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1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid structure

CAS No.: 113100-53-1

Chemical Name:: 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Synonyms: 1-Methyl-3-(trifluoromethyl)-1H-pyrazol-4-carboxylic acid;-3-(trifL;)-1H-pyrazoL;BUTTPARK 99\18-24;1H-Pyrazole-4-carboxylic acid, 1-methyl-3-;4-Carboxy-1-methyl-3-(trifluoromethyl)-1H-pyrazole;1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxy;1-METHYL-3-TRIFLUOROMETHYLPYRAZOLE-4-CARBOXYLIC ACID;1-Methyl-3-trifluoromethyl-4-pyrazolecarboxylic Acid;2-Methyl-5-trifluoromethyl-2H-pyrazole-3-carbonylchloride

CBNumber:: CB5768709

Molecular Formula:: C6H5F3N2O2

Molecular Weight:: 194.11

MDL Number:: MFCD01936005

MOL File:: 113100-53-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:53:41

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1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid Properties

Melting point	203 °C
Boiling point	285.6±40.0 °C(Predicted)
Density	1.56±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	2.93±0.36(Predicted)
color	White to Off-White
InChI	InChI=1S/C6H5F3N2O2/c1-11-2-3(5(12)13)4(10-11)6(7,8)9/h2H,1H3,(H,12,13)
InChIKey	FZNKJQNEJGXCJH-UHFFFAOYSA-N
SMILES	N1(C)C=C(C(O)=O)C(C(F)(F)F)=N1
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36/37/39-24/25

WGK Germany

HazardClass

IRRITANT

HS Code

29331990

Storage Class

11 - Combustible Solids

NFPA 704

	0
2		0

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid price More Price(64)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	705527	3-(Trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid 97%	113100-53-1	1g	$63.4	2023-06-20	Buy
TCI Chemical	M2628	1-Methyl-3-(trifluoromethyl)pyrazole-4-carboxylic Acid >98.0%(GC)(T)	113100-53-1	1g	$35	2026-04-30	Buy
Usbiological	291533	3-(Trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid Asreported	113100-53-1	500mg	$333	2026-06-03	Buy
Usbiological	291533	3-(Trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid Asreported	113100-53-1	1g	$463	2026-06-03	Buy
Usbiological	291533	3-(Trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid Asreported	113100-53-1	2g	$622	2026-06-03	Buy

Product number	Packaging	Price	Buy
705527	1g	$63.4	Buy
M2628	1g	$35	Buy
291533	500mg	$333	Buy
291533	1g	$463	Buy
291533	2g	$622	Buy

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid Chemical Properties, Uses, Production

Chemical Properties

White solid

Uses

3-(Trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic Acid is used in the synthesis of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase. Also used in the synthesis of 4-carboxamide derivatives acting as antifungal agents.

Synthesis

ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE

111493-74-4

113100-53-1

General procedure for the synthesis of 1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid from ethyl 1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylate: to a reaction vial, ethyl 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate (5600 mg, 25 mmol) and potassium hydroxide (4740 mg, 30 mmol) were added in 50 mL of solvent. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the reaction solution was acidified to pH 1 with dilute hydrochloric acid and a white solid product was precipitated. The solid was collected by filtration and washed with an appropriate solvent and dried to give 1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid in 59% yield with a melting point of 195-196 °C. The structure of the product was confirmed by 1H NMR (500 MHz, DMSO-d6) with chemical shifts of δ 12.80 (s, 1H, COOH), 8.44 (s, 1H, CH on the pyrazole ring), 3.93 (s, 3H, CH3).

References

[1] Angewandte Chemie - International Edition, 2017, vol. 56, # 16, p. 4569 - 4574
[2] Angew. Chem., 2017, vol. 129, # 16, p. 4640 - 4645,6
[3] Molecules, 2012, vol. 17, # 12, p. 14205 - 14218
[4] Journal of Molecular Structure, 2018, vol. 1171, p. 631 - 638
[5] Patent: EP2263999, 2010, A1. Location in patent: Page/Page column 21-22

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid synthesis

Synthesis of 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid from 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbonitrile

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid Preparation Products And Raw materials

Raw materials

Ethyl vinyl ether Ethyl 4,4,4-trifluoroacetoacetate Hexane tert-Butyllithium Acetic anhydride

Triethyl orthoformate Sodium thiosulfate Trifluoroacetic acid Carbon dioxide Pentane

Tetrahydrofuran Diethyl ether Bromine Methylhydrazine Methanol

Sodium hydroxide Iron 4-Dimethylaminopyridine

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Preparation Products

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid Suppliers

Global Suppliers ( 251)

Supplier	Tel	Email	Country	ProdList	Advantage
Fluoropharm Co., Ltd.	0571-85586753 13336034509	sales@fluoropharm.com	China	1288	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Ark Pharm, Inc.	847-367-3680	sales@arkpharminc.com	United States	1669	56
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60

Supplier	Advantage
Fluoropharm Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Ark Pharm, Inc.	56
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
Beijing Ouhe Technology Co., Ltd	60
JinYan Chemicals(ShangHai) Co.,Ltd.	60

View Latest Price from 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-25	1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 113100-53-1	$2.00-5.00	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2025-12-29	1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 113100-53-1		1kg	98%		Changzhou waston chemical technology Co.,Ltd
2019-07-06	1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 113100-53-1	$1.00	1kg	98%	100KG	Career Henan Chemical Co

1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
113100-53-1
$2.00-5.00
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
113100-53-1
$0.00
98%
Changzhou waston chemical technology Co.,Ltd

1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
113100-53-1
$1.00
98%
Career Henan Chemical Co

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid Spectrum

1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID(113100-53-1)¹HNMR

113100-53-1 (1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid) Related Search:

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1-METHYL-3-TRIFLUOROMETHYLPYRAZOLE-4-CARBOXYLIC ACID 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid ,97% BUTTPARK 99\18-24 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxy 1-Methyl-3-trifluoromethyl-4-pyrazolecarboxylic Acid 2-Methyl-5-trifluoromethyl-2H-pyrazole-3-carbonylchloride 3-(TrifluoroMethyl)-1-Methyl-1H-pyrazole-4-carboxylic acid 4-Carboxy-1-methyl-3-(trifluoromethyl)-1H-pyrazole 3-(Trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid 97% 1-Methyl-3-(trifluoromethyl)pyrazole-4-carboxylic Acid > 1H-Pyrazole-4-carboxylic acid, 1-methyl-3-(trifluoromethyl)- )-1H-pyrazoL -3-(trifL 1H-Pyrazole-4-carboxylic acid, 1-methyl-3- 3-(Trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid 1-Methyl-3-(trifluoromethyl)-1H-pyrazol-4-carboxylic acid 193-(triFluoroMethyl)-1-Methyl-1H-pyrazole-4-carboxylic acid 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid 113100-53-1 C6H5F3N2O2 Building Blocks Pyrazole