MONOMETHYL MALONATE
- CAS No.
- 16695-14-0
- Chemical Name:
- MONOMETHYL MALONATE
- Synonyms
- 3-methoxy-3-oxopropanoic acid;Methyl hydrogen malonate;3-methoxy-3-oxopropanoate;AURORA KA-6464;1-Methyl malonate;monmethyl malonate;MONOMETHYL MALONATE;3-Methoxy-3-oxopropanoicaci;(Methoxycarbonyl)acetic acid;Methyl hydrogen malonate, 96%
- CBNumber:
- CB9416569
- Molecular Formula:
- C4H6O4
- Molecular Weight:
- 118.09
- MDL Number:
- MFCD00667796
- MOL File:
- 16695-14-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-Methoxy-3-oxopropanoic Acid | M3615 | 1G | $89 |
| Propanedioic acid 1-methyl ester | FP32631 | 0.5kg | $649 |
| Propanedioic acid 1-methyl ester | FP32631 | 1kg | $1038.4 |
| Monomethyl malonate 98% | OR54514 | 1g | $21 |
| Monomethyl malonate 98% | OR54514 | 5g | $24 |
| More product size | |||
| Boiling point | 232℃ |
|---|---|
| Density | 1.128 |
| refractive index | 1.428 |
| Flash point | 104℃ |
| storage temp. | Sealed in dry,Room Temperature |
| form | solid |
| pka | 2.83±0.32(Predicted) |
| Appearance | Colorless to light yellow Liquid |
| InChI | 1S/C4H6O4/c1-8-4(7)2-3(5)6/h2H2,1H3,(H,5,6) |
| InChIKey | PBVZQAXFSQKDKK-UHFFFAOYSA-N |
| SMILES | COC(=O)CC(O)=O |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HS Code | 29161900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
MONOMETHYL MALONATE price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M3615 | 3-Methoxy-3-oxopropanoic Acid | 16695-14-0 | 1G | $89 | 2026-04-30 | Buy |
| Biosynth | FP32631 | Propanedioic acid 1-methyl ester | 16695-14-0 | 0.5kg | $649 | 2026-06-04 | Buy |
| Biosynth | FP32631 | Propanedioic acid 1-methyl ester | 16695-14-0 | 1kg | $1038.4 | 2026-06-04 | Buy |
| Apolloscientific | OR54514 | Monomethyl malonate 98% | 16695-14-0 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR54514 | Monomethyl malonate 98% | 16695-14-0 | 5g | $24 | 2026-06-04 | Buy |
MONOMETHYL MALONATE Chemical Properties,Uses,Production
Chemical Properties
Clear Liquid
Uses
Lactonization of olefins with monomethyl ester of malonic acid and ceric ammonium nitrate was carried out in acetic acid and in acetonitrile under simple mechanical stirring or ultrasound irradiation. Lactonization of olefins with CAN and monomethyl ester of malonic acid under ultrasound irradiation shows an acceleration with respect to the analogous mechanically stirred reaction.
Definition
ChEBI: 3-Methoxy-3-oxopropanoic acid is a dicarboxylic acid.
Synthesis
108-59-8
16695-14-0
The general procedure for the synthesis of monomethyl malonate from dimethyl malonate is as follows: 1. In a 1 L single neck flask equipped with a magnetic stirrer, 158.33 g (1.2 mol) of dimethyl malonate was added and 10 μL of acetonitrile was added to dissolve the dimethyl malonate. 2. The solution was stirred for 1 minute and then the reaction mixture was cooled to 0°C using an ice water bath. 3. 100 mL of water was added to the mixture and stirring was continued for 30 minutes. 4. 240 mL of a 5M KOH aqueous solution (1.2 mol) was added dropwise while using a dispensing funnel to complete the dropwise addition in 15 minutes (20 mL of 0.5 M oxalic acid was used to titrate the 5M KOH solution; oxalic acid was purchased from Mallinckrodt Company, Hazelwood, MO). 5. After the titration was complete, the reaction mixture continued to be stirred for 60 minutes, during which time the flask was covered with a stopper and kept in an ice water bath. 6. Upon completion of the reaction, the reaction mixture was acidified with 150 mL of aqueous 12M HCl in an ice water bath and subsequently saturated with NaCl. 7. Using a 1L dispensing funnel, the acidified mixture was extracted with five 500mL portions of ethyl acetate. 8. The ethyl acetate extracts were combined and washed with 500mL of saturated aqueous NaCl. 9. The ethyl acetate extract was dried with about 100 g of anhydrous sodium sulfate. 10. After removing the desiccant by gravity filtration, the ethyl acetate solution was concentrated using a rotary evaporator. 11. Distillation was carried out at 2.5 mmHg under reduced pressure and the fraction with a boiling point of 91-92 °C was collected to give monomethyl malonate as a colorless oil. 12. The product was recovered at 45 °C in a yield of 114.77 g (81%) containing 4% dimethyl malonate and 1% malonic acid. Note: Examples 26-36 were prepared using the same procedure as Example 37, but the reaction conditions were adjusted according to Table 4 below.
References
[1] Tetrahedron Letters, 2008, vol. 49, # 28, p. 4434 - 4436
[2] Chemical and Pharmaceutical Bulletin, 2009, vol. 57, # 5, p. 508 - 510
[3] Patent: WO2008/150487, 2008, A2. Location in patent: Page/Page column 14-17
[4] Patent: WO2008/150487, 2008, A2. Location in patent: Page/Page column 16-17
MONOMETHYL MALONATE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2165 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
View Lastest Price from MONOMETHYL MALONATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-03-20 | MONOMETHYL MALONATE
16695-14-0
|
$1.00 | 1kg | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
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2025-04-04 | MONOMETHYL MALONATE
16695-14-0
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
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2020-01-13 | MONOMETHYL MALONATE
16695-14-0
|
$1.00 | 1KG | 98% | 10 tons | Career Henan Chemical Co |
-
- MONOMETHYL MALONATE
16695-14-0
- $1.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- MONOMETHYL MALONATE
16695-14-0
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- MONOMETHYL MALONATE
16695-14-0
- $1.00
- 98%
- Career Henan Chemical Co
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