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1-(Chloromethyl)-3,5-bis(methylsulfonyl)benzene

1-(Chloromethyl)-3,5-bis(methylsulfonyl)benzene Structure
1-(Chloromethyl)-3,5-bis(methylsulfonyl)benzene structure
CAS No.
39552-81-3
Chemical Name:
1-(Chloromethyl)-3,5-bis(methylsulfonyl)benzene
Synonyms
2-(4-aminophenyl)propanoate;Benzocaine Impurity 14;METHYL P-AMINOPHENYLACETATE;Methyl 4-aminobenzeneacetate;METHYL-(4-AMINOPHENYL)ACETATE;p-(Methoxycarbonylmethyl)aniline;4-Aminophenylacetic acid methyl ester;Benzeneacetic acid, 4-amino-, methyl ester;1-(Chloromethyl)-3,5-bis(methylsulfonyl)benzene;1-(CHLOROMETHYL)-3,5-BIS(METHYLSULPHONYL)BENZENE
CBNumber:
CB5672534
Molecular Formula:
C9H11NO2
Molecular Weight:
165.19
MDL Number:
MFCD06200783
MOL File:
39552-81-3.mol
Last updated:2026-09-12 18:53:38
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1-(Chloromethyl)-3,5-bis(methylsulfonyl)benzene Properties

Melting point 197-200°C
Boiling point 96-100/0.07mm
Density 1.143±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
pka 4.36±0.10(Predicted)
form liquid
color Brown
InChI 1S/C9H11NO2/c1-12-9(11)6-7-2-4-8(10)5-3-7/h2-5H,6,10H2,1H3
InChIKey TVIVLENJTXGRAM-UHFFFAOYSA-N
SMILES COC(=O)Cc1ccc(N)cc1
UNSPSC Code 12352200
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard Codes  Xi
Risk Statements  43-52
Safety Statements  36-37
WGK Germany  WGK 3
HazardClass  IRRITANT
HS Code  2922290090
Storage Class 11 - Combustible Solids

1-(Chloromethyl)-3,5-bis(methylsulfonyl)benzene price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR0171 Methyl 4-aminophenylacetate 98% 39552-81-3 1g $21 2026-06-04 Buy
Apolloscientific OR0171 Methyl 4-aminophenylacetate 98% 39552-81-3 5g $24 2026-06-04 Buy
Matrix Scientific 012593 Methyl-(4-aminophenyl)acetate 39552-81-3 25.00g $38 2026-05-18 Buy
Matrix Scientific 012593 Methyl-(4-aminophenyl)acetate 39552-81-3 100.00g $123 2026-05-18 Buy
Matrix Scientific 012593 Methyl-(4-aminophenyl)acetate 39552-81-3 500.00g $606 2026-05-18 Buy
Product number Packaging Price Buy
OR0171 1g $21 Buy
OR0171 5g $24 Buy
012593 25.00g $38 Buy
012593 100.00g $123 Buy
012593 500.00g $606 Buy

1-(Chloromethyl)-3,5-bis(methylsulfonyl)benzene Chemical Properties, Uses, Production

Synthesis

Methanol

67-56-1

4-Aminophenylacetic acid

1197-55-3

1-(CHLOROMETHYL)-3,5-BIS(METHYLSULFONYL)BENZENE

39552-81-3

Synthesis of Intermediate 8a: Methyl 2-(4-aminophenyl)acetate 4-Aminophenylacetic acid (10.0 g, 66.6 mmol) was dissolved in methanol (350 mL), stirred and concentrated. Concentrated sulfuric acid (3.88 mL, 72.77 mmol) was added slowly and dropwise. The reaction mixture was stirred at 50 °C overnight and subsequently cooled to room temperature and concentrated under vacuum. The concentrated mixture was diluted with water, neutralized with sodium carbonate (Na2CO3) until the solid precipitated, and then extracted with dichloromethane (DCM). The organic layer was dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated to give methyl 2-(4-aminophenyl)acetate (9.75 g, 59.02 mmol, 89% yield). Method 2: RT: 0.60 min, m/z 165.9 [M + H]+.

