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2,4-Dichloro-5-methylpyrimidine

2,4-Dichloro-5-methylpyrimidine Structure
2,4-Dichloro-5-methylpyrimidine structure
CAS No.
1780-31-0
Chemical Name:
2,4-Dichloro-5-methylpyrimidine
Synonyms
4-Dichloro-5-MethylpyriMidine;NSC 37532;Toxic,stench;2,4-Dichloro-5-;2,4-Dichloro-5-methy;Dichloro-5-MethylpyriMid;2,4-Dichloro-5-Methylpyri...;5-Methyl-2,4-dichloropyrimidine;2,4-DICHLORO-5-METHYLPYRIMIDINE;2,4-dichloro-5-methyl-pyrimidin
CBNumber:
CB6130202
Molecular Formula:
C5H4Cl2N2
Molecular Weight:
163
MDL Number:
MFCD00023197
MOL File:
1780-31-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-04 16:00:12
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2,4-Dichloro-5-methylpyrimidine Properties

Melting point 26-28 °C (lit.)
Boiling point 108-109 °C/11 mmHg (lit.)
Density 1.39 g/mL at 25 °C (lit.)
refractive index 1.6300 (estimate)
Flash point >230 °F
storage temp. Inert atmosphere,2-8°C
solubility Soluble in chloroform, ether, ethyl acetate and toluene
form powder to lump to clear liquid
pka -2.44±0.29(Predicted)
color White or Colorless to Almost white or Almost colorless
Sensitive Lachrymatory
InChI InChI=1S/C5H4Cl2N2/c1-3-2-8-5(7)9-4(3)6/h2H,1H3
InChIKey DQXNTSXKIUZJJS-UHFFFAOYSA-N
SMILES C1(Cl)=NC=C(C)C(Cl)=N1
CAS DataBase Reference 1780-31-0(CAS DataBase Reference)
FDA UNII G2W3V2TE7S
EPA Substance Registry System Pyrimidine, 2,4-dichloro-5-methyl- (1780-31-0)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363
PPE Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Hazard Codes  C
Risk Statements  34
Safety Statements  26-36/37/39-45-27
RIDADR  UN 3261 8/PG 2
WGK Germany  3
TSCA  TSCA listed
HazardClass  8
PackingGroup  III
HS Code  29335990
Storage Class 8A - Combustible corrosive hazardous materials
Hazard Classifications Skin Corr. 1B
Limited Quantities 1 Kg (2.2 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
NFPA 704
1
3 0

2,4-Dichloro-5-methylpyrimidine price More Price(75)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D66182 2,4-Dichloro-5-methylpyrimidine 98% 1780-31-0 5g $120 2026-04-30 Buy
Sigma-Aldrich D66182 2,4-Dichloro-5-methylpyrimidine 98% 1780-31-0 1g $34.4 2023-06-20 Buy
TCI Chemical D3613 2,4-Dichloro-5-methylpyrimidine >98.0%(GC) 1780-31-0 1g $20 2026-04-30 Buy
TCI Chemical D3613 2,4-Dichloro-5-methylpyrimidine >98.0%(GC) 1780-31-0 5g $38 2026-04-30 Buy
Usbiological D3531-30 2,4-Dichloro-5-methylpyrimidine|**Toxic, Stench** 5g $425 2026-06-03 Buy
Product number Packaging Price Buy
D66182 5g $120 Buy
D66182 1g $34.4 Buy
D3613 1g $20 Buy
D3613 5g $38 Buy
D3531-30 5g $425 Buy

2,4-Dichloro-5-methylpyrimidine Chemical Properties, Uses, Production

Chemical Properties

White to Off White Low Melting Solid

Uses

2,4-Dichloro-5-methylpyrimidine, is used in the synthesis of (2-chloro-6-methyl-pyrimidin-4-yl)-(2,3-dihydro-benzothiazol-6-yl)-amine. It can react with piperidineto produce 2-chloro-5-methyl-4-piperidin-1-yl-pyrimidine. This reaction will need solvent dioxane.

Synthesis

Thymine

65-71-4

2,4-Dichloro-5-methylpyrimidine

1780-31-0

General procedure for the synthesis of 2,4-dichloro-5-methylpyrimidine from 5-methyluracil: 5-methyluracil (1 g, 7.93 mmol) was added to phosphorochloridic acid (7 eq., 5 ml), and the mixture was heated and refluxed for 3 hours. After completion of the reaction, the mixture was slowly poured into ice water to quench the reaction. The organic layer was extracted with chloroform (3 x 20 ml), the organic phases were combined and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give 2,4-dichloro-5-methylpyrimidine as yellow crystals (0.62 g, 48% yield). The structure of the product was confirmed by nuclear magnetic resonance hydrogen (1H NMR, 400 MHz, CDCl3) and carbon (13C NMR, 100 MHz, CDCl3) spectra: 1H NMR δ 8.35 (s, 1H), 2.39 (s, 3H); 13C NMR δ 162.5, 160.0, 158.2, 129.1, 15.8. The data obtained were in agreement with those of literature reports (Wang et al., Molecules, 2012, 17(4), 4533-4544).

