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ChemicalBook >> CAS DataBase List >>Spiro[3H-indole-3,4'-[4H]thiopyran]-5-carboxamide, N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydro-, 1',1'-dioxide, (2R)-

Spiro[3H-indole-3,4'-[4H]thiopyran]-5-carboxamide, N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydro-, 1',1'-dioxide, (2R)-

Spiro[3H-indole-3,4'-[4H]thiopyran]-5-carboxamide, N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydro-, 1',1'-dioxide, (2R)- Structure
Spiro[3H-indole-3,4'-[4H]thiopyran]-5-carboxamide, N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydro-, 1',1'-dioxide, (2R)- structure
CAS No.
1631164-25-4
Chemical Name:
Spiro[3H-indole-3,4'-[4H]thiopyran]-5-carboxamide, N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydro-, 1',1'-dioxide, (2R)-
Synonyms
BAY-786;(R)-N-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)methyl)-2-cyclopropyl-1-((4-fluorophenyl)sulfonyl)-;(2R)-N-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran]-5-carboxamide 1',1'-dioxide;Spiro[3H-indole-3,4'-[4H]thiopyran]-5-carboxamide, N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydro-, 1',1'-dioxide, (2R)-
CBNumber:
CB58204182
Molecular Formula:
C29H26ClF4N3O5S2
Molecular Weight:
672.11
MDL Number:
MOL File:
1631164-25-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-21 10:31:43
Request For Quotation

Spiro[3H-indole-3,4'-[4H]thiopyran]-5-carboxamide, N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydro-, 1',1'-dioxide, (2R)- Properties

Density 1.60±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 2mg/mL, clear
pka 12.47±0.40(Predicted)
form powder
color white to beige
optical activity [α]/D 105 to 125°, c =0.5 in chloroform-d
InChIKey PZGSYNNVPNLHQG-AREMUKBSSA-N
SMILES O=C(C1=CC2=C(N(S(=O)(C3=CC=C(F)C=C3)=O)[C@H](C4CC4)C2(CC5)CCS5(=O)=O)C=C1)NCC6=NC=C(C(F)(F)F)C=C6Cl
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

Spiro[3H-indole-3,4'-[4H]thiopyran]-5-carboxamide, N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydro-, 1',1'-dioxide, (2R)- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML3026 BAY-786 ≥98% (HPLC) 1631164-25-4 5MG $125 2026-04-30 Buy
Sigma-Aldrich SML3026 BAY-786 ≥98% (HPLC) 1631164-25-4 25MG $504 2026-04-30 Buy
ChemScene CS-0435627 BAY 1214784 99.8% 1631164-25-4 1mg $119 2026-06-04 Buy
ChemScene CS-0435627 BAY 1214784 99.8% 1631164-25-4 5mg $297 2026-06-04 Buy
aablocks AA024G3M BAY 1214784 >98% 1631164-25-4 1mg $158 2026-06-01 Buy
Product number Packaging Price Buy
SML3026 5MG $125 Buy
SML3026 25MG $504 Buy
CS-0435627 1mg $119 Buy
CS-0435627 5mg $297 Buy
AA024G3M 1mg $158 Buy

Spiro[3H-indole-3,4'-[4H]thiopyran]-5-carboxamide, N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydro-, 1',1'-dioxide, (2R)- Chemical Properties, Uses, Production

Uses

BAY 1214784 is a potent, selective, and orally active antagonist of the human gonadotropin-releasing hormone receptor (hGnRH-R). BAY 1214784 is a spiroindoline derivative compound. BAY 1214784 effectively lowers plasma luteinizing hormone levels by up to 49%, at the same time being associated with low pharmacokinetic variability and good tolerability. BAY 1214784 has the potential for the research of uterine fibroids[1].

Biological Activity

BAY-786 is a negative control for an orally available, non-toxic, potent, and selective GnRH-R antagonist BAY-784.

References

[1] Panknin O, et al. Discovery and Characterization of BAY 1214784, an Orally Available Spiroindoline Derivative Acting as a Potent and Selective Antagonist of the Human Gonadotropin-Releasing Hormone Receptor as Proven in a First-In-Human Study in Postmenop DOI:10.1021/acs.jmedchem.0c01076

Spiro[3H-indole-3,4'-[4H]thiopyran]-5-carboxamide, N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydro-, 1',1'-dioxide, (2R)- Preparation Products And Raw materials

Raw materials

Preparation Products

Spiro[3H-indole-3,4'-[4H]thiopyran]-5-carboxamide, N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydro-, 1',1'-dioxide, (2R)- Suppliers

Global Suppliers ( 7)
Supplier Tel Email Country ProdList Advantage
https://hanhongsci.com/ 021-54306202 18917919676 info@hanhongsci.com China 29982 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Guangzhou Ruidi Biotechnology Co., Ltd. 020-82099279 18988941402 sales@ubiochem.com China 9998 58
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 ivan@atkchemical.com China 32997 60
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
https://hanhongsci.com/ 58
TargetMol Chemicals Inc. 58
Guangzhou Ruidi Biotechnology Co., Ltd. 58
ATK CHEMICAL COMPANY LIMITED 60
TargetMol Chemicals Inc. 58

View Latest Price from Spiro[3H-indole-3,4'-[4H]thiopyran]-5-carboxamide, N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydro-, 1',1'-dioxide, (2R)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BAY 1214784 pictures 2026-04-20 BAY 1214784
1631164-25-4
 $558.00-1080.00 100.00% 10g TargetMol Chemicals Inc.
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  • BAY 1214784
    1631164-25-4
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1631164-25-4 (Spiro[3H-indole-3,4'-[4H]thiopyran]-5-carboxamide, N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydro-, 1',1'-dioxide, (2R)-) Related Search:

BAY-784 Spiro[3H-indole-3,4'-[4H]thiopyran]-5-carboxamide, N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydro-, 1',1'-dioxide, (2R)- Kisspeptin 13 TFA FSH RECEPTOR-BINDING INHIBITOR FRAGMENT (BI-10) FERTIRELIN
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Spiro[3H-indole-3,4'-[4H]thiopyran]-5-carboxamide, N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydro-, 1',1'-dioxide, (2R)- (R)-N-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)methyl)-2-cyclopropyl-1-((4-fluorophenyl)sulfonyl)- (2R)-N-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran]-5-carboxamide 1',1'-dioxide BAY-786 1631164-25-4 C29H26ClF4N3O5S2