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4-Aminoacetophenone

4-Aminoacetophenone Structure
4-Aminoacetophenone structure
CAS No.
99-92-3
Chemical Name:
4-Aminoacetophenone
Synonyms
1-(4-AMINOPHENYL)ETHAN-1-ONE;1-(4-AMINOPHENYL)ETHANONE;P-AMINOACETOPHENONE;4-ACETYLANILINE;Clenbuterol EP Impurity D;p-Acetylaniline;P-AMINOACETYLBENZENE;1-(4-aminophenyl)-ethanon;NSC 3242;usafek-631
CBNumber:
CB9299995
Molecular Formula:
C8H9NO
Molecular Weight:
135.16
MDL Number:
MFCD00007896
MOL File:
99-92-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 06:26:48
Product description Number Pack Size Price
4′-Aminoacetophenone 99% A38002 25g $52.5
4′-Aminoacetophenone 99% A38002 100g $124
4'-Aminoacetophenone >98.0%(T) A0251 25g $63
4'-Aminoacetophenone >98.0%(T) A0251 100g $186
4-Aminoacetophenone TRC-A580075-25G 25g $83
More product size
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4-Aminoacetophenone Properties

Melting point 103-107 °C(lit.)
Boiling point 293 °C(lit.)
Density 0,77 g/cm
bulk density 580kg/m3
refractive index 1.5700 (estimate)
Flash point 292-294°C
storage temp. Store below +30°C.
solubility 6.5g/l
form Crystalline Powder
pka 2.17±0.10(Predicted)
Specific Gravity 0.77
color Slightly yellow to brown
Water Solubility It is soluble in hot water, ethanol and ether.
Merck 14,413
BRN 471493
Henry's Law Constant 2.2×103 mol/(m3Pa) at 25℃, HSDB (2015)
InChI 1S/C8H9NO/c1-6(10)7-2-4-8(9)5-3-7/h2-5H,9H2,1H3
InChIKey GPRYKVSEZCQIHD-UHFFFAOYSA-N
SMILES CC(=O)c1ccc(N)cc1
LogP 0.830
CAS DataBase Reference 99-92-3(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 1S58KH902I
NIST Chemistry Reference Acetophenone, 4'-amino-(99-92-3)
EPA Substance Registry System 4'-Aminoacetophenone (99-92-3)
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38-20/21/22
Safety Statements  26-36
WGK Germany  3
RTECS  AM5500000
TSCA  TSCA listed
HazardClass  IRRITANT-HARMFUL
HS Code  29223900
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Hazardous Substances Data 99-92-3(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: 381 mg/kg
NFPA 704
1
2 0

4-Aminoacetophenone price More Price(96)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A38002 4′-Aminoacetophenone 99% 99-92-3 25g $52.5 2026-04-30 Buy
Sigma-Aldrich A38002 4′-Aminoacetophenone 99% 99-92-3 100g $124 2026-04-30 Buy
TCI Chemical A0251 4'-Aminoacetophenone >98.0%(T) 99-92-3 25g $63 2026-04-30 Buy
TCI Chemical A0251 4'-Aminoacetophenone >98.0%(T) 99-92-3 100g $186 2026-04-30 Buy
TRC TRC-A580075-25G 4-Aminoacetophenone 99-92-3 25g $83 2026-06-03 Buy
Product number Packaging Price Buy
A38002 25g $52.5 Buy
A38002 100g $124 Buy
A0251 25g $63 Buy
A0251 100g $186 Buy
TRC-A580075-25G 25g $83 Buy

4-Aminoacetophenone Chemical Properties,Uses,Production

Description

4-Aminoacetophenone is in the form of yellow needle-like crystals, with a melting point of 106°C, a boiling point of 293-295°C, and 195-200°C (2kPa). Soluble in hot water, soluble in alcohol, ether, dilute hydrochloric acid and dilute sulfuric acid, it is slightly soluble in benzene and cold water. Has a special pleasant fragrance. It can be used as a pharmaceutical intermediate.
4-Aminoacetophenone

Synthesis

Through a Williamson ether synthesis method and Smiles rearrangement reaction, benzamide compounds are produced, then the 4-aminoacetophenone preparation is finished after hydrolysis. 

Applications

4′-Aminoacetophenone, is used in pharmaceuticals, medicines and other organic products. It is also used as a reagent for the photometric determination of Ce. As pharmaceutical intemediate or in the determination of palladium and vitaminB1.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. acids, Incompatible to Acid chlorides, Acid anhydrides, Chloroformates, Strong oxidizing agents, Strong reducing agents. Stable under ordinary conditions.

Chemical Properties

slightly yellow to brown crystalline powder

Uses

4'-Aminoacetophenone, is used in pharmaceuticals, medicines and other organic products. It is also used as a reagent for the photometric determination of Ce. As pharmaceutical intemediate or in the determination of palladium and vitaminB1.

Uses

4-Aminoacetophenone is a novel utilization of aminophenone derivative in toxicology used for treating intoxications with cyanogenic toxic substances.

Uses

4-Aminoacetophenone can be used as an organic reagent to synthesize a variety of organic substances, which is used in the field of anticancer drug preparation and analytical detection. Using it as a raw material, Schiff alkali palladium(II) complexes (cyclopalladiumated compounds) are synthesized by combining metals with carbon atoms. The drug inhibits and kills invasive melanoma cancer cell line (MDA-MB-435)[1]. Hydroxylamine hydrochloride and 4-aminoacetophenone synthesize 4-aminoacetophenone oxime (APO) by oximation reaction, which has a high sensitivity to Organophosphorus (OP）nerve agent mimic-diethylcyanophosphonate. APO can be used to prepare electrochemical sensors with high sensitivity and selectivity to detect OPs[2].

