Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>(Tetrahydro-2H-pyran-4-yl)methanol

(Tetrahydro-2H-pyran-4-yl)methanol

(Tetrahydro-2H-pyran-4-yl)methanol Structure
(Tetrahydro-2H-pyran-4-yl)methanol structure
CAS No.
14774-37-9
Chemical Name:
(Tetrahydro-2H-pyran-4-yl)methanol
Synonyms
TETRAHYDROPYRAN-4-METHANOL;oxan-4-ylMethanol;15N]-Ammonium Chloride;Tetrahydropyran-4-Methano;TERTAHYDROPYRAN-4-METHANOL;4-(Hydroxymethyl)tetrahyd...;4-(Hydroxymethyl)tetrahydropyr;Tetrahydropyran-4-methanol?New;4-(Hydroxymethyl)tetrahydropyran;(TETRAHYDRO-PYRAN-4-YL)-METHANOL
CBNumber:
CB5780709
Molecular Formula:
C6H12O2
Molecular Weight:
116.16
MDL Number:
MFCD00457804
MOL File:
14774-37-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:53:41
Request For Quotation

(Tetrahydro-2H-pyran-4-yl)methanol Properties

Boiling point 105 °C
Density 1.000±0.06 g/cm3(Predicted)
Flash point 61°(142°F)
refractive index 1.4600
storage temp. Sealed in dry,Room Temperature
pka 14.85±0.10(Predicted)
form clear liquid
color Colorless to Light yellow to Light orange
Water Solubility Slightly soluble in water.
InChI InChI=1S/C6H12O2/c7-5-6-1-3-8-4-2-6/h6-7H,1-5H2
InChIKey YSNVSVCWTBLLRW-UHFFFAOYSA-N
SMILES C1OCCC(CO)C1
CAS DataBase Reference 14774-37-9(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Warning
Hazard statements  H227-H315-H318-H335
Precautionary statements  P210e-P261-P280a-P305+P351+P338-P405-P501a
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-22-41-37/38
Safety Statements  26-36/37/39-23-39
HazardClass  IRRITANT
HS Code  29329990
NFPA 704
1
2 0

(Tetrahydro-2H-pyran-4-yl)methanol price More Price(71)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical T2965 Tetrahydropyran-4-methanol >97.0%(GC) 14774-37-9 1g $59 2026-04-30 Buy
TCI Chemical T2965 Tetrahydropyran-4-methanol min. 97.0 % 14774-37-9 5G $378 2026-04-30 Buy
AstaTech 66550 4-HYDROXYMETHYLTETRAHYDROPYRAN 97% 14774-37-9 5G $26 2026-04-30 Buy
AstaTech 66550 4-HYDROXYMETHYLTETRAHYDROPYRAN 97% 14774-37-9 25G $78 2026-04-30 Buy
AstaTech 66550 4-HYDROXYMETHYLTETRAHYDROPYRAN 97% 14774-37-9 100G $210 2026-04-30 Buy
Product number Packaging Price Buy
T2965 1g $59 Buy
T2965 5G $378 Buy
66550 5G $26 Buy
66550 25G $78 Buy
66550 100G $210 Buy

(Tetrahydro-2H-pyran-4-yl)methanol Chemical Properties, Uses, Production

Chemical Properties

Colorless liquid

Uses

Used as a reagent in the identification and optimization of pteridinone Toll-like receptor 7 agonists, which can be used for the oral treatment of viral hepatitis. 4-(Hydroxymethyl)tetrahydropyran is also a starting material for [1-[(Tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)methanone which is a drug that acts as CB2 cannabinoid receptor agonist.

Synthesis

Ethyl Tetrahydropyran-4-Carboxylate

96835-17-5

(TETRAHYDRO-2H-PYRAN-4-YL)METHANOL

14774-37-9

Ethyl tetrahydro-2H-pyran-4-carboxylate (5.0 g, 34.7 mmol) was slowly added to a stirred suspension of lithium aluminum hydride (LiAlH4, 4.0 g, 104 mmol) in tetrahydrofuran (THF, 100 mL) at 0 °C. The reaction mixture was kept stirred at 0 °C for 1 hour. Subsequently, ethyl acetate (20 mL) was added slowly and dropwise to the reaction mixture to quench the excess LiAlH4, followed by the addition of 10% aqueous sodium hydroxide (NaOH). The resulting mixture was continued to be stirred for 30 minutes. Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad to remove insoluble impurities. The filtrate was concentrated under reduced pressure to give the target product (tetrahydro-2H-pyran-4-yl) methanol (9) as a colorless oil. The yield was 3.9 g in 96% yield. The product was characterized by 1H NMR (400 MHz, DMSO-d5): δ 4.46 (broad single peak, 1H), 3.82 (double peak, J=8.0 Hz, 2H), 3.25-3.22 (multiple peaks, 4H), 1.62-1.52 (multiple peaks, 3H), 1.18-1.04 (multiple peaks, 1H).

