinElmer, configured for Polygen	110764-79-9	1G	$89.5	2026-04-30	Buy
Sigma-Aldrich	U211150	DMT-2′O-Methyl-rU Phosphoramidite configured for ?KTA? and OligoPilot?	110764-79-9	2g	$149.25	2026-04-30	Buy
Sigma-Aldrich	U211140	DMT-2′O-Methyl-rU Phosphoramidite configured for MerMade	110764-79-9	5 g	$74.3	2026-04-30	Buy
Sigma-Aldrich	U211140	DMT-2′O-Methyl-rU Phosphoramidite configured for MerMade	110764-79-9	1 g	$111	2026-04-30	Buy
Sigma-Aldrich	U211140	DMT-2′O-Methyl-rU Phosphoramidite configured for MerMade	110764-79-9	10 g	$202	2026-04-30	Buy

Product number	Packaging	Price	Buy
U211180	1G	$89.5	Buy
U211150	2g	$149.25	Buy
U211140	5 g	$74.3	Buy
U211140	1 g	$111	Buy
U211140	10 g	$202	Buy

DMT-2'O-Methyl-rU Phosphoramidite Chemical Properties,Uses,Production

Characteristics

DMT-2′O-Methyl-rU Phosphoramidite belongs to the class of 2′O-Methyl RNA Phosphoramidites. Its key features include:
High yield of crude oligonucleotides Compatible with DNA synthesis;
Can be employed together with DNA or RNA phosphoramidites in the same synthesis to produce mixmer oligonucleotides;
Recommended deprotection conditions are 8 hours at 55°C using concentrated ammonia solution, or with AMA (concentrated ammonia/40% aqueous methylamine I/I, v/v) for 10 minutes at 65°C;
Purification and other downstream processing of fully modified 2′OMethyl RNA oligonucleotides are simpler than in the case of RNA, as no special precautions are required to provide protection against nucleolytic degradation;
Synthesis of 2′O-Methyl RNA oligonucleotides is similar to standard DNA synthesis but requires an elongated coupling time (recommended is 6minutes compared to 90 seconds for DNA monomers);
2′O-Methyl RNA phosphoramidites are also available with fast deprotection chemistry.

Uses

DMT-2'O-Methyl-rU Phosphoramidite is a white to off-white powder and is used as a pharmaceutical intermediate for pharmaceutical synthesis and scientific research.

Application

2′O-Methyl RNA nucleoside including DMT-2′O-Methyl-rU Phosphoramidite can be advantageously incorporated in nucleic acid probes with RNA or DNA for in-vivo or in-vitro applications to convey nuclease resistance.The unique combination of properties of 2′O-Methyl RNA had found widespread use in the fields of:
Diagnostic probes
Aptamer and ribozyme development
Mixed 2′O-Methyl-RNA/DNA antisense molecules

DMT-2'O-Methyl-rU Phosphoramidite synthesis

Synthesis of DMT-2'O-Methyl-rU Phosphoramidite from 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite and 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyluridine

DMT-2'O-Methyl-rU Phosphoramidite Preparation Products And Raw materials

Raw materials

5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyluridine 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite

Preparation Products

DMT-2'O-Methyl-rU Phosphoramidite Suppliers

Global( 210)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhu Huaren Science and Technology Co., Ltd.	5842013 18155347026	xujuan@hdpharm.com	China	255	64
Hefei Shitong Biotechnology Co., Ltd.	15555170917	sales@stongbio.com	China	515	58
Nugene Biopharm Science (Hangzhou) Co., Ltd.	13326014885	service@nugene.com.cn	China	56	58
Tianjin Orilife Biopharma Co.,Ltd.	18522633659 17602299400	fengyiran@cnorilife.com	China	188	58
Wuhan Tangzhi Pharmaceutical Co., Ltd.	027-63498076 13658392159	sale@glycogene.com	China	838	58
Zhejiang Tianmei Bioengineering Co., Ltd.	18957127338 15336502278	3007630027@qq.com	China	1556	58
Hongene Biotech Corporation	021-64757213	info@hongene.com	China	672	61
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59

Supplier	Advantage
Wuhu Huaren Science and Technology Co., Ltd.	64
Hefei Shitong Biotechnology Co., Ltd.	58
Nugene Biopharm Science (Hangzhou) Co., Ltd.	58
Tianjin Orilife Biopharma Co.,Ltd.	58
Wuhan Tangzhi Pharmaceutical Co., Ltd.	58
Zhejiang Tianmei Bioengineering Co., Ltd.	58
Hongene Biotech Corporation	61
Beijing Ouhe Technology Co., Ltd	60
Jia Xing Isenchem Co.,Ltd	66
Adamas Reagent, Ltd.	59

View Lastest Price from DMT-2'O-Methyl-rU Phosphoramidite manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-04	5'-O-(4,4-Dimethoxytrityl)-2'-O-methyluridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite 110764-79-9		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2024-08-08	5'-O-DMT-2'-OMe-U-CE 110764-79-9		100mg	≥98%	20tons	Hefei Huana Biomedical Technology Co.,Ltd.
2024-02-13	5'-O-DMT-2'-O-methyluridine 3'-CE phosphoramidite 110764-79-9	$600.00	1g	98	500 Kg	R&D Scientific Inc.