References

[1] Journal of Fluorine Chemistry, 1996, vol. 77, # 1, p. 93 - 95
[2] Patent: WO2018/151681, 2018, A1. Location in patent: Paragraph 0099
[3] Synthetic Communications, 1992, vol. 22, # 20, p. 2927 - 2934
[4] Tetrahedron Letters, 1997, vol. 38, # 7, p. 1111 - 1114
[5] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 18, p. 2961 - 2966

2,4-Dichloro-5-methylpyrimidine Preparation Products And Raw materials

Raw materials

Thymine

Preparation Products

2-Pyrimidinamine, 4-chloro-5-methyl- (9CI) Pyrimidine, 2-chloro-4,5-dimethyl- (9CI) 4-Pyrimidinamine, 2-chloro-5-methyl-N-[(1S)-1-(3-pyridinyl)butyl]- Pyrimidine, 2,4-difluoro-5-methyl- (9CI) 2-chloro-5-MethylpyriMidin-4-ol
2-Chloro-4-benzylamino-5-methylpyrimidine 2-chloro-N,5-dimethyl-pyrimidin-4-amine 2-hydrazino-5-methyl-4-(2-thienyl)pyrimidine 5-(2-chloro-5-MethylpyriMidin-4-ylaMino)benzo[d]oxazol-2(3H)-one

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2,4-Dichloro-5-methylpyrimidine Suppliers

Global Suppliers ( 432)
Supplier Tel Email Country ProdList Advantage
Dongyang Qiusuo Medical Technology Co., LTD 17502510579 2785299132@qq.com China 1557 58
Suzhou Tianhong Medicine Chemical Technology Co.,Ltd. 18949937116 dongye.huaxue@126.com China 143 58
China Shenyang Tyschem CO. ,LTD +86-024-83607930 18640359690 sales@honghuchem.com China 256 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Supplier Advantage
Dongyang Qiusuo Medical Technology Co., LTD 58
Suzhou Tianhong Medicine Chemical Technology Co.,Ltd. 58
China Shenyang Tyschem CO. ,LTD 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
ShangHai DEMO Chemical Co.,Ltd 57

View Latest Price from 2,4-Dichloro-5-methylpyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,4-Dichloro-5-methylpyrimidine pictures 2026-09-02 2,4-Dichloro-5-methylpyrimidine
1780-31-0
 $5.00 1KG 98% Henan Fengda Chemical Co., Ltd
2,4-Dichloro-5-methylpyrimidine pictures 2026-08-20 2,4-Dichloro-5-methylpyrimidine
1780-31-0
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
2,4-Dichloro-5-methylpyrimidine pictures 2026-06-30 2,4-Dichloro-5-methylpyrimidine
1780-31-0
 1KG 99.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd

2,4-Dichloro-5-methylpyrimidine Spectrum

2,4-Dichloro-5-methylpyrimidine(1780-31-0)1HNMR2,4-Dichloro-5-methylpyrimidine(1780-31-0)IR

1780-31-0 (2,4-Dichloro-5-methylpyrimidine) Related Search:

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2,4-dichloro-5-methyl-pyrimidin 2,4-Dichloro-5-methyl-1,3-diazine Dichloro-5-MethylpyriMid 2,4-DICHLORO-5-METHYLPYRIMIDINE 2,4-Dichloro-5-methylpyrimidine **Toxic, Stench** Toxic,stench PYRIMIDINE,2,4-DICHLORO-5-METHYL 2,4-Dichloro-5- 5-Methyl-2,4-dichloropyrimidine NSC 37532 2,4-Dichloro-5-methylpyrimidine ,98% 2,4-Dichloro-5-methylpyrimidine ,97% 2,4-Dichloro-5-methy 2,4-Dichloro-5-Methylpyri... 2,4-Dichloro-5-methylpyrimidine> 2,4-Dichloro-5-methylpyrimidine ISO 9001：2015 REACH (S)-1-(pyridin-3-yl)butan-1-amine 4-Dichloro-5-MethylpyriMidine 1780-31-0 21780-31-0 178-31-0 C5H4Cl2N2Cl Building Blocks Heterocyclic Building Blocks Pyrimidines Halogenated Heterocycles Heterocycle-Pyrimidine series C4 to C5 Chemical Synthesis Halogenated Heterocycles Heterocyclic Building Blocks pharmacetical Nucleic acids Bases & Related Reagents Nucleotides Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks PyrimidinesHeterocyclic Building Blocks Halides Heterocycles Pyrimidine Building Blocks Halogenated Nucleotides and Nucleosides Pyrimidines