8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
- CAS No.
- 22316-55-8
- Chemical Name:
- 8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
- Synonyms
- Clofazin;Norclobazam;Einecs 244-909-2;Demethylclobazam;Desmethylclobazam;N-Demethylclobazam;Clobazam EP Impurity A;N-Desmethylclobazam (CRM);Clobazam Related Compound A;N-Desmethylclobazam solution
- CBNumber:
- CB5921872
- Molecular Formula:
- C15H11ClN2O2
- Molecular Weight:
- 286.71
- MDL Number:
- MFCD00871860
- MOL File:
- 22316-55-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| N-Desmethylclobazam solution 1.0?mg/mL (acetonitrile:DMSO (90:10 v/v)), ampule of 1?mL, certified reference material, Cerilliant? | D-145 | 1ML | $435 |
| N-Desmethylclobazam solution 100?μg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant? | D-049 | 1mL | $264 |
| N-Desmethylclobazam ≥98% | 18564 | 1mg | $81 |
| N-Desmethylclobazam ≥98% | 18564 | 5mg | $355 |
| N-Desmethylclobazam (CRM) | 18888 | 100μg | $119 |
| Melting point | >239°C (dec.) |
|---|---|
| Boiling point | 601.8±55.0 °C(Predicted) |
| Density | 1.363±0.06 g/cm3(Predicted) |
| Flash point | 2℃ |
| storage temp. | Controlled Substance, -20°C Freezer |
| solubility | Acetonitrile (Soluble) |
| pka | 7.57±0.20(Predicted) |
| form | A neat solid |
| Major Application | clinical testing |
| InChI | 1S/C15H11ClN2O2/c16-10-6-7-12-13(8-10)18(11-4-2-1-3-5-11)15(20)9-14(19)17-12/h1-8H,9H2,(H,17,19) |
| InChIKey | RRTVVRIFVKKTJK-UHFFFAOYSA-N |
| SMILES | O=C(C1)N(C2=CC=CC=C2)C3=C(C=CC(Cl)=C3)NC1=O |
| EWG's Food Scores | 1 |
| FDA UNII | MZ4L647O2H |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H225-H302+H312+H332-H319 |
| Precautionary statements | P210-P280-P301+P312-P303+P361+P353-P304+P340+P312-P305+P351+P338 |
| Hazard Codes | F,Xn |
| Risk Statements | 11-20/21/22-36 |
| Safety Statements | 16-36/37 |
| RIDADR | UN 1648 3 / PGII |
| WGK Germany | 2 |
| Storage Class | 3 - Flammable liquids |
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Flam. Liq. 2 |
| Toxicity | mouse,LD50,oral,> 2583mg/kg (2583mg/kg),United States Patent Document. Vol. #3760074, |
8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D-145 | N-Desmethylclobazam solution 1.0?mg/mL (acetonitrile:DMSO (90:10 v/v)), ampule of 1?mL, certified reference material, Cerilliant? | 22316-55-8 | 1ML | $435 | 2025-07-31 | Buy |
| Sigma-Aldrich | D-049 | N-Desmethylclobazam solution 100?μg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant? | 22316-55-8 | 1mL | $264 | 2025-07-31 | Buy |
| Cayman Chemical | 18564 | N-Desmethylclobazam ≥98% | 22316-55-8 | 1mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 18564 | N-Desmethylclobazam ≥98% | 22316-55-8 | 5mg | $355 | 2024-03-01 | Buy |
| Cayman Chemical | 18888 | N-Desmethylclobazam (CRM) | 22316-55-8 | 100μg | $119 | 2024-03-01 | Buy |
8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione Chemical Properties,Uses,Production
Description
N-Desmethylclobazam (Item No. 18564) is an analytical reference material that is structurally categorized as a benzodiazepine. It is a major active metabolite of clobazam, produced primarily by the action of cytochrome P450 isoform 3A4. N-Desmethylclobazam positively modulates GABAA receptors (EC50s range from 98 to 151 μM, depending on subunit configuration). This product is intended for research and forensic applications.
Description
N-Desmethylclobazam (CRM) (Item No. 18888) is a certified reference material that is structurally categorized as a benzodiazepine. It is a major active metabolite of clobazam, produced primarily by the action of cytochrome P450 isoform 3A4. N-Desmethylclobazam (CRM) positively modulates GABAA receptors (EC50s range from 98 to 151 μM, depending on subunit configuration). This product is intended for research and forensic applications.
Chemical Properties
Off-White Solid
Uses
The major metabolite of Clobazam Controlled substance (depressant).
Definition
ChEBI: N-Desmethylclobazam is a benzodiazepine.
General Description
A Certified Solution Standard for use in LC or GC applications from forensic and forensic toxicology analysis to urine drug testing. N-Desmethylclobazam, found in urine, serum, and plasma, is the pharmacologically active, major metabolite of clobazam.
References
[1] JOSE DE LEON Francisco J D Edoardo Spina. Clobazam therapeutic drug monitoring: a comprehensive review of the literature with proposals to improve future studies.[J]. Therapeutic Drug Monitoring, 2013, 35 1: 30-47. DOI: 10.1097/ftd.0b013e31827ada88
[2] HARRIET HAMMER. Functional characterization of the 1,5-benzodiazepine clobazam and its major active metabolite N-desmethylclobazam at human GABA(A) receptors expressed in Xenopus laevis oocytes.[J]. PLoS ONE, 2015: e0120239. DOI: 10.1371/journal.pone.0120239
8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione Preparation Products And Raw materials
8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12373 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 8401 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19183 | 58 |
| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 | ellena@amitychem.com | China | 43416 | 58 |
| QUALITY CONTROL SOLUTIONS LTD. | +86-0755-66853366 +86-13670046396 | export03@qcsrm.com | China | 24342 | 58 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 | shenlinxing@macklin.cn | China | 15872 | 55 |
| Jinan Kaypharm Chemical Co.,Ltd. | 0531-86986780 13153183025 | sales@kaypharm.cn | China | 103 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
