| Company Name: |
Wuxi AppTec |
| Tel: |
022-59987777 13552403979 |
| Email: |
jia_guoqiang@wuxiapptec.com |
|
| | (+)-PHYLLODULCIN Basic information |
| Product Name: | (+)-PHYLLODULCIN | | Synonyms: | (3R)-3-(3-Hydroxy-4-methoxyphenyl)-8-hydroxyisochroman-1-one;(3R)-3β-(3-Hydroxy-4-methoxyphenyl)-8-hydroxy-3,4-dihydro-1H-2-benzopyran-1-one;(3R)-Phyllodulcin;(R)-3,4-Dihydro-8-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-1H-2-benzopyran-1-one;R-(+)-Phyllodulcin;(+)-Praeruptorin;Praeruptorin;(R)-8-Hydroxy-3-(3-Hydroxy-4-Methoxyphenyl)Isochroman-1-One | | CAS: | 21499-23-0 | | MF: | C16H14O5 | | MW: | 286.28 | | EINECS: | | | Product Categories: | Miscellaneous Natural Products | | Mol File: | 21499-23-0.mol |  |
| | (+)-PHYLLODULCIN Chemical Properties |
| solubility | DMSO: 2 mg/mL, clear | | form | Solid | | color | White to off-white | | SMILES | O=C1C2=C(O)C=CC=C2C[C@H](C3=CC(O)=C(C=C3)OC)O1 |
| | (+)-PHYLLODULCIN Usage And Synthesis |
| Uses | Phyllodulcin is an orally active sweetener found in Hydrangea macrophylla var. thunbergii. Phyllodulcin acts as a non-selective phosphodiesterase inhibitor and exerts anti-allergic effects by suppressing lymphocyte activation. Phyllodulcin can be used to combat obesity by regulating levels of leptin, fat browning-related genes, and hypothalamic BDNF-TrkB signaling[1][2]. | | Definition | ChEBI: Phyllodulcin is a hydroxybenzoic acid. | | References | [1] Liu J, et al. Medicinal flowers. XXXX . Structures of dihydroisocoumarin glycosides and inhibitory effects on aldose reducatase from the flowers of Hydrangea macrophylla var.thunbergii. Chem Pharm Bull (Tokyo). 2013;61(6):655-61. DOI:10.1248/cpb.c13-00160
[2] Kim E, et al. Phyllodulcin, a Natural Sweetener, Regulates Obesity-Related Metabolic Changes and Fat Browning-Related Genes of Subcutaneous White Adipose Tissue in High-Fat Diet-Induced Obese Mice. Nutrients. 2017 Sep 21;9(10):1049. DOI:10.3390/nu9101049 |
| | (+)-PHYLLODULCIN Preparation Products And Raw materials |
| Raw materials | 1H-2-Benzopyran-1-one, 3,4-dihydro-8-hydroxy-3-[4-methoxy-3-(methoxymethoxy)phenyl]-, (3R)--->2-Oxabicyclo[2.2.1]heptane-1-carboxylic acid, 4,7,7-trimethyl-3-oxo-, 3,4-dihydro-3-(3-hydroxy-4-methoxyphenyl)-1-oxo-1H-2-benzopyran-8-yl ester, [1R-[1α(R*),4β]]- (9CI) |
|