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(+)-PHYLLODULCIN

(+)-PHYLLODULCIN Structure
(+)-PHYLLODULCIN structure
CAS No.
21499-23-0
Chemical Name:
(+)-PHYLLODULCIN
Synonyms
PHYLLODULCIN;PHYLLODUCIN;Praeruptorin;(+)-PHYLLODULCIN;(+)-Praeruptorin;(+)-PHYLLODULCIN;(3R)-Phyllodulcin;R-(+)-Phyllodulcin;(+)-PHYLLODULCIN USP/EP/BP;(R)-8-Hydroxy-3-(3-Hydroxy-4-Methoxyphenyl)Isochroman-1-One
CBNumber:
CB5764271
Molecular Formula:
C16H14O5
Molecular Weight:
286.28
MDL Number:
MFCD00210357
MOL File:
21499-23-0.mol
MSDS File:
SDS
Last updated:2026-01-13 11:23:05
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(+)-PHYLLODULCIN Properties

solubility DMSO: 2 mg/mL, clear
form Solid
color White to off-white
SMILES O=C1C2=C(O)C=CC=C2C[C@H](C3=CC(O)=C(C=C3)OC)O1
FDA UNII 9DDW04R41V
NACRES NA.21

(+)-PHYLLODULCIN price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth FP137823 (+)-Phyllodulcin 21499-23-0 1g $8250 2026-06-04 Buy
ChemScene CS-0037528 Phyllodulcin ≥95% 21499-23-0 50mg $1015 2026-06-04 Buy
ChemScene CS-0037528 Phyllodulcin ≥95% 21499-23-0 100mg $2030 2026-06-04 Buy
aablocks AA00BD1R (3R)-3,4-Dihydro-8-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-1H-2-benzopyran-1-one 95% 21499-23-0 5mg $579 2026-05-28 Buy
aablocks AA00BD1R (3R)-3,4-Dihydro-8-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-1H-2-benzopyran-1-one 95% 21499-23-0 10mg $757 2026-05-28 Buy
Product number Packaging Price Buy
FP137823 1g $8250 Buy
CS-0037528 50mg $1015 Buy
CS-0037528 100mg $2030 Buy
AA00BD1R 5mg $579 Buy
AA00BD1R 10mg $757 Buy

(+)-PHYLLODULCIN Chemical Properties,Uses,Production

Uses

Phyllodulcin is an orally active sweetener found in Hydrangea macrophylla var. thunbergii. Phyllodulcin acts as a non-selective phosphodiesterase inhibitor and exerts anti-allergic effects by suppressing lymphocyte activation. Phyllodulcin can be used to combat obesity by regulating levels of leptin, fat browning-related genes, and hypothalamic BDNF-TrkB signaling[1][2].

Definition

ChEBI: Phyllodulcin is a hydroxybenzoic acid.

References

[1] Liu J, et al. Medicinal flowers. XXXX . Structures of dihydroisocoumarin glycosides and inhibitory effects on aldose reducatase from the flowers of Hydrangea macrophylla var.thunbergii. Chem Pharm Bull (Tokyo). 2013;61(6):655-61. DOI:10.1248/cpb.c13-00160
[2] Kim E, et al. Phyllodulcin, a Natural Sweetener, Regulates Obesity-Related Metabolic Changes and Fat Browning-Related Genes of Subcutaneous White Adipose Tissue in High-Fat Diet-Induced Obese Mice. Nutrients. 2017 Sep 21;9(10):1049. DOI:10.3390/nu9101049

(+)-PHYLLODULCIN synthesis

946002-05-7
21499-23-0
Synthesis of (+)-PHYLLODULCIN from 1H-2-Benzopyran-1-one, 3,4-dihydro-8-hydroxy-3-[4-methoxy-3-(methoxymethoxy)phenyl]-, (3R)-

(+)-PHYLLODULCIN Preparation Products And Raw materials

Raw materials

1H-2-Benzopyran-1-one, 3,4-dihydro-8-hydroxy-3-[4-methoxy-3-(methoxymethoxy)phenyl]-, (3R)- 2-Oxabicyclo[2.2.1]heptane-1-carboxylic acid, 4,7,7-trimethyl-3-oxo-, 3,4-dihydro-3-(3-hydroxy-4-methoxyphenyl)-1-oxo-1H-2-benzopyran-8-yl ester, [1R-[1α(R*),4β]]- (9CI)

Preparation Products

(+)-PHYLLODULCIN Suppliers

Global( 35)Suppliers
Supplier Tel Email Country ProdList Advantage
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7717 56
Finetech Industry Limited 027-87465837 19945049750 sales@finetechnology-ind.com China 9331 58
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Wuxi AppTec 022-59987777 13552403979 jia_guoqiang@wuxiapptec.com China 22344 58
Aikon International Limited 025-66113011 19370895928 qzhang@aikonchem.com China 15390 58
Twochem Co.Ltd. 021-58111628 15800915896 sales@twochem.com China 1782 58
Tianjin Kaifu Pharmaceutical Technology Co., Ltd. 18081075745 chemflowtech@sina.com China 1883 58
Dideu Industries Group Limited +8617392712697 1022@dideu.com China 29091 58
BOC Sciences +1-631-485-4226 inquiry@bocsci.com United States 19935 58
Wuhan Topule +86-02787215551 19945035818 2936752263@qq.com China 7985 58
Supplier Advantage
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
Finetech Industry Limited 58
ShangHai Biochempartner Co.,Ltd 62
Wuxi AppTec 58
Aikon International Limited 58
Twochem Co.Ltd. 58
Tianjin Kaifu Pharmaceutical Technology Co., Ltd. 58
Dideu Industries Group Limited 58
BOC Sciences 58
Wuhan Topule 58

21499-23-0((+)-PHYLLODULCIN)Related Search:

Bletillae Rhizoma lycii Fructus Psoralen Angelicae Sinensis Radix Vaccariae Semen
Ophiopogonis Radix RADIX SCUTELLARIAE Forsythiae Fructus 2-Bibenzylcarboxylic acid Benzyl salicylate
Isopropyl salicylate 3,4-dihydro-1H-2-benzopyran-1-one (+)-PHYLLODULCIN hydrangenol 1H-2-Benzopyran-1-one, 3,4-dihydro-8-hydroxy-
6-Methylsalicylic acid ethyl ester 3-Phenyl-3,4-dihydroisocoumarin

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(3R)-3-(3-Hydroxy-4-methoxyphenyl)-8-hydroxyisochroman-1-one (3R)-3β-(3-Hydroxy-4-methoxyphenyl)-8-hydroxy-3,4-dihydro-1H-2-benzopyran-1-one (3R)-Phyllodulcin (R)-3,4-Dihydro-8-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-1H-2-benzopyran-1-one R-(+)-Phyllodulcin (+)-Praeruptorin Praeruptorin (R)-8-Hydroxy-3-(3-Hydroxy-4-Methoxyphenyl)Isochroman-1-One PHYLLODUCIN (+)-PHYLLODULCIN (R)-8-Hydroxy-3-(3-Hydroxy-4-Methoxyphenyl)Isochroman-1-One(WXC00795) 1H-2-Benzopyran-1-one, 3,4-dihydro-8-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-, (3R)- (+)-PHYLLODULCIN USP/EP/BP (3R)-8-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-3,4-dihydroisochromen-1-one (+)-PHYLLODULCIN PHYLLODULCIN 21499-23-0 Miscellaneous Natural Products