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2,4-DICHLORO-3-NITRO-QUINOLINE

2,4-DICHLORO-3-NITRO-QUINOLINE structure

CAS No.: 132521-66-5

Chemical Name:: 2,4-DICHLORO-3-NITRO-QUINOLINE

Synonyms: Zinc02551827;AURORA KA-4144;2,4-Dichlor-3-nitro-chinolin;3-NITRO-2,4-DICHLORO QUINOLINE;2,4-DICHLORO-3-NITRO-QUINOLINE;Quinoline, 2,4-dichloro-3-nitro-;2,4-Dichloro-3-nitroquinoline 95%;Benzaldehyde,4-methoxy-4-(phenylmethoxy)-;2,4-DICHLORO-3-NITRO-QUINOLINE ISO 9001：2015 REACH

CBNumber:: CB5773772

Molecular Formula:: C9H4Cl2N2O2

Molecular Weight:: 243.05

MDL Number:: MFCD05666285

MOL File:: 132521-66-5.mol

MSDS File:: SDS

Last updated:2026-07-09 12:03:46

Product description	Number	Pack Size	Price
2,4-Dichloro-3-nitroquinoline	TRC-D439308-50MG	50mg	$168
2,4-Dichloro-3-nitroquinoline	TRC-D439308-10MG	10mg	$70
2,4-Dichloro-3-nitroquinoline	TRC-D439308-100MG	100mg	$261
2,4-Dichloro-3-nitroquinoline	FD159596	5g	$324.5
2,4-Dichloro-3-nitroquinoline	FD159596	10g	$519.2
More product size

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2,4-DICHLORO-3-NITRO-QUINOLINE Properties

Melting point	102 °C(Solv: methanol (67-56-1); ethyl acetate (141-78-6))
Boiling point	359.7±37.0 °C(Predicted)
Density	1.593±0.06 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	-4.98±0.50(Predicted)
color	White to Off-White
InChI	InChI=1S/C9H4Cl2N2O2/c10-7-5-3-1-2-4-6(5)12-9(11)8(7)13(14)15/h1-4H
InChIKey	RSFJVCHKGRUCIC-UHFFFAOYSA-N
SMILES	N1C2C(=CC=CC=2)C(Cl)=C([N+]([O-])=O)C=1Cl

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
HS Code	2933499090

2,4-DICHLORO-3-NITRO-QUINOLINE price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-D439308-50MG	2,4-Dichloro-3-nitroquinoline	132521-66-5	50mg	$168	2026-06-03	Buy
TRC	TRC-D439308-10MG	2,4-Dichloro-3-nitroquinoline	132521-66-5	10mg	$70	2026-06-03	Buy
TRC	TRC-D439308-100MG	2,4-Dichloro-3-nitroquinoline	132521-66-5	100mg	$261	2026-06-03	Buy
Biosynth	FD159596	2,4-Dichloro-3-nitroquinoline	132521-66-5	5g	$324.5	2026-06-04	Buy
Biosynth	FD159596	2,4-Dichloro-3-nitroquinoline	132521-66-5	10g	$519.2	2026-06-04	Buy

Product number	Packaging	Price	Buy
TRC-D439308-50MG	50mg	$168	Buy
TRC-D439308-10MG	10mg	$70	Buy
TRC-D439308-100MG	100mg	$261	Buy
FD159596	5g	$324.5	Buy
FD159596	10g	$519.2	Buy

2,4-DICHLORO-3-NITRO-QUINOLINE Chemical Properties,Uses,Production

Uses

2,4-Dichloro-3-nitroquinoline has antitumor activity.

Description

2,4-Dichloro-3-nitroquinoline is a chemotherapeutic drug that belongs to the class of epidermal growth factor receptor (EGFR) inhibitors. This agent has anticancer activity against cells in the G1 phase of the cell cycle and may also have some antiproliferative effects on tumor cells. 2,4-Dichloro-3-nitroquinoline binds to EGFR and inhibits the binding of epidermal growth factor (EGF) to its receptor. This binding causes the activation of downstream signaling pathways that regulate cell proliferation.

Uses

2,4-Dichloro-3-nitroquinoline has antitumor activity.

