6-Methylisoquinoline
- CAS No.
- 42398-73-2
- Chemical Name:
- 6-Methylisoquinoline
- Synonyms
- 3,4,4-trimethylpentan-2-one;6-Methylisoquinoline;Isoquinoline, 6-methyl-;6-Methylisoquinoline 98%;6-Methylisoquinoline ,98%;6-Methylisoquinoline ISO 9001：2015 REACH
- CBNumber:
- CB5879955
- Molecular Formula:
- C10H9N
- Molecular Weight:
- 143.19
- MDL Number:
- MFCD09258767
- MOL File:
- 42398-73-2.mol
| Melting point | 85.5°C |
|---|---|
| Boiling point | 246.29°C (estimate) |
| Density | 1.0584 (estimate) |
| refractive index | 1.6103 (estimate) |
| pka | 5.85±0.10(Predicted) |
| form | solid |
| color | Beige |
| InChI | InChI=1S/C10H9N/c1-8-2-3-10-7-11-5-4-9(10)6-8/h2-7H,1H3 |
| InChIKey | PPEJLOXOMBAXES-UHFFFAOYSA-N |
| SMILES | C1C2=C(C=C(C)C=C2)C=CN=1 |
| CAS DataBase Reference | 42398-73-2(CAS DataBase Reference) |
| FDA UNII | 3ZAG75WYA8 |
| UNSPSC Code | 12352210 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P264-P280-P261-P271-P302+P352-P332+P313-P362+P364-P305+P351+P338-P337+P313-P304+P340-P312-P403+P233-P405-P501 |
| Hazard Codes | Xi |
| Risk Statements | 36 |
| Safety Statements | 26-24/25 |
| WGK Germany | WGK 3 |
| Hazard Note | Irritant |
| HS Code | 29334900 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 4 Oral Aquatic Chronic 3 Eye Irrit. 2 Skin Irrit. 2 |
6-Methylisoquinoline price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS017224 | 6-methylisoquinoline AldrichCPR | 42398-73-2 | 25 mg | $77.9 | 2026-04-30 | Buy |
| AstaTech | 64314 | 6-METHYLISOQUINOLINE 97% | 42398-73-2 | 1G | $27 | 2026-04-30 | Buy |
| AstaTech | 64314 | 6-METHYLISOQUINOLINE 97% | 42398-73-2 | 5G | $77 | 2026-04-30 | Buy |
| AstaTech | 64314 | 6-METHYLISOQUINOLINE 97% | 42398-73-2 | 10G | $133 | 2026-04-30 | Buy |
| Apolloscientific | OR8565 | 6-Methylisoquinoline 98% | 42398-73-2 | 100mg | $21 | 2026-06-04 | Buy |
6-Methylisoquinoline Chemical Properties,Uses,Production
Chemical Properties
Light beige powder
Uses
6-Methylisoquinoline (cas# 42398-73-2) is a useful reagent for the green preparation of polyfluoroarylated heterocyclic compounds.
Preparation
A benzene solution (50 ml, CAUTION) of equimolar amounts of p-tolualdehyde (8.4 g, 0.07 mol) and aminoacetaldehyde dimethyl acetal (7.35 g, 0.07 mol) is refluxed overnight into a Dean and Stark trap. The solution is evaporated in vacuo and then twice evaporated again with added benzene and the viscous oil dissolved in dry tetrahydrofuran. This solution is cooled to - 10 °C and 1 equivalent of ethyl chloroformate (7. 1 ml, 0.07 mol) is added with rapid stirring and the mixture stirred for a further 5 minutes. The cooling bath is removed and 1.2 equivalents of trimethyl phosphite ( 10.5 ml, 0.09 mol) is added with stirring. The solution is stirred at room temperature for 1 5 hours and then evaporated t o an oil. The oil is then re-evaporated twice with added toluene to remove traces of trimethyl phosphite. The oil is dissolved in dry dichloromethane, 6 equivalents of titanium(1v) chloride (50 ml, 0.45 mol) is added and the solution refluxed for 36 hours under a drying tube. The cooled solution is shaken with 1 equivalent of aqueous sodium hydroxide solution to neutrality, whereupon titanium(1v) oxide precipitates as a white solid. The filtered organic layer is extracted with 3 M hydrochloric acid, and the extract is washed with dichloromethane, basified strongly with aqueous alkali, and extracted with dichloromethane. This organic extract is dried over anhydrous sodium sulphate and evaporated to afford 6-methylisoquinoline (yield 7 1 %, m.p. 88 °C).
Synthesis Reference(s)
The Journal of Organic Chemistry, 48, p. 3344, 1983 DOI: 10.1021/jo00167a043
6-Methylisoquinoline Preparation Products And Raw materials
Raw materials
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Preparation Products
6-Methylisoquinoline Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tongchuang Pharma(Suzhou). Co., Ltd. | 0512-63263366 18912765016 | tongtf110@sina.com | China | 984 | 62 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| HANSHANG CHEMICAL SCIENTIFIC LIMITED | 021-50521775 15800962688 | sales@hanshangchem.com | China | 471 | 57 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 |
View Lastest Price from 6-Methylisoquinoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 6-Methylisoquinoline
42398-73-2
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2020-01-19 | 6-Methylisoquinoline
42398-73-2
|
$3.00 | 1KG | 98% | 1kg,5kg,50kg | Career Henan Chemical Co | |
 |
2020-01-15 | 6-Methylisoquinoline
5340-45-5
|
$1.00 | 1KG | 98% | 1KG, 5KG, 50KG | Career Henan Chemical Co |
-
- 6-Methylisoquinoline
42398-73-2
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 6-Methylisoquinoline
42398-73-2
- $3.00
- 98%
- Career Henan Chemical Co
-
- 6-Methylisoquinoline
5340-45-5
- $1.00
- 98%
- Career Henan Chemical Co
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