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4-Chloro-2-fluoronitrobenzene

4-Chloro-2-fluoronitrobenzene Structure
4-Chloro-2-fluoronitrobenzene structure
CAS No.
700-37-8
Chemical Name:
4-Chloro-2-fluoronitrobenzene
Synonyms
4-CHLORO-2-FLUORO-1-NITROBENZENE;Chlorofluoronitrobenzene;2-fluoro-4-chloroitrobenzene;2-FLUORO-4-CHLORONITROBENZENE;4-CHLORO-2-FLUORONITROBENZENE;4-Chloro-5-fluoronitrobenzene;4-Chlor-2-fluor-1-nitrobenzol;4-Chloro-2-fluoronitrobenzenen;4-Choro-2-fluoro-1-nitrobenzene;1-CHLORO-3-FLUORO-4-NITROBENZENE
CBNumber:
CB2478991
Molecular Formula:
C6H3ClFNO2
Molecular Weight:
175.54
MDL Number:
MFCD00042211
MOL File:
700-37-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-31 16:43:09
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4-Chloro-2-fluoronitrobenzene Properties

Melting point 48°C
Boiling point 241.8±20.0 °C(Predicted)
Density 1.494±0.06 g/cm3(Predicted)
Flash point >110℃
storage temp. Sealed in dry,Room Temperature
form powder to crystal
color White to Light yellow to Green
InChI InChI=1S/C6H3ClFNO2/c7-4-1-2-6(9(10)11)5(8)3-4/h1-3H
InChIKey PTCPUGKKWNMITF-UHFFFAOYSA-N
SMILES C1([N+]([O-])=O)=CC=C(Cl)C=C1F
CAS DataBase Reference 700-37-8(CAS DataBase Reference)
UNSPSC Code 12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi,Xn
Risk Statements  20/21/22-36/37/38-22
Safety Statements  26-36/37/39-37
WGK Germany  WGK 3
HazardClass  IRRITANT
HS Code  29042090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral

4-Chloro-2-fluoronitrobenzene price More Price(53)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical C1261 4-Chloro-2-fluoronitrobenzene >96.0%(GC) 700-37-8 5g $22 2026-04-30 Buy
TCI Chemical C1261 4-Chloro-2-fluoronitrobenzene >96.0%(GC) 700-37-8 25g $65 2026-04-30 Buy
Apolloscientific PC1875 4-Chloro-2-fluoronitrobenzene 98% 700-37-8 5g $21 2026-06-04 Buy
Apolloscientific PC1875 4-Chloro-2-fluoronitrobenzene 98% 700-37-8 25g $44 2026-06-04 Buy
Apolloscientific PC1875 4-Chloro-2-fluoronitrobenzene 98% 700-37-8 100g $154 2026-06-04 Buy
Product number Packaging Price Buy
C1261 5g $22 Buy
C1261 25g $65 Buy
PC1875 5g $21 Buy
PC1875 25g $44 Buy
PC1875 100g $154 Buy

4-Chloro-2-fluoronitrobenzene Chemical Properties, Uses, Production

Description

4-chloro-2-fluoronitrobenzene is a vital farming intermediate approximately, such as synthetic low toxicity, broad spectrum, ultra-high efficiency weedicide fluthiacetmethyl. The existing synthetic method has a great majority of 2, and 4-dichloronitrobenzene is a starting raw material, so prepare 4-chloro-2-fluoronitrobenzene through the halogen replacement(metathesis)reaction.

Chemical Properties

Pale yellow solid

Uses

4-Chloro-2-fluoronitrobenzene serves as a precursor for synthesizing 5-(1H-imidazol-1-yl)-N-methyl-2-nitroaniline via sequential reaction with aqueous methylamine and imidazole[3].

Synthesis

2,4-Dichloronitrobenzene

611-06-3

2,4-Difluoronitrobenzene

446-35-5

4-Chloro-2-fluoronitrobenzene

700-37-8

General procedure: Potassium fluoride (KF), 2,4-dichloronitrobenzene (DCNB) and solvent are added to a Schott tube or reactor, which is subjected to a nitrogen atmosphere. Subsequently, the reaction mixture is heated at the specified temperature for 4 hours. Upon completion of the reaction, the reaction mixture is filtered and analyzed by gas chromatography. Example 1: In this example, the following reaction conditions were used: a molar ratio of 2,4-dichloronitrobenzene (DCNB) to potassium fluoride (KF) of 1:2 (the actual amount used was 1.05 times the theoretical amount), and tetramethylammonium chloride (TMAC) in an amount of 0.04 times the molar amount of DCNB. The reaction was carried out at 170 °C for 4 h, using a Schott tube as the reaction vessel. Numbers in parentheses indicate the molar ratio relative to the substrate (DCNB).

