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(1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID

(1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID structure

CAS No.: 13570-08-6

Chemical Name:: (1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID

Synonyms: 2-BENZIMIDAZOLEACETIC ACID;1H-BENZIMIDAZOL-2-YLACETIC ACID;2-(1H-benzo[d]imidazol-2-yl)acetic acid;NSC 525202;AKOS BBS-00002502;RARECHEM AK ML 0141;IFLAB-BB F1727-0259;CHEMBRDG-BB 4400292;Benzimidazole-2-acetic acid;2-Benzimidazolylacetic acid

CBNumber:: CB5838729

Molecular Formula:: C9H8N2O2

Molecular Weight:: 176.17

MDL Number:: MFCD01102656

MOL File:: 13570-08-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 04:47:00

Product description	Number	Pack Size	Price
(1H-Benzoimidazol-2-Yl)-Acetic Acid Asreported	265672	50mg	$333
(1H-Benzoimidazol-2-Yl)-Acetic Acid Asreported	265672	100mg	$456
(1H-Benzoimidazol-2-Yl)-Acetic Acid Asreported	265672	250mg	$563
(1H-Benzoimidazol-2-Yl)-Acetic Acid Asreported	265672	500mg	$736
(1H-Benzoimidazol-2-Yl)-Acetic Acid Asreported	265672	1g	$1150
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(1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID Properties

Melting point	116 °C
Boiling point	498.3±28.0 °C(Predicted)
Density	1.437±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	1.54±0.30(Predicted)
Appearance	Light yellow to light brown Solid
EWG's Food Scores	1
FDA UNII	DJU8LFP9EA

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H311+H331-H302
Precautionary statements	P501-P261-P270-P271-P264-P280-P361+P364-P301+P312+P330-P302+P352+P312-P304+P340+P311-P403+P233-P405
Hazard Codes	Xi
HazardClass	IRRITANT

(1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID price More Price(60)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	265672	(1H-Benzoimidazol-2-Yl)-Acetic Acid Asreported	13570-08-6	50mg	$333	2026-06-03	Buy
Usbiological	265672	(1H-Benzoimidazol-2-Yl)-Acetic Acid Asreported	13570-08-6	100mg	$456	2026-06-03	Buy
Usbiological	265672	(1H-Benzoimidazol-2-Yl)-Acetic Acid Asreported	13570-08-6	250mg	$563	2026-06-03	Buy
Usbiological	265672	(1H-Benzoimidazol-2-Yl)-Acetic Acid Asreported	13570-08-6	500mg	$736	2026-06-03	Buy
Usbiological	265672	(1H-Benzoimidazol-2-Yl)-Acetic Acid Asreported	13570-08-6	1g	$1150	2026-06-03	Buy

Product number	Packaging	Price	Buy
265672	50mg	$333	Buy
265672	100mg	$456	Buy
265672	250mg	$563	Buy
265672	500mg	$736	Buy
265672	1g	$1150	Buy

(1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID Chemical Properties,Uses,Production

Uses

(1h-Benzoimidazol-2-yl)-acetic Acid is a useful intermediate for the synthesis of benzisothiazole/benzimidazole derivatives with acidic groups that exhibits numerous pharmacological properties.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 36, p. 1746, 1993 DOI: 10.1021/jm00064a008

Synthesis

4414-88-4

13570-08-6

General procedure for the synthesis of benzimidazole-2-acetic acid from 2-cyanomethylbenzimidazole: A mixture of 1 g of 2-cyanomethylbenzimidazole (3a-b) with 2 ml of 37% aqueous hydrochloric acid in the presence of 1 ml of benzenesulphonic acid was heated and stirred under reflux conditions for 4-5 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was cooled to room temperature and extracted with ether (3 x 30 ml), followed by removal of solvent by distillation under reduced pressure to afford the target products benzimidazole-2-acetic acid (4a-b). 4.3.1. 1H-benzimidazole-2-acetic acid (4a, C9H8N2O2) was a green solid, hygroscopic, with a yield of 81% and a melting point of 240-242 °C; TLC Rf value of 0.42 [unfolding reagent ratio of toluene: ethyl acetate: formic acid (5:4:1)]; IR spectra (KBr, cm^-1 ): 3624 (O-H telescoping vibration) 3230 (N-H stretching vibration), 1722 (C=O stretching vibration); 1H NMR (300MHz, DMSO-d6) δ (ppm): 3.64 (single peak, 2H, CH2COOH), 7.58 (double peaks, 2H, J=7.5,0.9Hz, H-5,6 on benzimidazole ring), 7.92 (double peaks, 2H, J=7.5 Hz, H-4,7 on the benzimidazole ring), 10.59 (broad peak, 1H, COOH), 12.03 (broad peak, 1H, NH).13C NMR (75 MHz, DMSO-d6) δ (ppm): 164.20, 152.20, 131.95, 128.32, 122.50, 48.40. Calculated values for elemental analysis (%) : C, 61.36; H, 4.58; N, 15.90; measured values (%): C, 61.33; H, 4.56; N, 15.92.

