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8-Fluoro-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride

8-Fluoro-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride structure

CAS No.: 898832-40-1

Chemical Name:: 8-Fluoro-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride

Synonyms: 8-Fluoro-3,4-dihydro-2H-benzo[1,4]oxazine;2H-1,4-Benzoxazine, 8-fluoro-3,4-dihydro-;8-Fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazine;8-Fluoro-3,4-dihydro-2H-benzo[1,4]oxazine 1HCl salt;8-Fluoro-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride

CBNumber:: CB5805264

Molecular Formula:: C8H8FNO

Molecular Weight:: 153.15

MDL Number:: MFCD08544330

MOL File:: 898832-40-1.mol

MSDS File:: SDS

Last updated:2026-09-12 18:53:41

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8-Fluoro-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride Properties

Boiling point	238℃
Density	1.200
Flash point	98℃
storage temp.	Sealed in dry,Room Temperature
Appearance	Brown to reddish brown Liquid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P280-P305+P351+P338
HS Code	2934999090

8-Fluoro-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride price More Price(44)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	PC910934	8-Fluoro-3,4-dihydro-2H-1,4-benzoxazine 98%	898832-40-1	100mg	$37	2026-06-04	Buy
Apolloscientific	PC910934	8-Fluoro-3,4-dihydro-2H-1,4-benzoxazine 98%	898832-40-1	250mg	$45	2026-06-04	Buy
Apolloscientific	PC910934	8-Fluoro-3,4-dihydro-2H-1,4-benzoxazine 98%	898832-40-1	1g	$111	2026-06-04	Buy
Matrix Scientific	303571	8-Fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazine	898832-40-1	250.00mg	$43	2026-05-19	Buy
Matrix Scientific	303571	8-Fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazine	898832-40-1	1.00g	$102	2026-05-19	Buy

Product number	Packaging	Price	Buy
PC910934	100mg	$37	Buy
PC910934	250mg	$45	Buy
PC910934	1g	$111	Buy
303571	250.00mg	$43	Buy
303571	1.00g	$102	Buy

8-Fluoro-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride Chemical Properties, Uses, Production

Synthesis

8-FLUORO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE

560082-51-1

8-FLUORO-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE

898832-40-1

8-Fluoro-2H-1,4-benzoxazin-3(4H)-one (1.0 g, 5.9 mmol) was used as starting material, which was dissolved in THF (25 mL) and stirred to form a suspension at 0 °C to -5 °C. Subsequently, a THF solution of lithium aluminum hydride (7 mL, 1 M) was slowly added dropwise. After the dropwise addition, the reaction mixture was warmed to room temperature and stirring was continued for 2 hours. Upon completion of the reaction, the mixture was carefully poured into ice water to quench the reaction and extracted with ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to remove the solvent. The resulting residue was ground with ether to afford 8-fluoro-3,4-dihydro-2H-benzo[1,4]oxazine (0.8 g, 87% yield) as a dark brown solid. Mass spectrum (ESI+): m/z 154 [M+H]+. 1H NMR (DMSO-d6): δ 3.27 (2H, m), 4.11 (2H, m), 6.05 (1H, br s), 6.34 (2H, m), 6.58 (1H, m).

References

[1] Patent: WO2011/144578, 2011, A1. Location in patent: Page/Page column 30
[2] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 16, p. 4700 - 4704

8-Fluoro-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride synthesis

Synthesis of 8-Fluoro-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride from 8-Fluoro-2H-benzo[b][1,4]oxazin-3(4H)-one

8-Fluoro-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride Preparation Products And Raw materials

Raw materials

8-Fluoro-2H-benzo[b][1,4]oxazin-3(4H)-one Tetrahydrofuran Lithium Aluminum Hydride

Preparation Products

8-Fluoro-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride Suppliers

Global Suppliers ( 38)

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Norris-Pharm Technology Co., Ltd	13901585132	sales@norris-pharm.com	China	8869	55
Hangzhou Milestone Pharmtech Co., Ltd.	0571-82896630 18969958410	sales_hz@milestonepharmtech.com	China	4907	55
NovoChemy Ltd.	86-(0)21-31261262 373522135	sales@novochemy.com	China	6491	58
Shanghai Kahn Pharmaceutical Co., Ltd.	021-34979681; 17701870669	41513101@qq.com	China	1787	55
SuZhou ShiYa Biopharmaceuticals, Inc.	0512-0512-52358471 17715136450	sales@shiyabiopharm.com	China	9814	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
Jiaxing Deyi Chemical Co., Ltd.	86-0573-85866609 18367600069	945717149@qq.com	China	9506	58
Aikon International Limited	025-66061636 19370895928	qqyang@aikonchem.com	China	15810	58
Cool Pharm, Ltd	021-58581007 18019463053	sales@coolpharm.com	China	9999	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 17705817739	info@dycnchem.com	China	52451	58

Supplier	Advantage
Nanjing Norris-Pharm Technology Co., Ltd	55
Hangzhou Milestone Pharmtech Co., Ltd.	55
NovoChemy Ltd.	58
Shanghai Kahn Pharmaceutical Co., Ltd.	55
SuZhou ShiYa Biopharmaceuticals, Inc.	58
Amadis Chemical Company Limited	58
Jiaxing Deyi Chemical Co., Ltd.	58
Aikon International Limited	58
Cool Pharm, Ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58

8-Fluoro-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride Spectrum

8-FLUORO-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE(898832-40-1)¹HNMR

898832-40-1 (8-Fluoro-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride) Related Search:

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8-Fluoro-3,4-dihydro-2H-benzo[1,4]oxazine 1HCl salt 8-Fluoro-3,4-dihydro-2H-benzo[1,4]oxazine 2H-1,4-Benzoxazine, 8-fluoro-3,4-dihydro- 8-Fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazine 8-Fluoro-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride 898832-40-1