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4-Chloro-3-nitropyridine

4-Chloro-3-nitropyridine Structure
4-Chloro-3-nitropyridine structure
CAS No.
13091-23-1
Chemical Name:
4-Chloro-3-nitropyridine
Synonyms
3-nitro-4-chloropyridine;4-Chlor-3-nitro-pyridin;4-CHLORO-3-NITROPYRIDINE;Pyridine, 4-chloro-3-nitro-;4-CHLORO-3-NITROPYRIDINE 98%;4-chloro-3-nitropyridine, 97%,;4-Chloro-3-nitropyridine, tech.;4-Chloro-3-nitropyridine;4-Chloro-3-nitropyridine ISO 9001：2015 REACH;4-CHLORO-3-NITROPYRIDINE 4-CHLORO-3-NITROPYRIDINE
CBNumber:
CB0471099
Molecular Formula:
C5H3ClN2O2
Molecular Weight:
158.54
MDL Number:
MFCD02683025
MOL File:
13091-23-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 22:42:19
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4-Chloro-3-nitropyridine Properties

Melting point 35-50 °C
Boiling point 95 °C(Press: 5 Torr)
Density 1.489±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility Chloroform (Slightly), Methanol (Slightly)
pka 0.56±0.10(Predicted)
form Crystalline Powder
color Pale yellow
Water Solubility Insoluble in water.
InChI InChI=1S/C5H3ClN2O2/c6-4-1-2-7-3-5(4)8(9)10/h1-3H
InChIKey JOTRPRKONYTVBV-UHFFFAOYSA-N
SMILES C1=NC=CC(Cl)=C1[N+]([O-])=O
CAS DataBase Reference 13091-23-1(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Skull and Crossbones (GHS06)
GHS05,GHS06
Signal word  Danger
Hazard statements  H301-H318
Precautionary statements  P280-P301+P310+P330-P305+P351+P338+P310
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xi,Xn
Risk Statements  20/21/22-36/37/38-41-22
Safety Statements  26-36/37/39-36/39-37/38-36
RIDADR  UN 2811
WGK Germany  3
Hazard Note  Irritant
HazardClass  IRRITANT, KEEP COLD
PackingGroup  III
HS Code  29333990
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
Eye Dam. 1
NFPA 704
1
3 0

4-Chloro-3-nitropyridine price More Price(64)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 674079 4-Chloro-3-nitropyridine 90% 13091-23-1 5g $73.1 2026-04-30 Buy
Usbiological C5029-17 4-Chloro-3-nitropyridine (4-Chlor-3-nitro-pyridin) 13091-23-1 1g $403 2026-06-03 Buy
Usbiological 233048 4-Chloro-3-nitropyridine 99+% (GC) ≥99%(GC) 13091-23-1 1g $156 2026-06-03 Buy
Usbiological 233048 4-Chloro-3-nitropyridine 99+% (GC) ≥99%(GC) 13091-23-1 5g $177 2026-06-03 Buy
Usbiological 233048 4-Chloro-3-nitropyridine 99+% (GC) ≥99%(GC) 13091-23-1 25g $297 2026-06-03 Buy
Product number Packaging Price Buy
674079 5g $73.1 Buy
C5029-17 1g $403 Buy
233048 1g $156 Buy
233048 5g $177 Buy
233048 25g $297 Buy

4-Chloro-3-nitropyridine Chemical Properties, Uses, Production

Chemical Properties

Snuff color to brown powder

Uses

4-Chloro-3-nitropyridine (cas# 13091-23-1) is a compound useful in organic synthesis.

Synthesis

4-Hydroxy-3-nitropyridine

5435-54-1

4-Chloro-3-nitropyridine

13091-23-1

Example 1: General procedure for the synthesis of 4-chloro-3-nitropyridine from 4-hydroxy-3-nitropyridine Step 1: Synthesis of 4-chloro-3-nitropyridine To a suspension of 3-nitro-4-pyridinol (20 g, 143 mmol) in toluene (300 mL) was slowly added phosphorus trichloride (65.7 g, 429 mmol) at 0 °C. The reaction mixture was gradually warmed to room temperature and subsequently heated to reflux (110 °C) and held for 16 hours. After completion of the reaction, the mixture was cooled to room temperature and the solvent was removed by rotary evaporator under reduced pressure. The residue was carefully poured into ice water and the pH was adjusted with potassium carbonate (K2CO3) to 10. The aqueous phase was extracted with ethyl acetate and the organic phase was washed sequentially twice with water and once with brine. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a brown oil, which solidified on standing to the target product 4-chloro-3-nitropyridine (22.5 g, 99% yield). Mass spectrum (electrospray positive ion mode) m/e 159 [M+H]+.