References

[1] Patent: US5792768, 1998, A
[2] Farmaco, 2002, vol. 57, # 5, p. 363 - 367
[3] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 853 - 869
[4] Journal of Medicinal Chemistry, 1993, vol. 36, # 12, p. 1746 - 1753
[5] Patent: WO2017/68089, 2017, A2. Location in patent: Page/Page column 243

(1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID Preparation Products And Raw materials

Raw materials

2-(Cyanomethyl)benzimidazole Benzenesulfonic acid Hydrochloric acid

Preparation Products

1H-Benzimidazole-2-aceticacid,methylester(9CI)

(1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID Suppliers

Global( 114)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	16512	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Xiamen Shindano Biotechnology Co.,ltd	0592-6266840 15750707980	sales@chemsdano.com	China	291	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19936	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Shenzhen Excellent Biotech Co., Ltd.	13480692018	ramyan@ex-biotech.com	CHINA	954	58
Jurong Coupling Biotechnology Co., Ltd.	13656108824	coupling278191416@hotmail.com	CHINA	184	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5742	58

Supplier	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Xiamen Shindano Biotechnology Co.,ltd	58
BOC Sciences	58
Alchem Pharmtech,Inc.	58
Shenzhen Excellent Biotech Co., Ltd.	58
Jurong Coupling Biotechnology Co., Ltd.	58
career henan chemical co	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58

View Lastest Price from (1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-17	(1H-benzoimidazol-2-yl)acetic acid 13570-08-6	$1.60-6.60	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2022-01-26	1H-benzoimidazol-2-yl)acetic acid 13570-08-6		1KG	98.2%	100 tons	Honest Joy Holdings Limited
2020-01-13	(1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID 13570-08-6	$5.00	1KG	98%	100KG	Career Henan Chemical Co

(1H-benzoimidazol-2-yl)acetic acid
13570-08-6
$1.60-6.60
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

1H-benzoimidazol-2-yl)acetic acid
13570-08-6
$0.00
98.2%
Honest Joy Holdings Limited

(1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID
13570-08-6
$5.00
98%
Career Henan Chemical Co

(1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID Spectrum

(1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID(13570-08-6)¹HNMR

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CHEMBRDG-BB 4400292 IFLAB-BB F1727-0259 (1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID AKOS BBS-00002502 RARECHEM AK ML 0141 1H-Benzimidazole-2-aceticacid(9CI) 1H-Benzimidazole-2-acetic acid 1H-benzimidazol-2-ylacetic acid(SALTDATA: FREE) 2-(1H-1H-benzo[d]iMidazol-2-yl)-acetic acid 2-(2-Benzoimidazolyl)acetic Acid Benzimidazole-2-acetic acid 2-(1H-benzimidazol-2-yl)acetic acid 2-(1H-benzimidazol-2-yl)ethanoic acid 2-(1H-benzimidazol-3-ium-2-yl)acetate 2-(1H-benzimidazol-3-ium-2-yl)ethanoate 2-(Carboxymethyl)benzimidazole Acetic acid, 2-benzimidazol-2-yl- 2-Benzimidazolylacetic acid NSC 525202 1H-Benzimidazole-2-acetic acid (9CI, ACI) 1H-BENZIMIDAZOL-2-YLACETIC ACID 2-(1H-benzo[d]imidazol-2-yl)acetic acid 2-BENZIMIDAZOLEACETIC ACID 13570-08-6 BENZIMIDAZOLE Carboxylic Acids Imidazoles & Benzimidazoles Carboxylic Acids Imidazoles & Benzimidazoles