DMT-2'O-Methyl-rU Phosphoramidite
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DMT-2'O-Methyl-rU Phosphoramidite 속성
- 저장 조건
- Sealed in dry,2-8°C
- 용해도
- DMSO : 100 mg/mL (131.44 mM; Need ultrasonic)
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 9.39±0.10(Predicted)
- 색상
- 흰색에서 황백색까지
- 생물학적 소스
- non-animal source (no BSE/TSE risk)
- InChIKey
- UVUOJOLPNDCIHL-XKZJCBTISA-N
- SMILES
- C(C1C=CC=CC=1)(C1C=CC(OC)=CC=1)(C1C=CC(OC)=CC=1)OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](OC)[C@@H]1OP(OCCC#N)N(C(C)C)C(C)C |&1:25,27,36,39,r|
안전
| WGK 독일 | 3 |
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DMT-2'O-Methyl-rU Phosphoramidite C화학적 특성, 용도, 생산
Characteristics
DMT-2′O-Methyl-rU Phosphoramidite belongs to the class of 2′O-Methyl RNA Phosphoramidites. Its key features include:High yield of crude oligonucleotides Compatible with DNA synthesis;
Can be employed together with DNA or RNA phosphoramidites in the same synthesis to produce mixmer oligonucleotides;
Recommended deprotection conditions are 8 hours at 55 deg C using concentrated ammonia solution, or with AMA (concentrated ammonia/40% aqueous methylamine I/I, v/v) for 10 minutes at 65 deg C;
Purification and other downstream processing of fully modified 2′OMethyl RNA oligonucleotides are simpler than in the case of RNA, as no special precautions are required to provide protection against nucleolytic degradation;
Synthesis of 2′O-Methyl RNA oligonucleotides is similar to standard DNA synthesis but requires an elongated coupling time (recommended is 6minutes compared to 90 seconds for DNA monomers);
2′O-Methyl RNA phosphoramidites are also available with fast deprotection chemistry.
용도
DMT-2'O-Methyl-rU Phosphoramidite is a white to off-white powder and is used as a pharmaceutical intermediate for pharmaceutical synthesis and scientific research.주요 응용
2′O-Methyl RNA nucleoside including DMT-2′O-Methyl-rU Phosphoramidite can be advantageously incorporated in nucleic acid probes with RNA or DNA for in-vivo or in-vitro applications to convey nuclease resistance.The unique combination of properties of 2′O-Methyl RNA had found widespread use in the fields of:Diagnostic probes
Aptamer and ribozyme development
Mixed 2′O-Methyl-RNA/DNA antisense molecules
DMT-2'O-Methyl-rU Phosphoramidite 준비 용품 및 원자재
원자재
5'-O-(4,4'-DIMETHOXYTRITYL)-2'-O-METHYLURIDINE
2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite
준비 용품
DMT-2'O-Methyl-rU Phosphoramidite 공급 업체
글로벌( 190)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Wuhu Nuowei chemistry Co., Ltd. | +86-0553-2911116-802 +86-18055311600 |
sales1@nuowei-chem.com | China | 1627 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 |
info@dakenam.com | China | 12930 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29855 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10406 | 58 |
| Yunbio Tech Co.,Ltd. | +86-010-60605551 +86-18046518538 |
yunbiochem@126.com | China | 321 | 58 |
| Nanjing Baifuli Technology Co., Ltd. | +86-15335185688 |
sales@unisyn.cn | CHINA | 332 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19552 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49975 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 |
contact@trustwe.com | China | 5744 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 |
eric@witopchemical.com | China | 23541 | 58 |
DMT-2'O-Methyl-rU Phosphoramidite 관련 검색:
(3-클로로프로필)트리메톡시실란 프로필트리메톡시실란 3- 머 캅토 프로필 트리에 톡시 실란 N,N-다이아이소프로필에틸아민 우리딘 5'-디메톡시트리틸-3'-데옥시티미딘2'-[(2-시아노에틸)-(N,N-디이소프로필)]-포스포르아미다이트 형광물질-DTCEP N-차단된-5'-O-DMT3'-CED요오도데옥시우리딘포스포르아미다이트 2'-O-메틸-5-메틸-UCEP 5'-DMT-5-BROMO-DU포스포라미다이트(키랄) 5-하이드록시-DUCEP 아미노-개량제-C2-DTCEP
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