Synthesis

15151-57-2

132521-66-5

(2) Synthesis of 2,4-dichloro-3-nitroquinoline: In a 20 mL round-bottomed flask, 3-nitroquinoline-2,4-diol (1 g, 4.85 mmol), phosphorus trichloride (appropriate amount) and N,N-dimethylaniline (0.19 mL) were added sequentially. The reaction mixture was stirred at 90 °C for 2 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature, slowly poured into ice water, and stirring was continued for 0.5 hours. The precipitate precipitated was collected by filtration and dried under vacuum overnight. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=5:1, v/v) to give 0.7 g of white solid product in 59.4% yield.

References

[1] Medicinal Chemistry Research, 2014, vol. 23, # 6, p. 2964 - 2975
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 11, p. 4450 - 4465
[3] Patent: WO2013/67597, 2013, A1. Location in patent: Page/Page column 78
[4] Patent: WO2018/191746, 2018, A1. Location in patent: Paragraph 0391
[5] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 8, p. 921 - 926

2,4-DICHLORO-3-NITRO-QUINOLINE Preparation Products And Raw materials

Raw materials

2,4-DIHYDROXY-3-NITROQUINOLINE

Preparation Products

2-Chloro-N4-(2-methypropyl)-3,4-quinolinediamine

2,4-DICHLORO-3-NITRO-QUINOLINE Suppliers

Global( 103)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19935	58
Dideu Industries Group Limited	+8617392712697	1022@dideu.com	China	29094	58
Zhengzhou Anbu Chem Co.,Ltd	+86-0371-88006763; +86-15988602810	sales@anbuchem.com	China	5812	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850 +86-15355479329	market18@leapchem.com	China	43303	58
Aladdin Scientific		tp@aladdinsci.com	United States	50108	58
Shaanxi Dideu New Materials Co. Ltd	18192503167	1036@dideu.com	China	13278	58
Shenzhen Nexcon Pharmatechs Ltd.	+86-0755-89396905 +86-18025329037	admin@nexconn.com	China	6197	58
NANJING YINGWEN BIOTECHNOLOGY CO LTD	+86-13382787392	sales@aeechem.com	China	10002	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58

Supplier	Advantage
career henan chemical co	58
BOC Sciences	58
Dideu Industries Group Limited	58
Zhengzhou Anbu Chem Co.,Ltd	58
HANGZHOU LEAP CHEM CO., LTD.	58
Aladdin Scientific	58
Shaanxi Dideu New Materials Co. Ltd	58
Shenzhen Nexcon Pharmatechs Ltd.	58
NANJING YINGWEN BIOTECHNOLOGY CO LTD	58
Amadis Chemical Company Limited	58

View Lastest Price from 2,4-DICHLORO-3-NITRO-QUINOLINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-20	2,4-DICHLORO-3-NITRO-QUINOLINE 132521-66-5	$1.10	1g	99.00%	5760-20-3	Dideu Industries Group Limited
2026-07-08	2,4-dichloro-3-nitroquinoline 132521-66-5		1kg	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd
2026-06-30	2,4-DICHLORO-3-NITRO-QUINOLINE 132521-66-5		1kg	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd

2,4-DICHLORO-3-NITRO-QUINOLINE
132521-66-5
$1.10
99.00%
Dideu Industries Group Limited

2,4-dichloro-3-nitroquinoline
132521-66-5
98%
Shaanxi Dideu New Materials Co. Ltd

2,4-DICHLORO-3-NITRO-QUINOLINE
132521-66-5
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

2,4-DICHLORO-3-NITRO-QUINOLINE Spectrum

2,4-DICHLORO-3-NITRO-QUINOLINE(132521-66-5)¹HNMR 2,4-DICHLORO-3-NITRO-QUINOLINE(132521-66-5)FT-IR

132521-66-5(2,4-DICHLORO-3-NITRO-QUINOLINE)Related Search:

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AURORA KA-4144 2,4-DICHLORO-3-NITRO-QUINOLINE 3-NITRO-2,4-DICHLORO QUINOLINE 2,4-Dichlor-3-nitro-chinolin Zinc02551827 2,4-Dichloro-3-nitroquinoline 95% Quinoline, 2,4-dichloro-3-nitro- 2,4-DICHLORO-3-NITRO-QUINOLINE ISO 9001：2015 REACH Benzaldehyde,4-methoxy-4-(phenylmethoxy)- 132521-66-5