(1H-Benzoimidazol-2-yl)-acetic acid
- CAS No.
- 13570-08-6
- Chemical Name:
- (1H-Benzoimidazol-2-yl)-acetic acid
- Synonyms
- 2-BENZIMIDAZOLEACETIC ACID;1H-BENZIMIDAZOL-2-YLACETIC ACID;2-(1H-benzo[d]imidazol-2-yl)acetic acid;NSC 525202;AKOS BBS-00002502;RARECHEM AK ML 0141;IFLAB-BB F1727-0259;CHEMBRDG-BB 4400292;Benzimidazole-2-acetic acid;2-Benzimidazolylacetic acid
- CBNumber:
- CB5838729
- Molecular Formula:
- C9H8N2O2
- Molecular Weight:
- 176.17
- MDL Number:
- MFCD01102656
- MOL File:
- 13570-08-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 116 °C |
|---|---|
| Boiling point | 498.3±28.0 °C(Predicted) |
| Density | 1.437±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 1.54±0.30(Predicted) |
| Appearance | Light yellow to light brown Solid |
| EWG's Food Scores | 1 |
| FDA UNII | DJU8LFP9EA |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H311+H331-H302 |
| Precautionary statements | P501-P261-P270-P271-P264-P280-P361+P364-P301+P312+P330-P302+P352+P312-P304+P340+P311-P403+P233-P405 |
| Hazard Codes | Xi |
| HazardClass | IRRITANT |
(1H-Benzoimidazol-2-yl)-acetic acid price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 265672 | (1H-Benzoimidazol-2-Yl)-Acetic Acid Asreported | 13570-08-6 | 50mg | $333 | 2026-06-03 | Buy |
| Usbiological | 265672 | (1H-Benzoimidazol-2-Yl)-Acetic Acid Asreported | 13570-08-6 | 100mg | $456 | 2026-06-03 | Buy |
| Usbiological | 265672 | (1H-Benzoimidazol-2-Yl)-Acetic Acid Asreported | 13570-08-6 | 250mg | $563 | 2026-06-03 | Buy |
| Usbiological | 265672 | (1H-Benzoimidazol-2-Yl)-Acetic Acid Asreported | 13570-08-6 | 500mg | $736 | 2026-06-03 | Buy |
| Usbiological | 265672 | (1H-Benzoimidazol-2-Yl)-Acetic Acid Asreported | 13570-08-6 | 1g | $1150 | 2026-06-03 | Buy |
(1H-Benzoimidazol-2-yl)-acetic acid Chemical Properties, Uses, Production
Uses
(1h-Benzoimidazol-2-yl)-acetic Acid is a useful intermediate for the synthesis of benzisothiazole/benzimidazole derivatives with acidic groups that exhibits numerous pharmacological properties.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 36, p. 1746, 1993 DOI: 10.1021/jm00064a008
Synthesis
4414-88-4
13570-08-6
General procedure for the synthesis of benzimidazole-2-acetic acid from 2-cyanomethylbenzimidazole: A mixture of 1 g of 2-cyanomethylbenzimidazole (3a-b) with 2 ml of 37% aqueous hydrochloric acid in the presence of 1 ml of benzenesulphonic acid was heated and stirred under reflux conditions for 4-5 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was cooled to room temperature and extracted with ether (3 x 30 ml), followed by removal of solvent by distillation under reduced pressure to afford the target products benzimidazole-2-acetic acid (4a-b). 4.3.1. 1H-benzimidazole-2-acetic acid (4a, C9H8N2O2) was a green solid, hygroscopic, with a yield of 81% and a melting point of 240-242 °C; TLC Rf value of 0.42 [unfolding reagent ratio of toluene: ethyl acetate: formic acid (5:4:1)]; IR spectra (KBr, cm^-1 ): 3624 (O-H telescoping vibration) 3230 (N-H stretching vibration), 1722 (C=O stretching vibration); 1H NMR (300MHz, DMSO-d6) δ (ppm): 3.64 (single peak, 2H, CH2COOH), 7.58 (double peaks, 2H, J=7.5,0.9Hz, H-5,6 on benzimidazole ring), 7.92 (double peaks, 2H, J=7.5 Hz, H-4,7 on the benzimidazole ring), 10.59 (broad peak, 1H, COOH), 12.03 (broad peak, 1H, NH).13C NMR (75 MHz, DMSO-d6) δ (ppm): 164.20, 152.20, 131.95, 128.32, 122.50, 48.40. Calculated values for elemental analysis (%) : C, 61.36; H, 4.58; N, 15.90; measured values (%): C, 61.33; H, 4.56; N, 15.92.
References
[1] Patent: US5792768, 1998, A
[2] Farmaco, 2002, vol. 57, # 5, p. 363 - 367
[3] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 853 - 869
[4] Journal of Medicinal Chemistry, 1993, vol. 36, # 12, p. 1746 - 1753
[5] Patent: WO2017/68089, 2017, A2. Location in patent: Page/Page column 243
(1H-Benzoimidazol-2-yl)-acetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16306 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3997 | 55 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| shanghai cooperpharm co.,LTD . | +86-021-58975553 | sales@cooperpharm.com | China | 1210 | 56 |
View Latest Price from (1H-Benzoimidazol-2-yl)-acetic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | (1H-benzoimidazol-2-yl)acetic acid
13570-08-6
|
$1.60-6.60 | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2022-01-26 | 1H-benzoimidazol-2-yl)acetic acid
13570-08-6
|
1KG | 98.2% | 100 tons | Honest Joy Holdings Limited | ||
 |
2020-01-13 | (1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID
13570-08-6
|
$5.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- (1H-benzoimidazol-2-yl)acetic acid
13570-08-6
- $1.60-6.60
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 1H-benzoimidazol-2-yl)acetic acid
13570-08-6
- $0.00
- 98.2%
- Honest Joy Holdings Limited
-
- (1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID
13570-08-6
- $5.00
- 98%
- Career Henan Chemical Co
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