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4-[[N-(Imidazol-4-yl)methyleneamino]-2-(1-naphthyl)benzoyl]leucine methyl ester

4-[[N-(Imidazol-4-yl)methyleneamino]-2-(1-naphthyl)benzoyl]leucine methyl ester structure

CAS No.: 191102-87-1

Chemical Name:: 4-[[N-(Imidazol-4-yl)methyleneamino]-2-(1-naphthyl)benzoyl]leucine methyl ester

Synonyms: GGTI-2147;GGTI-2147 (GGTI2147);TUQRZGWNDBXSNP-SANMLTNESA-N;Geranylgeranyl transferase inhibitor-2147;4-[[N-(Imidazol-4-yl)methyleneamino]-2-(1-naphthyl)benzoyl]leucine methyl ester;L-Leucine, N-[4-[(1H-imidazol-5-ylmethyl)amino]-2-(1-naphthalenyl)benzoyl]-, methyl ester

CBNumber:: CB5766770

Molecular Formula:: C28H30N4O3

Molecular Weight:: 470.56

MDL Number:: MFCD22581512

MOL File:: Mol file

MSDS File:: SDS

Last updated:2026-09-12 18:53:41

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4-[[N-(Imidazol-4-yl)methyleneamino]-2-(1-naphthyl)benzoyl]leucine methyl ester Properties

Boiling point	710.6±60.0 °C(Predicted)
Density	1.224±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO
pka	13.22±0.46(Predicted)
form	Solid
color	off-white
Sensitive	Light Sensitive & Hygroscopic
InChIKey	TUQRZGWNDBXSNP-SANMLTNESA-N
SMILES	[nH]1cnc(c1)CNc2cc(c(cc2)C(=O)N[C@@H](CC(C)C)C(=O)OC)c3c4c(ccc3)cccc4
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

WGK Germany	WGK 1
Storage Class	11 - Combustible Solids

4-[[N-(Imidazol-4-yl)methyleneamino]-2-(1-naphthyl)benzoyl]leucine methyl ester price More Price(14)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	345885	GGTI-2147 - CAS 191102-87-1 - Calbiochem A cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I).	191102-87-1	250μG	$270	2026-04-30	Buy
Usbiological	164284	GGTI-2147	191102-87-1	100ug	$403	2026-06-03	Buy
aablocks	AA00AB6T	GGTI 2147	191102-87-1	1mg	$270	2026-05-28	Buy
aablocks	AA00AB6T	GGTI 2147	191102-87-1	5mg	$582	2026-05-28	Buy
aablocks	AA00AB6T	GGTI 2147	191102-87-1	10mg	$755	2026-05-28	Buy

Product number	Packaging	Price	Buy
345885	250μG	$270	Buy
164284	100ug	$403	Buy
AA00AB6T	1mg	$270	Buy
AA00AB6T	5mg	$582	Buy
AA00AB6T	10mg	$755	Buy

4-[[N-(Imidazol-4-yl)methyleneamino]-2-(1-naphthyl)benzoyl]leucine methyl ester Chemical Properties, Uses, Production

Uses

GGTI-2147 is an inhibitors of protein geranylgeranyltransferase-I and protein prenylation. Increases prelamin A accumulation by inhibiting ZMPSTE24 protein in human fibroblast and increases cytosolic accumulation of Rac1 and elicites significant inhibition of GSIS from INS 832/13 cells.

Biological Activity

Cell permeable: yes', 'Primary Target
GGTase-I', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 500 nM in blocking the geranyl-geranylation of Rap1A

4-[[N-(Imidazol-4-yl)methyleneamino]-2-(1-naphthyl)benzoyl]leucine methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

4-[[N-(Imidazol-4-yl)methyleneamino]-2-(1-naphthyl)benzoyl]leucine methyl ester Suppliers

Global Suppliers ( 36)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64
Shanghai TaoSu Biochemical Technology Co., Ltd.	021-33632979	info@tsbiochem.com	China	8039	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9799	58
Alabiotech Inc.	001-619-354-5251	sales@alabiotech-e.com	United States	972	60
Alpha Biopharmaceuticals Co., Ltd	0411-39042497	sales@alphabiopharm.com	China	1951	58
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226	sales@rrkchem.com	China	57336	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19904	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44871	58

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
VDM Biochemicals	64
Shanghai TaoSu Biochemical Technology Co., Ltd.	58
Shanghai EFE Biological Technology Co., Ltd.	58
Alabiotech Inc.	60
Alpha Biopharmaceuticals Co., Ltd	58
Shenzhen Polymeri Biochemical Technology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Nextpeptide Inc	58
Energy Chemical	58

View Latest Price from 4-[[N-(Imidazol-4-yl)methyleneamino]-2-(1-naphthyl)benzoyl]leucine methyl ester manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-03	GGTI 2147 191102-87-1	$312.00-918.00		98.69%	10g	TargetMol Chemicals Inc.

GGTI 2147
191102-87-1
$312.00-918.00
98.69%
TargetMol Chemicals Inc.

4-[[N-(Imidazol-4-yl)methyleneamino]-2-(1-naphthyl)benzoyl]leucine methyl ester Spectrum

4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER(191102-87-1)¹HNMR

191102-87-1 (4-[[N-(Imidazol-4-yl)methyleneamino]-2-(1-naphthyl)benzoyl]leucine methyl ester) Related Search:

GGTI 2133 (trifluoroacetate salt) GGTI-2154 hydrochloride GGTI-2166 4-[[N-(Imidazol-4-yl)methyleneamino]-2-(1-naphthyl)benzoyl]leucine methyl ester GGTI-2154

FTI-2153

1of2

GGTI-2147 TUQRZGWNDBXSNP-SANMLTNESA-N GGTI-2147 (GGTI2147) L-Leucine, N-[4-[(1H-imidazol-5-ylmethyl)amino]-2-(1-naphthalenyl)benzoyl]-, methyl ester Geranylgeranyl transferase inhibitor-2147 4-[[N-(Imidazol-4-yl)methyleneamino]-2-(1-naphthyl)benzoyl]leucine methyl ester 191102-87-1 A cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I). Amino Acids & Derivatives, Chiral Reagents, Heterocycles, Inhibitors Other enzyme inhibitors and activators