References

[1] Patent: US2004/24238,  2004,  A1. Location in patent: Page 5
[2] Patent: US2004/24238,  2004,  A1. Location in patent: Page 6
[3] Ohmori, J., Shimizu-Sasamata, M., Okada, M., Sakamoto, S. (1996). Novel AMPA Receptor Antagonists:  Synthesis and Structure−Activity Relationships of 1-Hydroxy-7-(1H-imidazol-1-yl)-6-nitro-2,3(1H,4H)- quinoxalinedione and Related Compounds. Journal of Medicinal Chemistry, 39(20), 3971–3979. https://doi.org/10.1021/jm960387+

4-Chloro-2-fluoronitrobenzene Preparation Products And Raw materials

Raw materials

2,4-Dichloronitrobenzene Sulfolane Potassium fluoride

Preparation Products

4-Chloro-2-fluoroaniline 2-Chloro-4-fluoronitrobenzene 2,4-Difluoronitrobenzene 8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione 5-Chloro-2-nitrodiphenylamine
ethyl 1-(5-chloro-2-nitrophenyl)-4-piperidinecarboxylate methyl 2-(4-chloro-2-nitrophenoxy)benzoate 4-Chloro-2-(methylthio)nitrobenzene, 4-Chloro-2-(methylsulphanyl)nitrobenzene, 4-Chloro-2-(methylmercapto)nitrobenzene

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4-Chloro-2-fluoronitrobenzene Suppliers

Global Suppliers ( 266)
Supplier Tel Email Country ProdList Advantage
Tongchuang Pharma(Suzhou). Co., Ltd. 0512-63263366 18912765016 tongtf110@sina.com China 984 62
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Supplier Advantage
Tongchuang Pharma(Suzhou). Co., Ltd. 62
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
Beijing Ouhe Technology Co., Ltd 60
JinYan Chemicals(ShangHai) Co.,Ltd. 60

View Latest Price from 4-Chloro-2-fluoronitrobenzene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Chloro-2-fluoronitrobenzene pictures 2026-03-20 4-Chloro-2-fluoronitrobenzene
700-37-8
 1KG 99% 20 mt Hebei Chuanghai Biotechnology Co., Ltd
4-Chloro-2-fluoronitrobenzene pictures 2023-11-03 4-Chloro-2-fluoronitrobenzene
700-37-8
 $10.00 1kg 99% 100T Anhui Zhongda Biotechnology Co., Ltd
4-Chloro-2-fluoronitrobenzene pictures 2019-07-06 4-Chloro-2-fluoronitrobenzene
700-37-8
 $1.00 1KG 98% 150KG Career Henan Chemical Co

4-Chloro-2-fluoronitrobenzene Spectrum

4-Chloro-2-fluoronitrobenzene(700-37-8)MS4-Chloro-2-fluoronitrobenzene(700-37-8)1HNMR4-Chloro-2-fluoronitrobenzene(700-37-8)13CNMR4-Chloro-2-fluoronitrobenzene(700-37-8)IR14-Chloro-2-fluoronitrobenzene(700-37-8)IR2

700-37-8 (4-Chloro-2-fluoronitrobenzene) Related Search:

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4-CHLORO-2-FLUORONITROBENZENE 2-FLUORO-4-CHLORONITROBENZENE 1-CHLORO-3-FLUORO-4-NITROBENZENE Chlorofluoronitrobenzene 4-Chlor-2-fluor-1-nitrobenzol 4-Chloro-2-fluoronitrobenzenen 2-fluoro-4-chloroitrobenzene 4-Chloro-5-fluoronitrobenzene 4-CHLORO-2-FLUORONITROBENZENE 95+% 1-Nitro-2-fluoro-4-chlorobenzene Sodium salt 6-hydroxy-4-pyrimidinecarboxylate 4-Chloro-2-fluoronitrobenzene, 97+% Benzene, 4-chloro-2-fluoro-1-nitro- 4-Chloro-2-fluoronitrobenzene > 4-Chloro-2-fluoronitrobenzene ISO 9001：2015 REACH 700-37-8 4-Chloro-2-fluoronitrobenzene C6H3ClFNO2 4-Choro-2-fluoro-1-nitrobenzene 4-CHLORO-2-FLUORO-1-NITROBENZENE 700-37-8 Fluorine series