1-(5-CHLOROPYRIDIN-2-YL)ETHANONE
- CAS No.
- 94952-46-2
- Chemical Name:
- 1-(5-CHLOROPYRIDIN-2-YL)ETHANONE
- Synonyms
- 2-Acetyl-5-chloropyridine;1-(5-chloropyridin-2-yl)ethan-1-one;Ethanone, 1-(5-chloro-2-pyridinyl)-;KML-81;KML-113;1-(5-chloro-2-pyridinyl)ethanone;1-(5-CHLOROPYRIDIN-2-YL)ETHANONE;1-(5-CHLOROPYRIDIN-2-YL)ETHANONE ISO 9001：2015 REACH
- CBNumber:
- CB5812099
- Molecular Formula:
- C7H6ClNO
- Molecular Weight:
- 155.58
- MDL Number:
- MFCD07375071
- MOL File:
- 94952-46-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2-Acetyl-5-chloropyridine >98% | OR345463 | 1g | $21 |
| 2-Acetyl-5-chloropyridine >98% | OR345463 | 5g | $30 |
| 2-Acetyl-5-chloropyridine >98% | OR345463 | 25g | $128 |
| 2-Acetyl-5-chloropyridine >98% | OR345463 | 100g | $452 |
| 2-Acetyl-5-chloropyridine 98% | AS26393 | 1g | $33 |
| More product size | |||
| Boiling point | 236.8±20.0 °C(Predicted) |
|---|---|
| Density | 1.233±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 0.72±0.10(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C7H6ClNO/c1-5(10)7-3-2-6(8)4-9-7/h2-4H,1H3 |
| InChIKey | VVYMEQBXUFPILB-UHFFFAOYSA-N |
| SMILES | C(=O)(C1=NC=C(Cl)C=C1)C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H315-H335 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
| HS Code | 2933399990 |
1-(5-CHLOROPYRIDIN-2-YL)ETHANONE price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR345463 | 2-Acetyl-5-chloropyridine >98% | 94952-46-2 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR345463 | 2-Acetyl-5-chloropyridine >98% | 94952-46-2 | 5g | $30 | 2026-06-04 | Buy |
| Apolloscientific | OR345463 | 2-Acetyl-5-chloropyridine >98% | 94952-46-2 | 25g | $128 | 2026-06-04 | Buy |
| Apolloscientific | OR345463 | 2-Acetyl-5-chloropyridine >98% | 94952-46-2 | 100g | $452 | 2026-06-04 | Buy |
| Activate Scientific | AS26393 | 2-Acetyl-5-chloropyridine 98% | 94952-46-2 | 1g | $33 | 2026-06-04 | Buy |
1-(5-CHLOROPYRIDIN-2-YL)ETHANONE Chemical Properties,Uses,Production
Uses
1-(5-chloropyridin-2-yl)ethanone is used as an intermediate of Nirogacestat, mainly used in the treatment of fibroma.
Synthesis
89809-64-3
75-16-1
94952-46-2
a) Under nitrogen protection, 5-chloro-2-cyanopyridine (10.7 g, 77 mmol) was dissolved in a solvent mixture of ether (65 mL) and tetrahydrofuran (THF, 35 mL). The reaction mixture was cooled to an internal temperature of -63 °C. Methylmagnesium bromide (3M THF solution, 35 mL, 105 mmol) was added slowly over 30 minutes. After addition, the reaction mixture was continued to be stirred at -60 °C for 45 min, followed by slow warming to room temperature. THF (50 mL) was added to dissolve any precipitate that may have formed and the reaction mixture was stirred for 1 hour. Subsequently, 2M aqueous hydrochloric acid (100 mL) was added and stirring was continued for 4 hours. The pH of the reaction mixture was adjusted with aqueous sodium bicarbonate to 7. The organic and aqueous phases were separated and the product was extracted from the aqueous phase with dichloromethane (DCM). The organic extracts were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by fast column chromatography (eluent: heptane/ethyl acetate gradient) to afford 7.9 g (64% yield) of 1-(5-chloropyridin-2-yl)ethanone.1H NMR (300 MHz, CDCl3) δ ppm: 8.62 (m, 1H), 8.00 (m, 1H), 7.80 (m, 1H), 2.70 (s, 3H).
References
[1] Patent: WO2008/39139, 2008, A1. Location in patent: Page/Page column 26
[2] Patent: WO2008/39138, 2008, A1. Location in patent: Page/Page column 28
1-(5-CHLOROPYRIDIN-2-YL)ETHANONE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zepeptide Biotechnology (Shijiazhuang) Co., Ltd | +86-86-13383293380 +8613230482270 | 1919301810@qq.com | China | 141 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29792 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 | marketing1@neostarunited.com | China | 8828 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8618071025641 | eric@witopchemical.com | China | 23541 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29093 | 58 |
View Lastest Price from 1-(5-CHLOROPYRIDIN-2-YL)ETHANONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | 1-(5-CHLOROPYRIDIN-2-YL)ETHANONE
94952-46-2
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2019-12-26 | 1-(5-CHLOROPYRIDIN-2-YL)ETHANONE
94952-46-2
|
$1.00 | 1KG | 99% | 1000KGS | Career Henan Chemical Co |
-
- 1-(5-CHLOROPYRIDIN-2-YL)ETHANONE
94952-46-2
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 1-(5-CHLOROPYRIDIN-2-YL)ETHANONE
94952-46-2
- $1.00
- 99%
- Career Henan Chemical Co