References

[1] Patent: US2014/303218, 2014, A1. Location in patent: Paragraph 0088-0089
[2] Dalton Transactions, 2018, vol. 47, # 15, p. 5259 - 5268
[3] Patent: WO2016/51193, 2016, A1. Location in patent: Paragraph 00249; 00250; 00251
[4] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 6, p. 1784 - 1789
[5] Journal of Medicinal Chemistry, 1997, vol. 40, # 7, p. 1049 - 1062

1-(Chloromethyl)-3,5-bis(methylsulfonyl)benzene synthesis

1197-55-3
39552-81-3
Synthesis of 1-(Chloromethyl)-3,5-bis(methylsulfonyl)benzene from 4-Aminophenylacetic acid

1-(Chloromethyl)-3,5-bis(methylsulfonyl)benzene Preparation Products And Raw materials

Raw materials

ASISCHEM D29204 (4-Amino-phenyl)-acetic acid methyl ester HCl Methyl p-nitrophenylacetate 4-Aminophenylacetonitrile 4-Nitrophenylacetic acid
Methanol (Trimethylsilyl)diazomethane p-Nitrophenylacetonitrile 4-Aminophenylacetic acid Benzeneacetonitrile

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Preparation Products

Methyl 2-(4-aMino-3-iodophenyl)acetate

1-(Chloromethyl)-3,5-bis(methylsulfonyl)benzene Suppliers

Global Suppliers ( 93)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Clearsynth Labs Limited +91-22-26355700 info@clearsynth.com India 9656 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Wuxi Zhongkun Biochemical Technology Co., Ltd. 0510-85629785 18013409632; sales@reading-chemicals.com China 15165 58
Hangzhou J&H Chemical Co., Ltd. 0571-87396432 sales@jhechem.com China 14905 59
Cool Pharm, Ltd 021-60455363 18019463053 sales@coolpharm.com China 8455 58
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64
Accela ChemBio Co.,Ltd. 64
Clearsynth Labs Limited 58
Bide Pharmatech Ltd. 60
Wuxi Zhongkun Biochemical Technology Co., Ltd. 58
Hangzhou J&H Chemical Co., Ltd. 59
Cool Pharm, Ltd 58

View Latest Price from 1-(Chloromethyl)-3,5-bis(methylsulfonyl)benzene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
39552-81-3 pictures 2020-01-08 39552-81-3
39552-81-3
 1KG 98%; 99% 1kg; 10kg; 25kg Career Henan Chemical Co
  • 39552-81-3 pictures
  • 39552-81-3
    39552-81-3
  • $0.01
  • 98%; 99%
  • Career Henan Chemical Co

1-(Chloromethyl)-3,5-bis(methylsulfonyl)benzene Spectrum

1-(CHLOROMETHYL)-3,5-BIS(METHYLSULFONYL)BENZENE(39552-81-3)1HNMR

39552-81-3 (1-(Chloromethyl)-3,5-bis(methylsulfonyl)benzene) Related Search:

4-Aminophenylacetonitrile 4-Aminophenylacetic acid Methyl α-methyl-p-aminophenylacetate Ethyl 4-nitrophenylacetate 7-Diethylamino-3-(4'-maleimidylphenyl)-4- methylcoumarin
Vincristine sulfate Ethyl 4-aminophenylacetate Ethyl 4-nitrophenylglyoxylate Methyl 2,4-dinitrophenylacetate Bis(2,4-dinitrophenyl)acetic acid ethyl ester
Methyl p-nitrophenylacetate Ethyl 2-(4-amino-3-methoxyphenyl)-3,3,3-trifluoro-2-hydroxypropanoate 3-(4-Amino-phenyl)-chromen-2-one 5-[(Dimethylamino)methylene]-4-methyl-3-(4-nitrophenyl)-2(5H)-furanone 2-Oxopropyl 2-(4-nitrophenyl)acetate
Ethyl 2-(4-[(2-chloroacetyl)(methyl)amino]phenyl)-3,3,3-trifluoro-2-hydroxypropanoate Methyl 2-(4-[(([(1-chloroethylidene)amino]oxy)carbonyl)(methyl)amino]phenyl)-3,3,3-trifluoro-2-hydroxypropanoate 3,3,3-Trifluoro-2-hydroxy-2-(4-methylamino-phenyl)-propionic acid ethyl ester

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METHYL P-AMINOPHENYLACETATE METHYL-(4-AMINOPHENYL)ACETATE 1-(CHLOROMETHYL)-3,5-BIS(METHYLSULPHONYL)BENZENE Benzeneacetic acid, 4-amino-, methyl ester p-(Methoxycarbonylmethyl)aniline 4-Aminophenylacetic acid methyl ester Methyl 4-aminobenzeneacetate 4-Aminophenylacetic acid methyl ester, 4-[(Methoxycarbonyl)methyl]aniline 2-(4-aminophenyl)propanoate Benzocaine Impurity 14 1-(Chloromethyl)-3,5-bis(methylsulfonyl)benzene 39552-81-3 Aromatic Esters