R-tetrahydropapaverine HCl
- CAS No.
- 54417-53-7
- Chemical Name:
- R-tetrahydropapaverine HCl
- Synonyms
- R-BINAP;(1R)-1-[(3,4-diMethoxyphenyl)Methyl]-6,7-diMethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride;R-Tetrahydropapaverine;R-(+)-Tetrahydropapaverin;R-tetrahydropapaverine HC;R-tetrahydropapaverine HCl;R-TATRAHYDROPAPAVERINE HCL;Atracurium Besylate Impurity 7;D-(-)-Norlaudanosine hydrochloride;Cisatracurium Besilate Impurity 19
- CBNumber:
- CB5718052
- Molecular Formula:
- C20H26ClNO4
- Molecular Weight:
- 379.88
- MDL Number:
- MFCD09750421
- MOL File:
- 54417-53-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 475.8℃ |
|---|---|
| Density | 1.32 at 22℃ |
| vapor pressure | 0Pa at 25℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1/C20H25NO4.ClH/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16;/h5-6,10-12,16,21H,7-9H2,1-4H3;1H/t16-;/s3 |
| InChIKey | VMPLLPIDRGXFTQ-LSQUZMQTNA-N |
| SMILES | C(C1C=CC(OC)=C(OC)C=1)[C@H]1NCCC2=CC(OC)=C(OC)C=C12.Cl |&1:11,r| |
| LogP | -0.63 at 25℃ |
| CAS DataBase Reference | 54417-53-7(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
R-tetrahydropapaverine HCl price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-N661415-500MG | (R)-(-)-Norlaudanosine Hydrochloride | 54417-53-7 | 500mg | $103 | 2026-06-03 | Buy |
| TRC | TRC-N661415-2.5G | (R)-(-)-Norlaudanosine Hydrochloride | 54417-53-7 | 2.5g | $165 | 2026-06-03 | Buy |
| TRC | TRC-N661415-100MG | (R)-(-)-Norlaudanosine Hydrochloride | 54417-53-7 | 100mg | $65 | 2026-06-03 | Buy |
| AstaTech | 60200 | (R)-1-(3,4-DIMETHOXY-BENZYL)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE 97% | 54417-53-7 | 1G | $20 | 2026-04-30 | Buy |
| AstaTech | 60200 | (R)-1-(3,4-DIMETHOXY-BENZYL)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE 97% | 54417-53-7 | 5G | $30 | 2026-04-30 | Buy |
R-tetrahydropapaverine HCl Chemical Properties,Uses,Production
Application
R-tetrahydropapaverine HCl is a useful research chemical.
Synthesis
6429-04-5
54417-53-7
The general procedure for the synthesis of the target compound using 1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride as raw material was as follows: 20 g of 1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride was dissolved in 400 mL of distilled water, and stirred until completely dissolved. Subsequently, ammonia was added to the solution to adjust the pH, and after observing that no white oily material precipitated, 400 mL of toluene was added and mixed with thorough stirring. The organic phase (toluene layer) and the aqueous phase were separated to ensure that there was no residual raw material in the aqueous phase. The organic phase was dried with anhydrous sodium sulfate to obtain 17.3 g of racemate. The racemate was dissolved in 173 mL of acetonitrile and heated to 70 °C. 3.93 g of the splitting agent N-acetyl-D-leucine was slowly added and the reaction was stirred for 20 minutes. Next, 0.522 g of the splitting agent N-acetyl-D-phenylalanine was added and the reaction was continued with stirring for 35 minutes. Upon completion of the reaction, it was slowly cooled to room temperature and subsequently stored in a refrigerator at 4°C for 24 hours to promote crystallization. Upon completion of crystallization, the solid product was collected by filtration. The product was converted to hydrochloride form, treated by adding appropriate amount of hydrochloric acid and dried to give 8.325 g of 1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride in R-configuration. The total yield was 83.25% and the purity was 97.6%.
References
[1] Patent: CN107056700, 2017, A. Location in patent: Paragraph 0040-0043; 0046; 0058
R-tetrahydropapaverine HCl Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Lianyungang Shenghe Biotechnology Co., Ltd. | 0518-87108777 13585296001 | haizaofu@163.com | China | 44 | 58 |
| Sichuan Mingjian Pharmaceutical Chemical Co., Ltd. | 15281098982 | sales@mjpharma.cn | China | 57 | 58 |
| TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD. | 022-60189726 18812034280 | 188120342808@163.com | China | 143 | 61 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
View Lastest Price from R-tetrahydropapaverine HCl manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-07 | R-tetrahydropapaverine HCl
54417-53-7
|
1KG | 99% | 1KG 10KG 100KG | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2026-06-30 | R-tetrahydropapaverine HCl
54417-53-7
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2024-05-07 | R-tetrahydropapaverine HCl
54417-53-7
|
$890.00 | 1Kg | 98 | 500 Kg | R&D Scientific Inc. |
-
- R-tetrahydropapaverine HCl
54417-53-7
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- R-tetrahydropapaverine HCl
54417-53-7
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- R-tetrahydropapaverine HCl
54417-53-7
- $890.00
- 98
- R&D Scientific Inc.
54417-53-7(R-tetrahydropapaverine HCl)Related Search:
1of4