References

[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 1, p. 2 - 5
[2] Patent: WO2005/37197, 2005, A2. Location in patent: Page/Page column 80; 83
[3] Patent: WO2005/37198, 2005, A2. Location in patent: Page/Page column 20
[4] Patent: WO2005/51304, 2005, A2. Location in patent: Page/Page column 70

4-Chloro-3-nitropyridine Preparation Products And Raw materials

Raw materials

Nitrogen 4-Hydroxy-3-nitropyridine Phosphorus oxitrichloride Chloroform Phosphorus pentachloride
Magnesium sulfate Ammonia 4-hydroxypyridinium nitrate 4-Pyridinamine, N,3-dinitro- 4-Hydroxy-3-nitropyridine
4-Hydroxypyridine 1,1-Dichloroethane 4-Hydroxypyridine

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Preparation Products

3-Amino-4-chloropyridine 5-Nitro-2-hydroxy-4-methoxypyridine 4-Benzyloxy-3-indoleacetonitrile 10H-Dipyrido[4,3-b:4',3'-e][1,4]thiazine 4-(Dimethylamino)-3-nitropyridine
4-Amino-3-nitropyridine 4-Ethenyl-3-nitropyridine

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4-Chloro-3-nitropyridine Suppliers

Global Suppliers ( 413)
Supplier Tel Email Country ProdList Advantage
Nanjing Norris-Pharm Technology Co., Ltd 13901585132 sales@norris-pharm.com China 8869 55
Shandong Meiao Huawei Technology Co., LTD 0531-88682301 18595278766 yuhongmeng@mayowell.com China 88 58
Nanjing Pope Bio-tech R&D Co., Ltd 025-87138562 18951783565 sales@popebiotech.com China 1203 58
Ningbo jinuo chemical co., LTD 0574-87314919 057487319282 info@nbinno.com China 7046 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 45000 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Supplier Advantage
Nanjing Norris-Pharm Technology Co., Ltd 55
Shandong Meiao Huawei Technology Co., LTD 58
Nanjing Pope Bio-tech R&D Co., Ltd 58
Ningbo jinuo chemical co., LTD 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
Alfa Aesar 84
Energy Chemical 61
Capot Chemical Co., Ltd 66

View Latest Price from 4-Chloro-3-nitropyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Chloro-3-nitropyridine pictures 2026-10-13 4-Chloro-3-nitropyridine
13091-23-1
 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
4-Chloro-3-nitropyridine pictures 2026-09-02 4-Chloro-3-nitropyridine
13091-23-1
 $1.00-200.00 1KG 99% Henan Fengda Chemical Co., Ltd
4-Chloro-3-nitropyridine pictures 2026-08-20 4-Chloro-3-nitropyridine
13091-23-1
 $1.10 1g 99.00% 100 Tons min Dideu Industries Group Limited

4-Chloro-3-nitropyridine Spectrum

4-Chloro-3-nitropyridine(13091-23-1)1HNMR

13091-23-1 (4-Chloro-3-nitropyridine) Related Search:

2,3,5,6-Tetrachloropyridine 4-Nitrophenyl chloroformate 2-Chloro-5-chloromethylpyridine 3-Nitropyridine 1-Chloro-3-nitrobenzene
Clopidol 2-Chloropyridine-N-oxide 4-Chloro-3-nitrophenol 4-Chloro-3-nitropyridine hydrochloride, 97+%,4-Chloro-3-nitropyridine hydrochloride, 98+%,4-CHLORO-3-NITROPYRIDINE HYDROCHLORIDE, 90+% 2-AMINO-4-CHLORO-3-NITROPYRIDINE
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4-Chloro-3-nitropyridine, 95%, may cont. variable amounts of oligomers 4-Chloro-3-Nitropyridine, May Cont. Variable Amounts of Oligomers 4-Chloro-3-nitropyridine, tech. 4-CHLORO-3-NITROPYRIDINE 98% 4-CHLORO-3-NITROPYRIDINE 4-CHLORO-3-NITROPYRIDINE 4-Chloro-3-nitropyridine 4-Chlor-3-nitro-pyridin 4-CHLORO-3-NITROPYRIDINE Pyridine, 4-chloro-3-nitro- 4-Chloro-3-nitropyridine ISO 9001：2015 REACH 4-chloro-3-nitropyridine, 97%, 3-nitro-4-chloropyridine 13091-23-1 1309-23-1 Pyridines Halogenated Heterocycles Heterocyclic Building Blocks Building Blocks Bases & Related Reagents Heterocycles Nucleotides C5Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks alkyl chloride | nitro-compound Pyridine series Pyridine Pyridines Nucleotides and Nucleosides Pyridines, Pyrimidines, Purines and Pteredines bc0001