3-N-Boc-aminopyrrolidine
- CAS No.
- 99724-19-3
- Chemical Name:
- 3-N-Boc-aminopyrrolidine
- Synonyms
- TERT-BUTYL PYRROLIDIN-3-YLCARBAMATE;3-(BOC-AMINO)PYRROLIDINE;tert-butyl N-pyrrolidin-3-ylcarbamate;3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE;BOC-(+/-)-(3)APYROLIDI;Benzene,1-bromo-6-octyl-;3-N-BOC-AMINO PYRROLIDINE;BOC-(+/-)-3-AMINOPYRROLIDINE;3-N-Boc-aMinoMethypyrrolidine;9H-FLUORENE-2,12-DICARBOXYLICACID
- CBNumber:
- CB5767919
- Molecular Formula:
- C9H18N2O2
- Molecular Weight:
- 186.25
- MDL Number:
- MFCD00059040
- MOL File:
- 99724-19-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 67 °C |
|---|---|
| Boiling point | 286.4±29.0 °C(Predicted) |
| Density | 1.04±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in Methanol(almost transparency). |
| pka | 12.37±0.20(Predicted) |
| form | powder to crystal |
| color | White to Light yellow to Light orange |
| Sensitive | Air Sensitive |
| InChI | 1S/C9H18N2O2/c1-9(2,3)13-8(12)11-7-4-5-10-6-7/h7,10H,4-6H2,1-3H3,(H,11,12) |
| InChIKey | DQQJBEAXSOOCPG-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)NC1CCNC1 |
| CAS DataBase Reference | 99724-19-3(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
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3-N-Boc-aminopyrrolidine price More Price(76)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 721832 | 3-(Boc-amino)pyrrolidine 95% | 99724-19-3 | 1g | $103 | 2026-04-30 | Buy |
| TCI Chemical | B1358 | 3-(tert-Butoxycarbonylamino)pyrrolidine >98.0%(GC)(T) | 99724-19-3 | 5g | $39 | 2026-04-30 | Buy |
| TCI Chemical | B1358 | 3-(tert-Butoxycarbonylamino)pyrrolidine >98.0%(GC)(T) | 99724-19-3 | 25g | $127 | 2026-04-30 | Buy |
| Usbiological | 264150 | 3-(tert-Butoxycarbonylamino)-pyrrolidine Asreported | 99724-19-3 | 5g | $475 | 2026-06-03 | Buy |
| Usbiological | 264150 | 3-(tert-Butoxycarbonylamino)-pyrrolidine Asreported | 99724-19-3 | 10g | $681 | 2026-06-03 | Buy |
3-N-Boc-aminopyrrolidine Chemical Properties, Uses, Production
Uses
(+/-)-3-(Boc-amino)pyrrolidine is the homochiral starting materials utilised in the synthesis of all of the chiral compounds. Reactant in the peptide activated G-protein coupled receptors test.
Synthesis
99735-30-5
99724-19-3
General procedure for the synthesis of 3-(Boc-amino)pyrrolidine from 1-benzyl-3-(Boc-amino)pyrrolidine: 1-benzyl-3-(Boc-amino)pyrrolidine (15.75 g, 57.0 mmol) was dissolved in a solvent mixture of methanol and tetrahydrofuran (4:1, 114 ml) in a 500 ml reaction vessel. A catalytic amount of 10% palladium/carbon (Pd/C) was added to the solution. The reaction mixture was stirred and reacted for 12 hours under hydrogen atmosphere. Upon completion of the reaction, the palladium/carbon catalyst was removed by filtration through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure to remove the solvent. The resulting residue was purified by silica gel column chromatography to afford 3-(Boc-amino)pyrrolidine (9.51 g, 99% yield). The product was characterized by 1H-NMR (200 MHz, CDCl3): δ 1.41 (s, 9H), 2.26 (m, 2H), 2.55 (m, 3H), 2.74 (m, 1H), 4.84 (br, 1H).LC-MS analysis showed [M+H]+ peak of 187.
References
[1] Patent: WO2008/54154, 2008, A1. Location in patent: Page/Page column 76; 81; 162-163; 168
[2] Patent: WO2007/52938, 2007, A1. Location in patent: Page/Page column 23
[3] Patent: US5281612, 1994, A
[4] Patent: US4604401, 1986, A
[5] Patent: US4617308, 1986, A
3-N-Boc-aminopyrrolidine Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Sichuan Guanghan Bio-Tech Co., Ltd | +86-28-86127071 | info@sino-produce.com | China | 400 | 66 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
View Latest Price from 3-N-Boc-aminopyrrolidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 3-N-Boc-aminopyrrolidine
99724-19-3
|
$8.00 | 1KG | 99% | 10tons | Career Henan Chemical Co |
-
- 3-N-Boc-aminopyrrolidine
99724-19-3
- $8.00
- 99%
- Career Henan Chemical Co