5'-O-(4,4-Dimethoxytrityl)-2'-O-methyluridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
110764-79-9
98%
Henan Aochuang Chemical Co.,Ltd.

5'-O-DMT-2'-OMe-U-CE
110764-79-9
$0.00
≥98%
Hefei Huana Biomedical Technology Co.,Ltd.

5'-O-DMT-2'-O-methyluridine 3'-CE phosphoramidite
110764-79-9
$600.00
98
R&D Scientific Inc.

DMT-2'O-Methyl-rU Phosphoramidite Spectrum

DMT-2'O-Methyl-rU Phosphoramidite(110764-79-9)¹HNMR DMT-2'O-Methyl-rU Phosphoramidite(110764-79-9)³¹PNMR

110764-79-9(DMT-2'O-Methyl-rU Phosphoramidite)Related Search:

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L-Uridine Uridine 2'-O-Methyluridine DMT-dT Phosphoramidite N-blocked-5'-O-DMT 3'-CED iododeoxyuridine phosphoramidite

2'-O-Methyl-5-methyl-U CEP Fluorescein-dT CEP 5-[E-2-[N-[N-[N1-(4-t-Butylbenzoyl)-D-(+)-biotinyl]-6-aminohexyl]carboxamido]vinyl]-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite

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3-({[(2-{[BIS(4-METHOXYPHENYL)(PHENYL)METHOXY]METHYL}-5-(2,4-DIOXO-3H-PYRIMIDIN-1-YL)-4-METHOXYOXOLA DMT-2'O-ME-RU AMIDITE 0.5G 89 SINGLE 2'-O-methyluridine-ce phosphoramidite*for abi DMT-2'O-Me-rU Amidite 10g, Single DMT-2'O-ME-RU AMIDITE 0.5G AB SINGLE 2’-O-Methy-rUPhosphoramidite N-blocked-5'-O-DMT-2'-O-Me CED uridine phosphoramidite 5'-O-(4,4-Dimethoxytrityl)-2'-O-methyluridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite 5'-O-DMT-2'-O-Me-rU-3'-CEDPA 5'-O-DMT-2'-O-methyluridine 3'-CE phosphoramidite Uridine, 5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-O-Methyl-, 3'-[2-cyanoethyl bis(1-Methylethyl)phosphoraMidite] DMT-2′O-Methyl-rU Phosphoramidite 2'-O-Methyl-rU phosphoramidite 5'-DMT-2'-OMe-rU Phosphoramidite 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyluridine 3'-O-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyluridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidit 5'-O-(4, 4'-Dimethoxytrityl)-2'-O-methyl-Uridine-3'-CE-Phosphoramidite Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] 5'-Dimethoxytrityl-Uridine,2'-O-methyl,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite 5'-DMTr-2'-O-Me-3'-O-CEP-URIDINE 5'-O-DMT-2'-OMe-rU Phosphoramidite 5'-O-DMT-2'-OMe-Uridine-CE Phosphoramidite DMT-2-O-ME-U-CE Phosphoramidite DMT-2'-O-Me-U Phosphoramidite 5'-O-DMT-2'-OMe-U-CE 5'-O-DMT-2'-OMe- Uridine -3’-Cyanoethyl Phosphoramidite 2'-OMe-Uridine Amidite DMTr-2'-O-Me-rU-3'-CE-Phosphoramidite 2’-OMe -dU Amidite 5'-ODMT-2'-OMe Uridine-3'-OCEPA DMT-2'O-Methyl-rU Phosphoramidite 2'-OMe-U Phosphoramidite 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-methoxy-tetrahydrofuran-3-yl]oxy-(diisopropylamino)phosphanyl]oxypropanenitrile 2'-OMe-U-CE-Phosphoramidite 2'-O-Methyl Uridine CED Phosphoramidite 2'-OMe-rU Phosphoramidite 2'-Deoxy-2'-O-Me-5'-O-DMT-Uridine-3'-CED Phosphoramidite 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyluridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite Cytidine Impurity 15 5’-O-DMT-2’- OCH 3 -U-CE- Phosphoramidite 2'-O-Methyl Uridine CED Phosphoramidite 5'-O-DMT-2'-OMe-U-CE, 99%, ≤0.2%(K.F.) DMT-2'-0Me-U-CE-Phosphoramidite 5'-O-DMT-2' -O-methyluridine-3'-O-[O-(2-cyanoethyl)-N, N' -diisopropylphosphoramidite, Me-rU Phosphoramidite, 5'-o-[Bis(4-methoxy-phenyl)phenylmethyl]-2'-o-methyl-uridine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] 2’-O-MeU-3’-phosphoramidite 5’-O-DMTr-2’-O-methyluridine-3’-CED-Phosphoramidite 2'-OMe-U-3'-CE-phosphoramidite 2'-OMe-U amidite 2'-O-Me-5'-O-DMT-U-3'-CE-Phosphoramidite DMT-2'-O-Me-U-CE Phosphoramidite 2'-OMe-U phosphorus amide monomer 110764-79-9