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 34, p. 2013, 1986 DOI: 10.1248/cpb.34.2013
Tetrahedron Letters, 27, p. 4687, 1986 DOI: 10.1016/S0040-4039(00)85038-8

General Description

4′-Aminoacetophenone, commonly known as Clenbuterol Impurity D, is a related compound of sympathomimetic amine drug clenbuterol. Clenbuterol belongs to a group of compounds referred to as β-2-agonists and is generally used in the treatment of asthma.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Safety Profile

Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NO,. See also AROMATIC AMINES

Purification Methods

It is soluble in hot H2O. UV (EtOH) has max 403nm (log 4.42) [Johnson J Am Chem Soc 75 2720 1953]. [Vandenbelt Anal Chem 26 726 1954.] The 2,4-dinitrophenylhydrazone has m 266-267o (from CHCl3 or EtOH) with 403nm (log 4.42), and the max semicarbazone has m 193-194o(dec)(from MeOH). The hydrochloride has m 98o(dec)(from H2O). [Beilstein 14 IV 100.]

Toxicity evaluation

Harmful if swallowed. Causes eye, skin, and respiratory tract irritation. May cause methemoglobinemia.

References

[1] SARTO& L, et al. Anticancer Potential of Palladium(II) Complexes With Schiff Bases Derived from 4-Aminoacetophenone Against Melanoma In Vitro. Anticancer Research, 2019; 39.
[2] Huixiang W, et al. A non-enzymatic electro-chemical sensor for organophosphorus nerve agents mimics and pesticides detections. Organic Electronics, 2017; 252: 1118-1124.

4-Aminoacetophenone synthesis

100-19-6
99-92-3
589-16-2
Synthesis of 4-Aminoacetophenone from 4-Nitroacetophenone

4-Aminoacetophenone Preparation Products And Raw materials

Raw materials

Stannous chloride dihydrate 2-BENZOYLACETANILIDE Ethanol Zinc chloride 4-Nitroacetophenone
Decolorizing charcoal Aniline Acetanilide 4',4'''-Azobisacetophenone 4-ETHYNYLANILINE
P-AZIDOACETOPHENONE 4-Ethylaniline 4-AMINOACETOPHENONE OXIME 4'-Bromoacetophenone 4'-Chloroacetophenone

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Preparation Products

4-Amino-3,5-dichloroacetophenone Asthma ACETOHEXAMIDE 4'-(IMIDAZOL-1-YL)ACETOPHENONE Direct Red 23
4'-Iodoacetophenone 4-(1H-INDOL-2-YL)-PHENYLAMINE 4'-Hydroxyacetophenone 4-AMINO-ALPHA-TERT-BUTYLAMINE-3,5-DICHLOROACETOPHENONE 1-(4-AMINO-3-CHLORO-PHENYL)-ETHANONE
Carbamic acid, N-(4-acetylphenyl)-, methyl ester NISTC4150372

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4-Aminoacetophenone Suppliers

Global( 655)Suppliers
Supplier Tel Email Country ProdList Advantage
Jinan Finer Chemical Co., Ltd
+86-531-88989536 +86-15508631887 sales@finerchem.com China 2950 58
Shijiazhuang Jianxin Biotechnology Co., LTD
+undefined-86-1906231316-9 +undefined86-19062313169 liyingjian1997@gmail.com China 712 58
RongNa Biotechnology Co.,Ltd
+86-86-13583358881 +8618560316533 Brad@rongnabiotech.com China 3372 58
Ningbo Banco Chemical Technology Co., Ltd.
+86-15827200700 sales@bancochemical.com China 487 58
Shaanxi Dideu Medichem Co. Ltd 		+8617392709771 1097@dideu.com China 3991 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Shanghai UCHEM Inc. 		+862156762820 +86-13564624040 sales@myuchem.com China 8834 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 +8613131129325 sales1@chuanghaibio.com China 5220 58
Shanghai Qyubiotech Co., Ltd. 		+86-086-021-37596619 +8618019359838 info@qyubiotech.com China 307 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Supplier Advantage
Jinan Finer Chemical Co., Ltd
58
Shijiazhuang Jianxin Biotechnology Co., LTD
58
RongNa Biotechnology Co.,Ltd
58
Ningbo Banco Chemical Technology Co., Ltd.
58
Shaanxi Dideu Medichem Co. Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Shanghai UCHEM Inc. 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Shanghai Qyubiotech Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58

Related articles

View Lastest Price from 4-Aminoacetophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Aminoacetophenone pictures 2026-07-19 4-Aminoacetophenone
99-92-3
 $1.00 1G 99.9% 10000KG .GZ HONESTCHEM CO.,LTD
Ethanone, 1-(4-aminophenyl)- pictures 2026-07-19 Ethanone, 1-(4-aminophenyl)-
$1.00 1G 99.9% 10000KG .GZ HONESTCHEM CO.,LTD
1-(4-aminophenyl)ethanone pictures 2026-07-19 1-(4-aminophenyl)ethanone
$1.00 1G 99.9% 10000KG .GZ HONESTCHEM CO.,LTD

4-Aminoacetophenone Spectrum

4-Aminoacetophenone(99-92-3)MS4-Aminoacetophenone(99-92-3)1HNMR4-Aminoacetophenone(99-92-3)13CNMR4-Aminoacetophenone(99-92-3)IR14-Aminoacetophenone(99-92-3)IR24-Aminoacetophenone(99-92-3)IR34-Aminoacetophenone(99-92-3)Raman

99-92-3(4-Aminoacetophenone)Related Search:

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