References

[1] Patent: US2014/275043, 2014, A1. Location in patent: Paragraph 0415; 0416
[2] Justus Liebigs Annalen der Chemie, 1936, vol. 525, p. 292,294
[3] Patent: WO2010/96371, 2010, A2. Location in patent: Page/Page column 156

(Tetrahydro-2H-pyran-4-yl)methanol synthesis

96835-17-5
14774-37-9
Synthesis of (Tetrahydro-2H-pyran-4-yl)methanol from Ethyl Tetrahydropyran-4-Carboxylate

(Tetrahydro-2H-pyran-4-yl)methanol Preparation Products And Raw materials

Raw materials

Ethanol Potassium hydroxide Acetone Sodium Tetrahydro-2H-pyran-4-carboxylic acid
2,2'-Dichlorodiethyl ether Tetrahydrofuran Lithium Aluminum Hydride Diethyl malonate Methyl tetrahydropyran-4-carboxylate

1of2

Preparation Products

Tetrahydropyran-4-carbaldehyde 1-azabicyclo[2.2.1]heptane 4-(Iodomethyl)tetrahydro-2H-pyran Tetrahydropyranyl-4-acetic acid 4-(Bromomethyl)tetrahydropyran
Tetrahydro-2H-pyran-2-ylmethyl 4-methylbenzenesulfonate

1of2

(Tetrahydro-2H-pyran-4-yl)methanol Suppliers

Global Suppliers ( 278)
Supplier Tel Email Country ProdList Advantage
ITIC MEDCHEM(SUZHOU) CO.,LTD. 0512-68323967 18015559028 sales@iticmedchem.com China 528 61
ChongQing Purel Bio-Pharmaceutical Technology Co., Ltd. 023-89130144 18523560356 zhyong1011@163.com China 297 58
Yanggu Rongke Trading Co. , Ltd. 0635-6725226 15863541132 yglida@163.com China 61 65
Yanggu Rongke Trading Co., Ltd 15863541132 18366413387@163.com China 5723 58
BTC Pharmaceutical CO. Ltd +86-15716293042 15716293042 info@btcpharm.com China 822 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Supplier Advantage
ITIC MEDCHEM(SUZHOU) CO.,LTD. 61
ChongQing Purel Bio-Pharmaceutical Technology Co., Ltd. 58
Yanggu Rongke Trading Co. , Ltd. 65
Yanggu Rongke Trading Co., Ltd 58
BTC Pharmaceutical CO. Ltd 55
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61

View Latest Price from (Tetrahydro-2H-pyran-4-yl)methanol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(TETRAHYDRO-2H-PYRAN-4-YL)METHANOL pictures 2026-09-02 (TETRAHYDRO-2H-PYRAN-4-YL)METHANOL
14774-37-9
 $1.50-31.00 1kg 99% Henan Fengda Chemical Co., Ltd
(TETRAHYDRO-2H-PYRAN-4-YL)METHANOL pictures 2026-08-20 (TETRAHYDRO-2H-PYRAN-4-YL)METHANOL
14774-37-9
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
Tetrahydropyran-4-methanol pictures 2025-04-04 Tetrahydropyran-4-methanol
14774-37-9
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

(Tetrahydro-2H-pyran-4-yl)methanol Spectrum

(TETRAHYDRO-2H-PYRAN-4-YL)METHANOL(14774-37-9)1HNMR

14774-37-9 ((Tetrahydro-2H-pyran-4-yl)methanol) Related Search:

Tetrahydro-4H-pyran-4-one Tetrahydropyranyl-4-acetic acid MUCONOMYCIN A Ryanodine Tetrahydro-2H-pyran-4-carboxylic acid
Azadirachtin HT-2 TOXIN Tetrahydropyran TETRODOTOXIN CITRATE Azadirachtin h(SH)
FUSARENON X scirpentriol NEOSOLANIOL 4-phenyltetrahydropyran-4-carboxylic acid RORIDIN A
NIVALENOL T-2 TRIOL VERRUCAROL

1of4

(TETRAHYDRO-PYRAN-4-YL)-METHANOL TETRAHYDROPYRAN-4-METHANOL TERTAHYDROPYRAN-4-METHANOL 4-(Hydroxymethyl)tetrahydro-2H-pyran 4-(Hydroxymethyl)tetrahydropyr (Tetrahydro-pyran-4-yl)-methanol ,97% oxan-4-ylMethanol 4-(Hydroxymethyl)tetrahydropyran 4-(Hydroxymethyl)tetrahyd... tetrahydro-2H-pyran-4-ylmethanol(SALTDATA: FREE) (TETRAHYDRO-2H-PYRAN-4-YL)METHANO (Tetrahydro-2H-pyran-4-yl)methanol, (Oxan-4-yl)methanol Tetrahydropyran-4-Methano (Terahydro-2H-pyran-4-yl)methanol 4-(Hydroxymethyl)tetrahydro-2H-pyran98% 15N]-Ammonium Chloride 2H-Pyran-4-methanol, tetrahydro- (tetrahydrogen-2h-pyran-4-yl) methanol " Tetrahydro-4-hydroxymethyl-2H-pyran (TETRAHYDRO-2H-PYRAN-4-YL)METHANOL ISO 9001：2015 REACH Tetrahydropyran-4-methanol?New Chemicalbook4-(Hydroxymethyl)tetrahydro-2H-pyran 4-(Hydroxymethyl)tetrahydropyran, 98% Tetrahydropyran-4-methanol (Tetrahydro-2H-pyran-4-yl)methanol (Tetrahydro-2H-pyran-4-yl)methanol 14774-37-9 Pyrans, Piperidines &Piperazines Pyrans, Piperidines & Piperazines Heterocycles series Hydroxymethyl's Alcohols and Derivatives blocks Heterocycles